Analysis of Mouse Eosinophil Migration and Killing of Tumor Cells

Grisaru, Sharon; Itan, Michal; Munitz, Ariel

doi:10.1007/978-1-0716-1095-4_8

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…Renata et al ( Rossetti et al, 2018 ) demonstrated that activated B cells could induce antigen specific T cell responses and play an antitumor role. Similarly, activated CD8 + T cells and eosinophils can inhibit tumor growth in different ways ( Wieckowski et al, 2009 ; Grisaru et al, 2021 ). In addition, previous research showed that a high number of Th2 cells was associated with poor prognosis in tumors ( De Monte et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of the Expression Patterns and Potential Prognostic Role of 5-Methylcytosine Regulators in Hepatocellular Carcinoma

Liu

Zheng

Wang

et al. 2022

Front. Cell Dev. Biol.

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Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a poor prognosis. 5-methylcytosine (m5C) modification plays a nonnegligible role in tumor pathogenesis and progression. However, little is known about the role of m5C regulators in HCC.Methods: Based on 9 m5C regulators, the m5C modification patterns of HCC samples extracted from public databases were systematically evaluated and correlated with tumor immune and prognosis characteristics. An integrated model called the “m5Cscore” was constructed using principal component analysis, and its prognostic value was evaluated.Results: Almost all m5C regulators were differentially expressed between HCC and normal tissues. Through unsupervised clustering, three different m5Cclusters were ultimately uncovered; these clusters were characterized by differences in prognosis, immune cell infiltration, and pathway signatures. The m5Cscore was constructed to quantify the m5C modifications of individual patients. Subsequent analysis revealed that the m5Cscore was an independent prognostic factor of HCC and could be a novel indicator to predict the prognosis of HCC.Conclusion: This study comprehensively explored and systematically profiled the features of m5C modification in HCC. m5C modification patterns play a crucial role in the tumor immune microenvironment (TIME) and prognosis of HCC. The m5Cscore provides a more holistic understanding of m5C modification in HCC and provides a practical tool for predicting the prognosis of HCC. This study will help clinicians identify effective indicators of HCC to improve the poor prognosis of this disease.

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