Analysis of MHC Class II antigens in Japanese IDDM by a novel HLA-typing method, hybridization protection assay

Relationship of Type 1 Diabetes with Human Leukocyte Antigen (HLA) Class II Antigens Except for DR3 and DR4

“…Conversely, the DR8 haplotype confers susceptibility to Japanese T1D (Awata et al, 1992;Kawabata et al, 2002;Kobayashi et al, 1993;Murao et al, 2004;Ohtsu et al, 2005;Yasunaga et al, 1996) and is present only in Japanese and Korean T1D (Thomson et al, 2007). However, some studies have found no evidence that the DR8 haplotype confers susceptibility to Japanese T1D (Maruyama et al, 1994;Murao et al, 2004;Tanaka et al, 2002). Table 5 shows the phenotype frequency of the DR8 haplotype and the mean onset age of T1D in previous studies.…”

“…are the most frequently observed susceptibility haplotypes in the Japanese (Awata et al, 1992;Kawabata et al, 2002;Kobayashi et al, 1993;Maruyama et al, 1994;Murao et al, 2004;Tanaka et al, 2002;Yasunaga et al, 1996). However, studies conducted before the discovery of fulminant T1D may have included patients with fulminant T1D.…”

“…Therefore, it is possible that the A2 type of diabetes is associated with HLA. Previous studies investigating the relationship between HLA class II genes and slow-onset T1D in Japan have focused on the relationship between these genes and the A2 type of diabetes (Kobayashi et al, 1993;Maruyama et al, 1994;Murao et al, 2004;Ohtsu et al, 2005) .…”

“…A nationwide survey in Japan revealed that 41.8% of fulminant T1D patients possessed the DR4-DQ4 (encoded by DRB1*04:05-DQA1*03:03-DQB1*04:01) haplotype . Table 4 shows the phenotype frequencies of DRB1*04:05-DQA1*03:03-DQB1*04:01 and DR9 haplotypes in rapid-onset T1D with fulminant T1D (A0 + A1 + B0 + B1 areas) (Awata et al, 1992;Kawabata et al, 2002;Kobayashi et al, 1993;Maruyama et al, 1994;Yasunaga et al, 1996), rapid-onset T1D (which includes A1 area and excludes B0 area) Murao et al, 2004;, and fulminant T1D (B0 area) Tanaka et al, 2002 Before the existence of fulminant T1D was clarified (Imagawa et al, 2000a), the frequency and odds ratio (OR) of the DRB1*04:05-DQA1*03:03-DQB1*04:01 haplotype were higher than those of the DR9 haplotype in rapid-onset T1D with fulminant T1D (Awata et al, 1992;Kawabata et al, 2002;Kobayashi et al, 1993;Maruyama et al, 1994;Yasunaga et al, 1996). However, the frequency and OR of the DRB1*04:05-DQA1*03:03-DQB1*04:01 haplotype in rapid-onset T1D are lower than those of the DRB1*04:05-DQA1*03:03-DQB1*04:01 haplotype in rapid-onset T1D with fulminant T1D and those of the DR9 haplotype in rapid-onset T1D Murao et al, 2004;Tanaka et al, 2002).…”

Glutamic Acid Decarboxylase65 (GAD65) Antibodies and Insulin Auto-Antibodies in Japanese Patients with Nonlnsulin-Dependent Diabetes Mellitus.

“…Indeed, ICA is reportedly a good marker for the development of insulin-dependency in noninsulin-dependent adult onset diabetic patients [7,8,14,15]. Since ICA positive-patients show gradually decreasing C-peptide levels necessitating insulin treatment [8] and share the HLA class II type associated with susceptibility to IDDM [16,17], the pathogenesis has been speculated to be similar to that of patients with IDDM. Although predictability is high, ICA assays are time consuming, expensive, and difficult to standardize.…”