Analysis of genetic polymorphisms at the interleukin‐10 loci in aggressive and chronic periodontitis

Gonzáles, José R.; Michel, J.; Diete, A.; Herrmann, Jens; Bödeker, Rolf‐Hasso; Meyle, Joerg

doi:10.1034/j.1600-051x.2002.290905.x

Cited by 55 publications

(71 citation statements)

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“…Racial and ethnic characteristics play a role on these results. Gonzales et al 4 searched gene polymorphism in IL-10(-592) loci in AgP and CP Caucasian patients. Contrary to our results, they found no association between IL-10 AA genotype and AgP; similar results were found by Hu et al 23 in Chinese population.…”

Section: Discussionmentioning

confidence: 99%

“…4,21,24 The IL-10 gene polymorphism at position -597 C to A wasnot associated with the susceptibility to CP or AgP. 4 Considering the key roles of pro-inflammatory and anti-inflammatory cytokines in periodontal disease, it was questioned whether genetic variations affecting transcription or function of these cytokines contribute to the development of GAgP. Also, few studies have investigated the potential association of carrying a gene variant with the clinical response to periodontal therapy.…”

Section: Introductionmentioning

confidence: 99%

“…2 The genetic risk of AgP development has been investigated in many studies in various populations. 3,4,5 Declaration of Interests: The authors certify that they have no commercial or associative interest that represents a conflict of interest in connection with the manuscript.…”

Section: Introductionmentioning

confidence: 99%

“…23 In the literature, data on which of the IL-10 polymorphisms or variations contributes to periodontal disease are contradictory. 4,21,24 The IL-10 gene polymorphism at position -597 C to A wasnot associated with the susceptibility to CP or AgP. 4 Considering the key roles of pro-inflammatory and anti-inflammatory cytokines in periodontal disease, it was questioned whether genetic variations affecting transcription or function of these cytokines contribute to the development of GAgP.…”

Section: Introductionmentioning

confidence: 99%

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IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters

et al. 2017

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“…However, the presence of an association between IL-10 gene polymorphisms and clinical manifestations of chronic and aggressive periodontitis is controversial. Some of the studies failed to find any evidence of association (4,19,20) and others revealed a possible association between this polymorphism and periodontitis (17,(21)(22)(23)(24). Considering the multifactorial nature of a periodontal disease, little is known among the complex interaction of the polymorphisms in the promoter regions of IL-6 (-174), IL-10 (-597) and NF-κB1 (-94ins/del) genes and clinical parameters of periodontitis.…”

Section: Introductionmentioning

confidence: 99%

Analysis of IL-6, IL-10 and NF-κB Gene Polymorphisms in Aggressive and Chronic Periodontitis

Toker¹,

Görgün²,

Korkmaz³

2017

Cent Eur J Public Health

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SUMMARYObjective: Pro-inflammatory cytokines, interleukin-6 (IL-6), demonstrated to be suppressed by interleukin-10 (IL-10) are known to be regulated by the transcription factor nuclear factor-κB(NF-κB). The aim of this study was to ascertain the association between genetic polymorphism of these genes (IL-6(-174), IL-10(-597) and NF-κB1-94ins/del)) and chronic/aggressive periodontitis.Methods: Forty-five patients with chronic periodontitis (CP), 58 patients with aggressive periodontitis (AP) and 38 periodontally healthy subjects were included in this study. Genomic DNA was isolated from whole blood samples. The NF-κB, IL-6, and IL-10 polymorphisms were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.Results: Among subjects for the ins/ins genotypes of NF-κB1 gene, the AA genotypes of IL-10 presented a higher frequency in chronic periodontitis group than in healthy controls (p = 0.023). A statistically significant difference in genotyping frequencies between AP group and healthy controls was observed for the IL-6 gene. The AA genotype of IL-10 was overrepresented in CP and AP groups compared to healthy controls (OR = 9.93, 95% CI: 2.11-46.7, OR = 5.7, 95% CI: 1.22-26.89, respectively).Conclusions: Within the limits of this study, it can be concluded that the IL-10 (-597) AA genotype is associated with susceptibility to chronic/ aggressive periodontitis and IL-6 (-174) GG genotypes and G allele seems to be associated with aggressive periodontitis.Clinical relevance: The results of the current study indicate that IL-6 and IL-10 genotypes seem to be associated with aggressive periodontitis. Also, the AA genotypes of IL-10 presented a higher frequency in chronic periodontitis subjects with carrying NF-κB1 ins/ins genotypes.

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Modifying Disease Genes in Relation to Periodontitis

Dumitrescu¹,

Kobayashi²

2009

Genetic Variants in Periodontal Health and Disease

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Analysis of genetic polymorphisms at the interleukin‐10 loci in aggressive and chronic periodontitis

Abstract: We conclude that the investigated polymorphisms are not associated with periodontal disease.

Cited by 55 publications

References 40 publications

IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters

IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters

Analysis of IL-6, IL-10 and NF-κB Gene Polymorphisms in Aggressive and Chronic Periodontitis

Modifying Disease Genes in Relation to Periodontitis

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