Analysis of genotype effects for the immunosuppression via two-step method

Abstract

Abstract. This paper studies the main effects and interactive effects between genes on immunosuppression susceptibility caused by ultraviolet radiation in population of mice. We present a two-step strategy, i.e., we first establish one full linear model based on all main effects and interactive effects, and use the Dantzig selector method to screen the genotype effects preliminary; then via the idea of stepwise regression, under the other model we further detect the significant main effects and interactive effects for the UV-induced immunosuppression susceptibility. The most significant main effect site that we identified is D10Mit170, and the most significant interactive sites are D6Mit389 and D16Mit131.