Analysis of microarchitectural changes in a mouse temporomandibular joint osteoarthritis model

Chen, J.; Gupta, T.; Barasz, J.A.; Kalajzić, Žana; Yeh, Wei-Chen; Drissi, Hicham; Hand, Arthur R.; Wadhwa, Sunil

doi:10.1016/j.archoralbio.2009.10.001

Cited by 28 publications

(27 citation statements)

References 31 publications

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“…Six studies applied in vivo micro-CT, performed in the maxilla [6], [15], [20], [21] and in the condyle [10], [22]. The scanning device which was most often used was the μCT 40 (Scanco Medical, Brüttisellen, Switzerland) [9], [11], [13], [14], [19], [23], [24], [25], [26], [27], [28], [29], [30], [31], followed by the Skyscan apparatus (Skyscan, Aartselaar, Belgium) [3], [4], [8], [20], [21], [32], [33], [34], [35]. The results of the quantitative analysis are presented in Table 2, Table 3, Table 4.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 3 papers investigated the effect of forced mouth opening on mandibular condyle structure, in both male and female rats [26], [28], [45]. Two longitudinal studies [10], [22] on condylar micro-architectural changes in response to experimental interventions such as osteoporosis and occlusal loading were retrieved.…”

Section: Resultsmentioning

confidence: 99%

“…The paper of Jiao et al (2010) assessed the impact of age and sex on the condylar bone micro-architecture [47]. Finally, the osteoarthritis model was applied in one study [28]. With regard to the timing of publication, again the articles were published quite recently, with the earliest one in 2006 (2013 (n = 2); 2012 (n = 1); 2011 (n = 3); 2010 (n = 2); 2009 (n = 2); 2007 (n = 1) and 2006 (n = 1)).…”

Section: Resultsmentioning

confidence: 99%

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Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review

et al. 2015

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IntroductionKnowledge about macro- and micro-structural characteristics may improve in vivo estimation of the quality and quantity of regenerated bone tissue. For this reason, micro-CT imaging has been applied to evaluate alveolar bone remodelling, alterations of periodontal ligament thickness and cortical and trabecular bone changes in rodent jaw bones. In this paper, we provide a systematic review on the available micro-CT literature on jaw bone micro-architecture.MethodologyA detailed search through the PubMed database was performed. Articles published up to December 2013 and related to maxilla, mandible and condyle with quantitatively analysed bone micro-architectural parameters were considered eligible for inclusion. Two reviewers assessed the search results according to inclusion criteria designed to identify animal studies quantifying the bone micro-architecture of the jaw rodent bones in physiological or drug-induced disease status, or in response to interventions such as mechanical loading, hormonal treatment and other metabolic alterations. Finally, the reporting quality of the included publications was evaluated using the tailored ARRIVE guidelines outlined by Vignoletti and Abrahamsson (2012).ResultsDatabase search, additional manual searching and assessment of the inclusion and exclusion criteria retrieved 127 potentially relevant articles. Eventually, 14 maxilla, 20 mandible and 12 condyle articles with focus on bone healing were retained, and were analysed together with 3 methodological papers. Each study was described systematically in terms of subject, experimental intervention, follow-up period, selected region of interest used in the micro-CT analysis, parameters quantified, micro-CT scanner device and software. The evidence level evaluated by the ARRIVE guidelines showed high mean scores (between 18 and 25; range: 0–25), indicating that most of the selected studies are well-reported. The major obstacles identified were related to sample size calculation, absence of adverse event descriptions, randomization or blinding procedures.ConclusionsThe evaluated studies are highly heterogeneous in terms of research topic and the different regions of interest. These results illustrate the need for a standardized methodology in micro-CT analysis. While the analysed studies do well according to the ARRIVE guidelines, the micro-CT procedure is often insufficiently described. Therefore we recommend to extend the ARRIVE guidelines for micro-CT studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review

et al. 2015

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“…We postulate that these early alterations of extracellular matrix components lead to biomechanically compromised chondro-osseous tissue which is then susceptible to later stage damage by loading forces that occur during joint use. The validity of this argument is strengthened by studies of biglycan and fibromodulin single and double knock-out mouse models which show age dependent cartilage biomechanical changes with histologic and clinical features of osteoarthritis [21][22][23]. In addition, human genetic association studies have identified polymorphisms in other single extracellular matrix genes such as COMP [24], OPN [25], and SDC4 [26] which appear to predispose individuals to late-stage osteoarthritis [27].…”

Section: Discussionmentioning

confidence: 99%

Extracellular matrix disruption is an early event in the pathogenesis of skeletal disease in mucopolysaccharidosis I

Heppner

Zaucke

Clarke

2015

Molecular Genetics and Metabolism

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“…The SAMP3 strain shows not only an early and high incidence of severe degeneration in the TMJ, but these changes start at three months of age 6) . One of the severe pathological changes in TMD is a destruction of the joint cartilage, known as osteoarthritis (OA), which is characterized by degradation and erosion along the surface of articular cartilage 7) and results in changes to the subchondral bone structure 8) .…”

Section: Introductionmentioning

confidence: 99%

TMJ Degenerative Changes in SAMP3 Mice by Occlusal Disharmony and Aging

Elshawi

Wakamatsu

Iinuma

et al. 2012

J. Hard Tissue Biology.

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Aging and mechanical loading by occlusal disharmony are critical and etiological factors for the onset of temporomandibular joint disorders (TMDs). Senescence-accelerated mouse prone 3 (SAMP3) is one of the animal models for studying age-related degenerative changes of various tissues and organs. To evaluate the influences of both the aging and/or the mechanical loading induced by occlusal disharmony on the SAMP3 TMJ condyle, histological and immunohistochemical analyses were performed.Fifty-five, 4-week-old SAMP3 mice were divided into two groups as an experimental and control. In the experimental group, the maxillary molars were trimmed out from the occlusal plane, which also served as mechanical force loading on the condylar surface. Then the condyles were removed and proceeded for histological and immunohistochemical analysis. The subchondral bone ossification was also evaluated by micro-focusing computed tomography (micro-CT) analysis.The results indicated that induced occlusal disharmony in an aging background promotes TMD, including osteoarthritis (OA) like disease. OA-like TMJ lesions in the SAMP3 mice, accompanied by mandibular condylar cartilage degradation, were characterized by loss of proteoglycans (PGs) and changes of the localization of the extracellular matrix, such as collagen type I, II and MMP13. Changes in the microarchitecture of the condyle were also caused under OA-like lesion. Disrupted Wnt/ -catenin signaling by means of immunohistochemical analysis of -catenin contributes to this irreversible cartilage tissue damage.The present study indicates that the experimentally induced occlusal disharmony (under the age-related background) promotes the TMJ OA accompanied by the alteration to components of the extracellular matrix, and Wnt/ -catenin signaling disorder contributes to these irreversible cartilage tissue damage.

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Analysis of microarchitectural changes in a mouse temporomandibular joint osteoarthritis model

Cited by 28 publications

References 31 publications

Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review

Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review

Extracellular matrix disruption is an early event in the pathogenesis of skeletal disease in mucopolysaccharidosis I

TMJ Degenerative Changes in SAMP3 Mice by Occlusal Disharmony and Aging

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