Analysis of circular RNA expression profiles of lung cancer in Xuanwei, China

Wang, Yan; Lu, Lingjiao; Duan, Yong; Liu, Xiao; Mao, Yuan; Chen, Yu; Zhang, Yanliang

doi:10.1002/jcla.23521

Cited by 6 publications

(5 citation statements)

References 35 publications

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“…Ryo Uratani et al demonstrated the potential role of total serum miR-21, miR-29a and miR-92a in the early detection of colorectal adenomas and cancers [62]. CircRNAs and exosomal circRNAs have the potential diagnostic values for Gastrointestinal (GI) malignancies and lung cancer [63,64]. Nevertheless, the role of exosomal clinical correlation of plasma exosomal circRNAs in colorectal adenomas compared to the healthy control group based on the results of the RNA sequence.…”

Section: Discussionmentioning

confidence: 99%

Exosomal circRNAs as novel potential biomarkers for colorectal adenoma

Cheng

Liu

2022

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Growing evidences have revealed that exosomal miRNAs, lncRNAs, and circRNAs play a pleiotropic role in tumor biology. Cell-cell communication mediated by exosomes has been considered to be a key factor in the malignant pro gression of colorectal cancer. However, the importance of exosome-derived circRNAs in the biological function and clinical significance of colorectal adenoma remains elusive. In this study, we aimed to identify altered circRNA expression profiles in exosomes isolated from plasma of patients with colorectal adenoma using high-throughput sequencing. Exosomes were confirmed by western blotting, transmission electron microscopy, and nanosight assay. The sequencing data indicated that there are 413 differentially expressed circRNAs including 112 upregulated and 301 downregulated circRNAs in colorectal adenoma patients compared with controls. GO analysis and the circRNA-miRNA-mRNA network were performed to predict the potential function of circRNAs, and demonstrate the putative mechanisms in colorectal adenoma. Collectively, our findings revealed that plasma exosomal circRNAs may be a potential noninvasive biomarker for the detection of colorectal adenoma, and provided new insights into colorectal adenoma-carcinoma sequence.

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Section: Discussionmentioning

confidence: 99%

Exosomal circRNAs as novel potential biomarkers for colorectal adenoma

Cheng

Liu

2022

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“…For instance, the circVDAC3 is overexpressed in colorectal cancer (CRC) tissues and inhibits tumour progression via the miR‐942‐5p/BATF2 axis 7 . Furthermore, circVDAC3 is also overexpressed in the plasma of CRC patients, and high levels have been detected in the tumour tissues of lung cancer patients in Xuanwei 8,9 …”

Section: Introductionmentioning

confidence: 99%

“… 7 Furthermore, circVDAC3 is also overexpressed in the plasma of CRC patients, and high levels have been detected in the tumour tissues of lung cancer patients in Xuanwei. 8 , 9 …”

Section: Introductionmentioning

confidence: 99%

CircRNA LOC729852 promotes bladder cancer progression by regulating macrophage polarization and recruitment via the miR‐769‐5p/IL‐10 axis

Dong,

Hui,

et al. 2024

J Cellular Molecular Medi

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Circular RNAs (circRNAs) function as tumour promoters or suppressors in bladder cancer (BLCA) by regulating genes involved in macrophage recruitment and polarization. However, the underlying mechanisms are largely unknown. The aim of this study was to determine the biological role of circLOC729852 in BLCA. CircLOC729852 was upregulated in BLCA tissues and correlated with increased proliferation, migration and epithelial mesenchymal transition (EMT) of BCLA cells. MiR‐769‐5p was identified as a target for circLOC729852, which can upregulate IL‐10 expression by directly binding to and suppressing miR‐769‐5p. Furthermore, our results indicated that the circLOC729852/miR‐769‐5p/IL‐10 axis modulates autophagy signalling in BLCA cells and promotes the recruitment and M2 polarization of TAMs by activating the JAK2/STAT3 signalling pathway. In addition, circLOC729852 also promoted the growth of BLCA xenografts and M2 macrophage infiltration in vivo. Thus, circLOC729852 functions as an oncogene in BLCA by inducing secretion of IL‐10 by the M2 TAMs, which then facilitates tumour cell growth and migration. Taken together, circLOC729852 is a potential diagnostic biomarker and therapeutic target for BLCA.

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“…LUAD is the main pathological type of XWLC. In recent years, the molecular mechanisms underlying the Xuanwei LUAD have been widely reported by high throughput techniques [11][12][13]. These studies described differentially expressed molecules and pathway changes in tumor tissues and provided high potential research value for XWLC.…”

Section: Introductionmentioning

confidence: 99%

Integrated multi-omics analysis for lung adenocarcinoma in Xuanwei, China

Jiang,

Yang,

et al. 2023

Aging

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Background: Xuanwei lung cancer (XWLC) is well-known for its high incidence and mortality. However, the molecular mechanism is still unclear. Methods: We performed a comprehensive transcriptomic, proteomic, and phosphoproteomic characterization of tumors and matched normal adjacent tissues from three XWLC patients with lung adenocarcinoma (LUAD). Results: Integrated transcriptome and proteome analysis revealed dysregulated molecules and pathways in tumors and identified enhanced metabolic-disease coupling. Non-coding RNAs were widely involved in posttranscriptional regulatory mechanisms to coordinate the progress of LUAD and partially explained the molecular differences between RNA and protein expression patterns. Phosphoproteome provided evidence support for new phosphate sites, reporting the potential roles of core kinase family members and key kinase pathways involved in metabolism, immunity, and homeostasis. In addition, by comparing with the previous LUAD researches, we emphasized the higher degree of oxidative phosphorylation in Xuanwei LUAD and pointed that VIPR1 deficiency aggravated metabolic dysfunction. Conclusion: Our integrated multi-omics analysis provided a powerful resource for a systematic understanding of the molecular structure of XWLC and proposed therapeutic opportunities based on redox metabolism.

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Analysis of circular RNA expression profiles of lung cancer in Xuanwei, China

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 6 publications

References 35 publications

Exosomal circRNAs as novel potential biomarkers for colorectal adenoma

Exosomal circRNAs as novel potential biomarkers for colorectal adenoma

CircRNA LOC729852 promotes bladder cancer progression by regulating macrophage polarization and recruitment via the miR‐769‐5p/IL‐10 axis

Integrated multi-omics analysis for lung adenocarcinoma in Xuanwei, China

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