Analysis of pharmaceuticals by microemulsion electrokinetic chromatography in a suppressed electroosmotic flow environment

Pedersen‐Bjergaard, Stig; Halvorsen, Trine Grønhaug

doi:10.1007/bf02789757

Cited by 29 publications

(19 citation statements)

References 25 publications

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“…Porpan 2-ol (20% w/w) was added to improve resolution and solubility of the fat-soluble vitamins. Similar low-pH conditions were used [12] to analyse a range of pharmaceuticals.…”

Section: Effect Of Phmentioning

confidence: 99%

Background and operating parameters in microemulsion electrokinetic chromatography

2003

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Microemulsion electrokinetic chromatography (MEEKC) is an electrodriven separation technique. Separations are generally achieved using microemulsions consisting of surfactant-coated nanometer-sized oil droplets suspended in aqueous buffer. A cosurfactant such as a short-chain alcohol is generally used to stabilize the microemulsion. This review summarizes the various microemulsion types and compositions that have been used in MEEKC. The effects of key-operating variables such as surfactant type and concentration, cosurfactant type and concentration, buffer pH and type, oil type and concentration, use of organic solvent and cyclodextrin additions, and temperature are described. Specific examples of water-in-oil microemulsions and chirally selective separations are also covered.

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“…Porpan 2-ol (20% w/w) was added to improve resolution and solubility of the fat-soluble vitamins. Similar low-pH conditions were used [12] to analyse a range of pharmaceuticals.…”

Section: Effect Of Phmentioning

confidence: 99%

Background and operating parameters in microemulsion electrokinetic chromatography

2003

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“…Because at low pH there is little or no EOF generated, a negative voltage needs to be applied across the capillary in order to move the droplets through the detector, which results in the most retained compounds being detected first [31,60]. Although utilisation of a high pH buffer is most common in MEEKC, low pH buffers have been used to separate priority endocrine disrupting compounds [34], parabens from parahydroxybenzoic acid [60], a range of insoluble vitamins [61], a range of pharmaceuticals [62] and green tea catechins [46]. A negative voltage of 215 kV was applied when analysing curcuminoids in turmeric samples at a pH of 2.5 [63].…”

Section: Microemulsion Phmentioning

confidence: 98%

“…Early applications were in the separation of pharmaceutical substances such as steroids [11,34,40,48,62], cardiac glycosides [85], analgesics [52] and cephalosporins [86]. More recent applications have seen the analysis of pharmaceutical formulations.…”

Section: Pharmaceutical Analysismentioning

confidence: 99%

Recent advances in the development and application of microemulsion EKC

et al. 2007

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Microemulsion EKC (MEEKC) is an electrodriven separation technique. Separations are typically achieved using oil-in-water microemulsions, which are composed of nanometre-sized oil droplets suspended in an aqueous buffer. The droplets are stabilised by a surfactant and a cosurfactant. The novel use of water-in-oil microemulsions has also been investigated. This review summarises the advances in the development of MEEKC separations and also the different areas of application including determination of log P values, pharmaceutical applications, chiral analysis, natural products and bioanalytical separations and the use of new methods such as multiplexed MEEKC and high speed MEEKC. Recent applications (2004-2006) are tabulated for each area with microemulsion composition details.

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“…The separation of priority endocrine disrupting compounds in wastewater was performed by MEEKC at pH 2 [35]. A low pH MEEKC buffer has also been employed to separate a range of parabens from parahydroxybenzoic acid [42], a range of insoluble vitamins [43], a range of pharmaceuticals [44], and green tea catechins [27]. The separation of a parabens (parahydroxybenzoate preservatives) test-mixture at both low and high pH is shown in Fig.…”

Section: Ph Of Microemulsionmentioning

confidence: 99%

Recent advances in microemulsion electrokinetic chromatography

et al. 2004

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Microemulsion electrokinetic chromatography (MEEKC) is an electrodriven separation technique. Separations are typically achieved using oil-in-water microemulsions, which are composed of nanometre-sized droplets of oil suspended in aqueous buffer. The oil droplets are coated in surfactant molecules and the system is stabilised by the addition of a short-chain alcohol cosurfactant. The novel use of water-in-oil microemulsions for MEEKC separations has also been investigated recently. This report summarises the different microemulsion types and compositions used to-date and their applications with a focus on recent papers (2002-2004). The effects of key operating variables (pH, surfactant, cosurfactant, oil phase, buffer, additives, temperature, organic modifier) and methodology techniques are described.

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Analysis of pharmaceuticals by microemulsion electrokinetic chromatography in a suppressed electroosmotic flow environment

Cited by 29 publications

References 25 publications

Background and operating parameters in microemulsion electrokinetic chromatography

Background and operating parameters in microemulsion electrokinetic chromatography

Recent advances in the development and application of microemulsion EKC

Recent advances in microemulsion electrokinetic chromatography

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