Analysis of gut microbiota and metabolites in patients with rheumatoid arthritis and identification of potential biomarkers

Chen, Yumei; Ma, Chiyu; Liu, Lixiong; He, Jingquan; Zhu, Chaowei; Zheng, Fengping; Dai, Weier; Hong, Xiaoping; Liu, Dongzhou; Tang, Donge; Dai, Yong

doi:10.18632/aging.203641

Cited by 43 publications

(36 citation statements)

References 31 publications

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“…However, studies have shown that patients with multiple sclerosis may have a uniform decrease in Prevotellaceae , especially the genus Prevotella [ 28 , 29 ]. Similarly, a study on Chinese RA patients showed them to have decreased Prevotella [ 30 ]. The Prevotellaceae family may be beneficial for enhancing the production of protective short chain fatty acids (SCFAs), such as butyrate and propionate, which are bacterial metabolites that expand gut regulatory T cells (Tregs) [ 28 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Characteristics of gut microbiota in patients with primary Sjögren’s syndrome in Northern China

Sun

et al. 2022

PLoS ONE

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This study analyzes and compares the structure and diversity of gut microbiota in patients with primary Sjögren’s syndrome (pSS) in Northern China to healthy individuals to identify clinical features associated with dysbiosis. We included 60 Chinese pSS patients and 50 age- and gender-matched healthy controls. DNA was extracted from stool samples and subjected to 16S ribosomal RNA gene analysis (V3-V4) for intestinal dysbiosis. In addition, patients were examined for laboratory and serological pSS features. A Spearman’s correlation analysis was performed to assess correlations between individual bacteria taxa and clinical characteristics. The alpha-diversity (Chao1 and Shannon Index) and beta-diversity (unweighted UniFrac distances) of the gut microbiota differed significantly between pSS patients and healthy controls. Further analysis showed that several gut opportunistic pathogens (Bacteroides, Megamonas, and Veillonella) were significantly more abundant in pSS patients and positively correlated with their clinical indicators. In contrast, some probiotic genera (Collinsella, unidentified_Ruminococcaceae, Romboutsia, and Dorea) were significantly decreased in pSS patients and negatively correlated with their clinical indicators. Therefore, pSS patients in Northern China showed a dysbiotic intestinal microbiome enriched for potentially pathogenic genera that might be associated with autoimmune disease.

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Section: Discussionmentioning

confidence: 99%

Characteristics of gut microbiota in patients with primary Sjögren’s syndrome in Northern China

Sun

et al. 2022

PLoS ONE

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“…Gut dysbiosis may lead to alterations in fecal metabolites, and a deficiency of beneficial bacteria and their metabolites may stimulate the inflammatory response (Yu et al, 2021). Among gut bacterial metabolites, SCFAs, amino acids, and their metabolites have been implicated in the pathogenesis of RA (Chen et al, 2021).…”

Section: Cross-talk Between Microbiota-derived Metabolites and Immune...mentioning

confidence: 99%

Gut-joint axis: Gut dysbiosis can contribute to the onset of rheumatoid arthritis via multiple pathways

Romero-Figueroa

Ramírez-Durán²,

Montiel-Jarquín³

et al. 2023

Front. Cell. Infect. Microbiol.

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Rheumatoid Arthritis (RA) is an autoimmune disease characterized by loss of immune tolerance and chronic inflammation. It is pathogenesis complex and includes interaction between genetic and environmental factors. Current evidence supports the hypothesis that gut dysbiosis may play the role of environmental triggers of arthritis in animals and humans. Progress in the understanding of the gut microbiome and RA. has been remarkable in the last decade. In vitro and in vivo experiments revealed that gut dysbiosis could shape the immune system and cause persistent immune inflammatory responses. Furthermore, gut dysbiosis could induce alterations in intestinal permeability, which have been found to predate arthritis onset. In contrast, metabolites derived from the intestinal microbiota have an immunomodulatory and anti-inflammatory effect. However, the precise underlying mechanisms by which gut dysbiosis induces the development of arthritis remain elusive. This review aimed to highlight the mechanisms by which gut dysbiosis could contribute to the pathogenesis of RA. The overall data showed that gut dysbiosis could contribute to RA pathogenesis by multiple pathways, including alterations in gut barrier function, molecular mimicry, gut dysbiosis influences the activation and the differentiation of innate and acquired immune cells, cross-talk between gut microbiota-derived metabolites and immune cells, and alterations in the microenvironment. The relative weight of each of these mechanisms in RA pathogenesis remains uncertain. Recent studies showed a substantial role for gut microbiota-derived metabolites pathway, especially butyrate, in the RA pathogenesis.

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“…Novel sensitive therapeutics can be developed to target key enzymes in metabolic pathways. With the progression of multi-omics technology, integrative analysis of metabolomics with proteomics, transcriptome, genomics, and 16S rRNA gene sequencing can provide insight into RA ( 128 , 129 ) and lead to precision medicine.…”

Section: Limitations and Outlookmentioning

confidence: 99%

Metabolomics in rheumatoid arthritis: Advances and review

Chang

Jiang

et al. 2022

Front. Immunol.

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Rheumatoid arthritis (RA) is an autoimmune disease accompanied by metabolic alterations. The metabolic profiles of patients with RA can be determined using targeted and non-targeted metabolomics technology. Metabolic changes in glucose, lipid, and amino acid levels are involved in glycolysis, the tricarboxylic acid cycle, the pentose phosphate pathway, the arachidonic acid metabolic pathway, and amino acid metabolism. These alterations in metabolic pathways and metabolites can fulfill bio-energetic requirements, promote cell proliferation, drive inflammatory mediator secretion, mediate leukocyte infiltration, induce joint destruction and muscle atrophy, and regulate cell proliferation, which may reflect the etiologies of RA. Differential metabolites can be used as biomarkers for the diagnosis, prognosis, and risk prediction, improving the specificity and accuracy of diagnostics and prognosis prediction. Additionally, metabolic changes associated with therapeutic responses can improve the understanding of drug mechanism. Metabolic homeostasis and regulation are new therapeutic strategies for RA. In this review, we provide a comprehensive overview of advances in metabolomics for RA.

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Analysis of gut microbiota and metabolites in patients with rheumatoid arthritis and identification of potential biomarkers

Cited by 43 publications

References 31 publications

Characteristics of gut microbiota in patients with primary Sjögren’s syndrome in Northern China

Characteristics of gut microbiota in patients with primary Sjögren’s syndrome in Northern China

Gut-joint axis: Gut dysbiosis can contribute to the onset of rheumatoid arthritis via multiple pathways

Metabolomics in rheumatoid arthritis: Advances and review

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