Analysis of Collagen-Binding Integrin Interactions with Supramolecular Aggregates of the Extracellular Matrix

Hansen, Uwe

doi:10.1007/978-1-4939-9095-5_12

Cited by 1 publication

(1 citation statement)

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“…The interactions between chondrocytes and the ECM mediated by integrins are crucial for chondrocyte activity. ECM, as an "informative" environment, is made up of many molecules, including COLII, proteoglycans (PGs), hyaluronic acid (HA), and chondroitin sulfate (CS), etc., And the various components in the ECM are important for the structure and function of the ECM (Gao et al, 2014;Hansen, 2019). ECM changes in OA seem to be driven by the imbalance between anabolic and catabolic activities of chondrocytes, which are responsible for the occurrence and development of OA.…”

Section: Integrins In Chondrocytes Adhesionmentioning

confidence: 99%

Mechanistic Insight Into the Roles of Integrins in Osteoarthritis

Jin

Jiang²,

Wang³

et al. 2021

Front. Cell Dev. Biol.

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Osteoarthritis (OA), one of the most common degenerative diseases, is characterized by progressive degeneration of the articular cartilage and subchondral bone, as well as the synovium. Integrins, comprising a family of heterodimeric transmembrane proteins containing α subunit and β subunit, play essential roles in various physiological functions of cells, such as cell attachment, movement, growth, differentiation, and mechanical signal conduction. Previous studies have shown that integrin dysfunction is involved in OA pathogenesis. This review article focuses on the roles of integrins in OA, especially in OA cartilage, subchondral bone and the synovium. A clear understanding of these roles may influence the future development of treatments for OA.

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Section: Integrins In Chondrocytes Adhesionmentioning

confidence: 99%