Analysis of Myelin Using the Resonant Recognition Model

Abstract

Both Multiple Sclerosis (MS) and possibly Alzheimer Disease (AD) are caused by damage of myelin sheath, which is an insulating layer of lipids and proteins surrounding nerves. By using the Resonant Recognition Model (RRM), which can identify critical parameters for function/interaction of biological molecules, we have analysed here all the participants in the formation and stability of myelin with the aim to understand its complex function. Interestingly, we have identified here that all participants in myelin formation and stability do have only one common RRM frequency, indicating that this RRM frequency is critical for myelin formation and stability. With such identified RRM characteristic frequency, the next step would be to design de novo bioactive peptides, which might be able to facilitate repair of damaged myelin and could lead to new possible treatment of MS and AD.