Analysis of Related Factors of Early Mortality in Patients with Severe Renal Injury Treated with Continuous Venovenous Hemodialysis

Abstract

Background. To explore the related factors of early mortality in patients with severe renal injury treated with continuous venovenous hemodialysis (CVVHD), this study is of great significance to improve the treatment effect of hemodialysis. Methods. Clinical data of 83 patients with severe renal injury who underwent CVVHD treatment in Nephrology Department of our hospital (January 1, 2017, to June 30, 2019) were retrospectively analyzed. Results. Mortality was the highest in the first month of CVVHD treatment and then decreased obviously. Early mortality was particularly higher in patients aged 60 and above. Age of first hemodialysis, cardio cerebrovascular diseases, serum phosphorus, urea nitrogen, blood calcium, platelet count, lean body mass (LBM), and total cholesterol were significant risk factors for early mortality. Conclusion. The early mortality of patients with severe renal injury during CVVHD treatment was higher.

Establishment of a Nomogram Model for Predicting Cardiovascular and Cerebrovascular Events in Diabetic Nephropathy Patients Receiving Maintenance Hemodialysis

“…At present, maintenance hemodialysis is a major method for the treatment of DN, which plays the role of the kidneys in purifying the blood and is of great significance to patients by saving their lives [ 3 ]. However, long-term hemodialysis damages vascular endothelial function, leads to atherosclerosis and other problems, and increases the risk of cardiovascular and cerebrovascular events in patients [ 4 ]. A previous study [ 5 ] pointed out that DN patients might encounter various cardiovascular and cerebrovascular events such as heart failure, myocardial infarction, and cerebral infarction during maintenance hemodialysis, increasing the risk of death.…”

Risk prediction models for cardiovascular events in hemodialysis patients: A systematic review

“…Early identification of risk can help develop targeted strategies to limit disease progression 7 . However, the reverse epidemiological phenomenon has been observed in HD patients, whereby some traditional risk factors for CV events, such as high low‐density lipoprotein and high serum cholesterol, are not associated with shortened survival in HD patients and may even have the opposite effect 8–10 . Consequently, reliable CV event risk prediction tools used in the general population are not suitable for this specific patient group 11 .…”

“…7 However, the reverse epidemiological phenomenon has been observed in HD patients, whereby some traditional risk factors for CV events, such as high low-density lipoprotein and high serum cholesterol, are not associated with shortened survival in HD patients and may even have the opposite effect. [8][9][10] Consequently, reliable CV event risk prediction tools used in the general population are not suitable for this specific patient group. 11 In recent years, several scholars have constructed various prediction models for CV event risk in HD patients based on demographic characteristics, physical examination, HD-specific biological markers, and imaging indices.…”