Analysis of HPV Genotypes and Liquid-Based Cervical Cytology: Results from a Tertiary Academic Center in Northwestern Turkey

Çalışkan, Emel; Coşkun, Şule; Öztürk, Cihadiye Elif; Cangür, Şengül; Önail, Binnur

doi:10.7883/yoken.jjid.2020.072

Cited by 2 publications

(3 citation statements)

References 9 publications

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Section: Resultssupporting

confidence: 92%

“…The HPV positivity rates in our results were similar to those reported in previous studies conducted in Turkey 20 - 22 . For instance, Çalişkan et al 22 found an HPV positivity of 42 per cent in consecutive cervical specimens by real-time PCR. In two other studies, HPV types were determined in patients who presented to the clinic with various gynaecological complaints (menstrual irregularity, dyspareunia, vaginal discharge, lower abdominal pain and post-coital bleeding) 20 , 21 .…”

Section: Resultssupporting

confidence: 92%

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High-risk human papillomavirus in Turkish patients with clinically suspicious cervical lesions analyzed by multiplex-PCR

Gorur¹,

Dolanbay²,

Öztürk³

et al. 2022

Indian Journal of Medical Research

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Background & objectives: Human papillomavirus (HPV) infection is known to be the main cause of cervical cancer. This study aimed to determine the prevalence of high-risk HPV genotypes in smear specimens taken from women who had normal or abnormal cytology using a multiplex PCR method. Methods: The study included 270 women aged between 19 and 69 yr with or without suspicious cervical abnormalities. A Pap smear sample from each patient was cytologically examined, and HPV typing was performed using a multiplex fluorescent PCR method. Those who were high-risk HPV positive and had a normal or abnormal cytology were further evaluated by colposcopy and biopsy. Results: The total HPV positivity was 43 per cent (116/270). HPV positivity in the patients with an abnormal cytology was 77 per cent (33/43), whereas it was only 37 per cent (83/227) in women with normal cytology, which showed a significant difference ( P <0.05). HPV positivity was also related to the age group when all the subjects were considered ( P <0.05), and the highest prevalence of HPV infection was in the 30-39 yr age group. High-risk HPV types 16, 18, 31, 35, 51 and 56 were more common in the normal cytology patients, whereas high-risk HPV types 16, 31, 35, 45, 58 and 68 were commonly found in the abnormal cytology patients. Interpretation & conclusions: The determination of high-risk HPV genotypes in women with clinically suspicious cervical lesions should be conducted during an annual follow-up, irrespective of a normal or abnormal cytology by the age of 30 years or above.

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Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 92%

High-risk human papillomavirus in Turkish patients with clinically suspicious cervical lesions analyzed by multiplex-PCR

Gorur¹,

Dolanbay²,

Öztürk³

et al. 2022

Indian Journal of Medical Research

View full text Add to dashboard Cite

show abstract

“…respectively). 16,17 This could be explained by the prevalent and incident cases discovered in our sample, in contrast to only incident cases found in regularly tested women found in that studies and also in our sample, majority of women were symptomatic (89.7%) and the frequency of abnormal cytological result in symptomatic women was higher and this proved by many study. 18,19 The prevalence of abnormal cytology result showed a bimodal age pattern result which not in line to that reported in some other populations, where shown increased in prevalence of abnormal cytology with increasing age.…”

Section: Discussioncontrasting

confidence: 63%

HPV co-testing as cervical screening test, Experience of Alweiya early detection cervical clinic: one-year Analysis

Al-Jobawi

Ali

Al-Niyazee

et al. 2020

J. Contemp. Med. Sci.

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Objectives: The high-risk Human papilloma virus test with conventional cytology (HPVco-test) was firstly introduced in our institute at May 2019 so we aimed to estimate the prevalence of abnormal cytology and positive high-risk human papillomavirus test results in a screening woman and to assess the accuracy between cytology and Human papilloma virus testing to evaluate the feasibility of integrating the latter as a primary test in the national cervical cancer screening program. Methods: A prospective study for women attending to early detection cervical clinic, during the period from May 2019 to May 2020. Patients who were sexually active were included in the study. Samples for conventional cytology and HPV by using real-time polymerase chain reaction technique for high risk types were taken concurrently. The prevalence of positive screening results and the difference in accuracy between two testing were estimated by McNemar’s χ2 test. Result: A total of 388 women were included in the study. The prevalence of positive test for hr-HPV was 2.1%(8) while the prevalence of abnormal cytology test was 19.1%(74), Concerning discordant pairs, 0.8%(3) of women had normal cytology with a positive hr-HPV test result and 17.8%(69) of women had abnormal cytology with a negative hr-HPV test result. A total of 311 (80.1%) women had normal cytology and negative hr-HPV test results. The proportion of women with abnormal cytology and positive hr-HPV test results was 1.3% (5 women). the difference in accuracy between the two results was statistically significant (<0.0001). The prevalence of positive hr-HPV test decreased with increasing age, whereas the prevalence of abnormal cytology showed a bimodal age pattern. Conclusion: The prevalence of abnormal cytology was high to that of hr-HPV testing, which could not allow for the implementation of hr-HPV as a primary test in the national screening program in Iraq.

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Analysis of HPV Genotypes and Liquid-Based Cervical Cytology: Results from a Tertiary Academic Center in Northwestern Turkey

Cited by 2 publications

References 9 publications

High-risk human papillomavirus in Turkish patients with clinically suspicious cervical lesions analyzed by multiplex-PCR

High-risk human papillomavirus in Turkish patients with clinically suspicious cervical lesions analyzed by multiplex-PCR

HPV co-testing as cervical screening test, Experience of Alweiya early detection cervical clinic: one-year Analysis

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