Analysis of dose regimens efficacy of Dihydroartemisine-piperaquine in adults and children suffering from acute malaria in Cameroon

Abstract

Background: Magnetic nanoparticles (MNPs) have been a subject of great interest in recent years due to their potential biomedical applications as carriers for drug delivery, Among MNPs, superparamagnetic magnetite (Fe 3 O 4 ) has been particularly attractive due to its unique magnetic properties and biocompatibility Thus we have developed the MNPs drug delivery carrier against visceral leishmania.Methods & Materials: The functionalization of Fe 3 O 4 nanoparticles has been done with dendrimer and glycine was carried out in situ during co-precipitation of Fe 2 + and Fe 3 + ions in basic medium. The terminal amino acid on the shell of the magnetic nanocarriers allows us to create functionalized exteriors with high densities of organic moieties (both amine and carboxyl) for encapsulation of drug molecules. The drug-loading efficiency of the nanocarriers is investigated using amphoterecin B as a model drug to evaluate their potential as a carrier system.Results: Results and high loading affinity of nanocarriers for antileishmanial drug, their sustained release profile and during in vitro study, the mean 0.0801 ± 0.0251 of extracellular promastigote of amphoterecin B is significantly higher than MNPs encapsulated amphoterecin B 0.1129 ± 0.01499. Conclusion:Study signifies that there is an increased contact surface area of the drug and significant reduction in size, improved its efficacy than that of amphotericin B against visceral leishmania and invitro study also showing high affinity at low dose,Further this nanoformulations will be also good candidate as drug carriers for other infectious disease.