Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis

Abstract

Objective: To study whether the levels of 25-hydroxyvitamin D3 (25-(OH)D3) and Interleukin-1β (IL-1β) are correlated to the eradication and recurrence of helicobacter pylori (Hp) in paediatric patients with Hp infection-related gastritis.
 Methods: A total of 142 paediatric patients with Hp infection-related gastritis from November 2017 to March 2018 in Baoding Children’s Hospital were selected as study subjectswere selected as study subjects and were followed up for one year. Paediatric patients were grouped and analyzed according to the effect of follow-up treatment and recurrence.
 Results: The levels of 25-(OH) D3 in the non-eradication group were lower than those in the eradication group and the control group (F=27.087, P<0.05); the levels of IL-1β were higher than those in the eradication group and the control group (F=16.610, P<0.05). Recurrence during follow-up visits: The levels of 25-(OH) D3 in the recurrence group were lower than those in the non-recurrence group and the control group (F=33.837, P<0.05); the levels of IL-1β in the recurrence group were higher than those in the non-recurrence group and the control group (F=7.896, P<0.05). Correlation analysis showed the levels of 25-(OH) D3 and IL-1β in the eradication group and the non-eradication group were negatively correlated (r=-0.232, P<0.05); the levels of 25-(OH) D3 and IL-1β in the recurrence group and the non-recurrence group were negatively correlated (r=-0.225, P<0.05).
 Conclusion: Relatively high levels of IL-1β may be correlated to the difficulty in eradicating the Hp infection in paediatric patients. Relatively low levels of 25-(OH) D3 may be correlated to the difficulty in eradicating the Hp infection and recurrence in paediatric patients.
 doi: https://doi.org/10.12669/pjms.36.6.2292
 How to cite this:Zhang Y, Bi B, Guo X, Zhang S. Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis. Pak J Med Sci. 2020;36(6):---------. doi: https://doi.org/10.12669/pjms.36.6.2292
 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Effects of inflammatory cytokines on eradication and recurrence of Helicobacter pylori infection in children

“…6,13,14 Moreover, the genetic polymorphism of IL-1β was associated with chronic atrophic gastritis and gastric cancer, 15 and relatively higher IL-1β level may be one of the reasons for the failure of eradication in children with Hp infection. 16 Our results showed that, after triple therapy, the Hp-infected children with the failure of eradication had higher IL-1β levels than Hp-infected children with the success of eradication, which was consistent with previous reports, revealing that relatively high IL-1β level may affect the eradication effect of triple therapy.…”

Vitamin D and Its Association with H. pylori Prevalence and Eradication: A Comprehensive Review

“…Zhang et al found the lowest vitamin D serum values among a pediatric population with H. pylori recurrence, despite adequate treatment. Within their study, significantly higher values of the same parameter were found in those patients in whom bacterial eradication was successful and in healthy controls, but each of the analyzed study groups had a low percentage of vitamin D-deficient and -insufficient individuals [ 51 ]. Sorokman et al found that vitamin D levels of over 20 ng/mL are more likely to ensure eradication success.…”

“…The main population benefitting from regular vitamin D supplementation belongs to the pediatric segment. However, the limited number of pediatric studies performed on this subject did not offer any information regarding the regularity, amount, and/or adequacy of the intake of vitamin D supplements within the analyzed study populations [ 40 , 41 , 42 , 43 , 51 ]. Hence, future prospective studies and randomized controlled trials are required to clarify the relationship between vitamin D serum levels, its supplementation, and H. pylori, and to evaluate whether the addition of vitamin D3 to therapeutic regimens influences bacterial eradication.…”

“…Pediatric studies could provide more insight into this matter, given that vitamin D supplements are routinely administered in children [ 68 ]. The data available so far for pediatric ages did not provide any information regarding the amount of vitamin D supplementation that the enrolled populations were receiving [ 40 , 41 , 42 , 43 , 51 ].…”

Improvement of Eradication Therapy in Children With Duodenal Ulcer Associated With Helicobacter Pylori

“…H. pylori and VitD have been suggested to be associated with gastric VitD receptors and a systemic immune response to chronic gastritis [31]. A previous study [32] showed that serum VitD levels in patients with H. pylori-associated gastritis lower. Several studies have examined the incidence of H. pylori infection in patients with varying levels of VitD [33].…”