Analysis of parenchymal density on mammograms in 1353 women 25-79 years old.

Stomper, Paul C.; D'Souza, David; DiNitto, P A; Arredondo, Mark A.

doi:10.2214/ajr.167.5.8911192

Cited by 241 publications

(176 citation statements)

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“…107 It has been suggested that the lower sensitivity for women aged 40-49 years compared to older women may result from the more radiographically dense breasts observed in younger women. 113 An alternative explanation for the lower screening sensitivity for younger women (aged 40 -49 years) is that the rapid tumor growth rates in younger women result in the diagnosis of interval cancers. Indeed, the results of one study now suggest that African American women, particularly those under the age of 65 years, may have a higher prevalence of dense breasts than observed in other groups.…”

Section: Adequacy Of Current Screening Guidelines For Young African Amentioning

confidence: 99%

Mammography screening in African American women

Jones

Patterson²,

Calvocoressi

2002

Cancer

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Section: Adequacy Of Current Screening Guidelines For Young African Amentioning

confidence: 99%

Mammography screening in African American women

Jones

Patterson²,

Calvocoressi

2002

Cancer

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“…Mammographic sensitivity declined significantly with increasing breast density (Kolb et al, 2002;Caney et al, 2003;Devolli-Disha et al, 2009). As known, dense breast tissue is common: approximately half of women younger than 50 years and a third of older women have dense breast parenchyma (Stomper et al, 1996). Compared to European breasts, Thai breasts differ in the composition of breast tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Data from the present study (74.8% and 10.2%) also supported a previous report. It is well accepted that mammographic density declines progressively with age, especially after menopause and because the breast tissue becomes less dense and more fatty in women in this age, mammography might be easier to be interpreted (Stomper et al, 1996;Boyd et al, 2002;Carney et al, 2003;Titus-Ernstoff et al, 2006). Mammographic sensitivity declined significantly with increasing breast density and in younger women with dense breasts (Kerlikowske et al, 1996;Kolb et al, 2002;Carney et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Mammography in Combination with Breast Ultrasonography Versus Mammography Alone for Breast Cancer Screening in Asymptomatic Women

Boonlikit¹

2013

Asian Pacific Journal of Cancer Prevention

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“…Essa associação foi considerada signifi cante. Este fato também foi observado por outros autores 14,16,26 .…”

Section: Densidadesunclassified

“…A maioria das mulheres (81-70,4%) tinha mamas lipossubstituídas (provavelmente devido a cessação na divisão celular mamária), com interrupção dos níveis de hormônios endógenos, o que está de acordo com a literatura 14,16,25,26 . Encontramos associação próxima da signifi cância estatística entre menopausa e densidade mamográfi ca.…”

Section: Densidadesunclassified

Associação entre os polimorfismos HaeIII e MspI do gene para o receptor alfa de estrogênio e densidade mamográfica em mulheres após a menopausa

Ramos¹,

Kemp

Silva³

2006

Rev. Bras. Ginecol. Obstet.

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RESUMOObjetivo: Avaliar a presença dos polimorfi smos HaeIII e MspI do gene para o receptor de estrogênio alfa, bem como fatores clínicos e suas possíveis associações com a densidade mamográfi ca em mulheres após a menopausa. Métodos: Foram avaliadas 115 mulheres após a menopausa, não usuárias de terapia hormonal e sem lesão mamária clínica ou mamografi camente identifi cada. A densidade mamográfi ca foi determinada por três observadores independentes, tomando-se como base a classifi cação dos padrões mamográfi cos do ACR-BIRADS ® , 2003 (duas avaliações subjetivas e uma computadorizada -Adobe Photoshop ® 7.0). Amostras de raspado bucal foram obtidas para extração de DNA e em seguida foi realizada uma PCR-RFLP (Polymerase Chain Reation -Restriction Fragment Length Polymorphism) para análise de polimorfi smos presentes no íntron 1 e éxon 1 do gene do REα (HaeIII e MspI). Resultados: O polimorfi smo HaeIII foi encontrado em 43 (37,4%) das 115 mulheres, ao passo que o MspI estava presente em 96 (83,5%) das mesmas. Houve alto grau de concordância entre os três observadores na determinação da densidade mamográfi ca. Trinta e quatro (29,6%) mulheres tinham mamas densas, e 81 (70,4%), mamas lipossubstituídas. Conclusão: Não houve associação entre o polimorfi smo HaeIII do gene para o receptor de estrogênio alfa e densidade mamográfi ca (Fisher = 0,712). Houve associação próxima à signifi cância estatística entre o polimorfi smo MspI e densidade (Fisher = 0,098). Idade, paridade e índice de massa corporal mostraram-se associados com densidade mamográfi ca. PALAVRAS-CHAVE:Receptores estrogênicos; Polimorfi smo genético; Mamografi a; Neoplasias mamárias; Pós menopausa ABSTRACT Purpose: To assess the presence of estrogen receptor gene polymorphisms HaeIII and MspI as well as clinical factors, and their possible associations with high mammographic density in post-menopausal women. Methods: One hundred and fi fteen post-menopausal women, not in use of hormonal therapy and without clinical or mammographic lesions were evaluated. Three independent observers have determined the mammographic density pattern based on the ACR-BIRADS ® 2003 (two subjective and one objective evaluations -Adobe Photoshop 7.0 software). Oral swabs (Cytobrush) were obtained to extract DNA and the polymerase chain reaction -restriction fragment length polymorphism) was performed to assess the presence of polymorphisms in intron 1 and exon 1 from estrogen receptor gene (HaeIII and MspI). Results: The HaeIII polymorphism was found in 43 (37.4%) of the 115 women, while MspI was found in 96 (83.5%) of them. There was a good agreement among determinations of the three observers with regard to mammographic density. Thirty-four (29.6%) women had dense breasts and eighty-one (70.4%) had non-dense breasts. Conclusion: The estrogen receptor gene polymorphism Haelll showed no association with mammographic density (Fisher = 0.712), while the association between estrogen receptor gene polymorphism Mspl and mammographic density was near signifi cance (Fisher = 0.098)...

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Analysis of parenchymal density on mammograms in 1353 women 25-79 years old.

Cited by 241 publications

References 0 publications

Mammography screening in African American women

Mammography screening in African American women

Comparison of Mammography in Combination with Breast Ultrasonography Versus Mammography Alone for Breast Cancer Screening in Asymptomatic Women

Associação entre os polimorfismos HaeIII e MspI do gene para o receptor alfa de estrogênio e densidade mamográfica em mulheres após a menopausa

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