Analysis of Complexation Interactions between Metal Ions and Drugs under Pseudo-physiological pH Conditions by a High-throughput Screening Method Using a Solid-phase Extraction Cartridge

Moriiwa, Yukiko; Suzuki, Naoki; Shoji, Atsushi; Yanagida, Akio

doi:10.2116/analsci.19p413

Cited by 7 publications

(1 citation statement)

References 34 publications

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“…Metal chelation is also a promising strategy for the development of new compounds to treat antibiotic-resistant infections. It has the potential to create novel compounds with increased efficacy and reduced side effects [ 5 , 6 , 7 , 8 ]. However, further research is needed to fully understand the mechanisms of metal chelation and to optimize the design of chelators for maximum efficacy.…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Physical and Chemical Properties of Differently Obtained Zn—Methionine Chelate with Proved Antibiofilm Properties (Part II)

et al. 2023

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The previously demonstrated activity of aqueous solutions of methionine and zinc salts against biofilms of uropathogenic bacteria prompted us to investigate the structure and properties of zinc methionine complex obtained from such solutions. The paper presents the analysis results of zinc coordination complexes with methionine obtained by synthesis (0.034 mol of L-methionine, 0.034 mol of NaOH, 40 mL of H2O, 0.017 mol ZnSO4, 60 °C) and simple crystallization from water solution (25 mL of a solution containing 134 mmol/L L-methionine, 67 mmol/L ZnSO4, pH = 5.74, I = 0.37 mmol/L, crystallization at room temperature during more than two weeks). IR spectral analysis and X-ray diffraction showed the structural similarity of the substances to each other, in agreement with the data described in the literature. DSC confirmed the formation of a thermally stable (in the range from −30 °C to 180 °C) chelate compound in both cases and indicated the possible retention of the polymorphic two-dimensional structure inherent in L-methionine with the temperature of phase transition 320 K. The crystallized complex had better solubility in water (100 to 1000 mL per 1.0 g) contra the synthesized analog, which was practically insoluble (more than 10 000 mL per 1.0 g). The results of the solubility assessment, supplemented by the results of the dispersion analysis of solutions by the dynamic light scattering method indicated the formation of zinc-containing nanoparticles (80 nm) in a saturated water solution of a crystallized substance, suggesting the crystallized substance may have higher bioavailability. We predicted a possibility of the equivalent existence of optically active cis and trans isomers in methionine-zinc solutions by the close values of formation enthalpy (−655 kJ/mol and −657 kJ/mol for cis and trans forms, respectively) and also illustrated by the polarimetry measurement results (∆α = 0.4°, pH = 5.74, C(Met) = 134 mmol/L; the concentration of metal ion gradually increased from 0 to 134 mmol/L). The obtained results allowed us to conclude that the compound isolated from the solution is a zinc-methionine chelate with the presence of sulfate groups and underline the role of the synthesis route for the biopharmaceutical characteristics of the resulting substance. We provided some quality indicators that it may be possible to include in the pharmacopeia monographs.

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Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Physical and Chemical Properties of Differently Obtained Zn—Methionine Chelate with Proved Antibiofilm Properties (Part II)

et al. 2023

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Titanium Implant Modified With Zinc‐Doped Carbon Dot Layer as an Innovative Coating for the Development of Local Drug Delivery System for Ciprofloxacin

Reczkowski,

Ławniczak,

Ratajczak

et al. 2024

J Biomed Mater Res

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This study presents a new innovative drug delivery system for ciprofloxacin, which is based on the formation of a zinc‐doped carbon dots layer on the surface of a titanium alloy (TiAl4V6). In the study, the effectiveness of the synthesis method of a zinc‐doped carbon dots layer was determined. The distribution of the layer of carbon dots on the surface of the titanium alloy was investigated using the FT‐IR mapping technique, which confirmed the efficiency of the synthesis. The effective synthesis of carbon dots and the coordination of zinc ions on their surface opens the possibility of sorption of ciprofloxacin, which results in a high application potential of the obtained biomaterial. The introduction of zinc cations on the surface of the carbon dots layer resulted in high sorption results of the active substance (40 μg of drug per 1 cm2 of implant). The release profile of ciprofloxacin from the modified surface of the titanium alloy indicates that this active substance can be released for up to 4 h. The biomaterial obtained in this work is also hydrophilic (about 40°), which was shown by the contact angle tests. This is an important feature and indicates a high application potential of the performed modification. The resulting layer has antibacterial properties. Growth inhibition for microorganisms such as Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Bacillus cereus, and Candida albicans ranged from 74% to 96%. The creation of such a layer on the titanium alloy may reduce the risk of infection during the implantation procedure.

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High throughput LC/ESI-MS/MS method for simultaneous analysis of 20 oral molecular-targeted anticancer drugs and the active metabolite of sunitinib in human plasma

Hirasawa

Kikuchi

Takasaki

et al. 2023

Heliyon

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Analysis of Complexation Interactions between Metal Ions and Drugs under Pseudo-physiological pH Conditions by a High-throughput Screening Method Using a Solid-phase Extraction Cartridge

Cited by 7 publications

References 34 publications

Comparative Analysis of Physical and Chemical Properties of Differently Obtained Zn—Methionine Chelate with Proved Antibiofilm Properties (Part II)

Comparative Analysis of Physical and Chemical Properties of Differently Obtained Zn—Methionine Chelate with Proved Antibiofilm Properties (Part II)

Titanium Implant Modified With Zinc‐Doped Carbon Dot Layer as an Innovative Coating for the Development of Local Drug Delivery System for Ciprofloxacin

High throughput LC/ESI-MS/MS method for simultaneous analysis of 20 oral molecular-targeted anticancer drugs and the active metabolite of sunitinib in human plasma

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