Analysis of Safety for Fetus of Immunoadjuvant Influenza Vaccines in Pregnant Women

Костинов, М П; Черданцев, А. П.; Praulova, D. A.; Костинова, А. М.; POLISCHUK, V.

doi:10.24110/0031-403x-2017-96-1-91-96

Cited by 5 publications

(5 citation statements)

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“…Our study also obtained data on the activation of TLR3 expressed on granulocytes and lymphocytes after repeated administration of one dose of adjuvanted influenza vaccine (as is recommended according to present guidelines-annually) and on monocytes upon administration of two doses simultaneously and, conversely, the absence of TLR3 activation upon the first vaccination with one dose. Consequently, annual vaccination against influenza using the same adjuvanted vaccine contributes to temporary nonspecific prevention of respiratory infections [57][58][59][60][61][62][63]. Simultaneous administration of two doses of vaccines also contributes to TLR3 expression which is observed only on monocytes, and, probably, the protective effect against other respiratory infections may be less pronounced.…”

Section: Discussionmentioning

confidence: 99%

Expression of Toll-like Receptors on the Immune Cells in Patients with Common Variable Immune Deficiency after Different Schemes of Influenza Vaccination

Kostinova,

Latysheva,

Akhmatova

et al. 2023

Viruses

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Background: for the first time, the effect of one and two doses of adjuvanted influenza vaccines on toll-like receptors (TLRs) in patients with common variable immunodeficiency (CVID) was studied and compared (primary vaccination with one vs. two doses, primary vs. repeated vaccination). Materials and methods: Six patients received one dose of quadrivalent adjuvanted influenza vaccine during the 2018–2019 and 2019–2020 influenza seasons, and nine patients with CVID received two doses of trivalent inactivated influenza vaccine during 2019–2020. Expression of TLRs was measured by flow cytometry. Results: The expression of toll-like receptors in patients with CVID was noted both with repeated (annual) administration of the influenza vaccine and in most cases was accompanied by an increase in the proportion of granulocytes (TLR3 and TLR9), lymphocytes (TLR3 and TLR8), and monocytes (TLR3 and TLR9). When carried out for the first time as a simultaneous vaccination with two doses it was accompanied by an increase in the proportion of granulocytes, lymphocytes expressing TLR9, and on monocytes—TLR3 and TLR9. Conclusion: in CVID patients, the use of adjuvanted vaccines is promising, and research on the influence of the innate immunity and more effective regimens should be continued.

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Section: Discussionmentioning

confidence: 99%

Expression of Toll-like Receptors on the Immune Cells in Patients with Common Variable Immune Deficiency after Different Schemes of Influenza Vaccination

Kostinova,

Latysheva,

Akhmatova

et al. 2023

Viruses

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“…With regard to assess its impact on biochemical indicators, the cytokine profile, pregnancy hormones, fetoplacental complex, intrauterine fetal development, the state of health of newborns, physiological development of children of the first 6 months of life it was studied in accordance with the protocol of the study and is reflected in many publications. [28][29][30][31][32][33][34][35][36][37][38][39][40] In this article only the immunogenicity of the vaccine in motherchild pairs is described that is rarely found in the world publications.…”

Section: Discussionmentioning

confidence: 99%

Prospective randomized open-label comparative study of immunogenicity after subunit and polymeric subunit influenza vaccines administration among mothers and infants

Костинов¹,

Черданцев

Kuselman

et al. 2018

Human Vaccines & Immunotherapeutics

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Pregnant women are risk group for influenza infection. Results of new subunit vaccines application have not been studied enough. Prospective, randomized, open-label comparative study of subunit (Agrippal) and polymeric subunit (Grippol plus) vaccines. 42 pairs of mothers-infants were participated in the study. Protective antibodies (≥ 1:40) to different influenza strains were registered on day 1 after the birth on the same level as 53% of cases in pairs mothers-infants after immune adjuvant polymeric subunit and subunit vaccines administration. There were the same level of protective antibodies (AB) among mothers after 3 month, but transplacental antibodies decreased among infants and registered in the 13-22% cases of Grippol plus group and 31-43% cases in Agrippal S1 group. AB titre to influenza virus A/H1N1/pdm09 and A/H3N2/in pairs mothers-infants were the same in both groups in first days after birth, but AB levels to B strain were lower among infants without regard to vaccine. There is no difference in AB titres among infants of both groups at 3 month of age, but their levels were twice lower versus initial data. An immune adjuvant polymeric subunit as well as subunit vaccines application in pregnant women forms protective AB in pairs mothers-infants.

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“…По данным отчетов Европейского центра профилактики и контроля заболеваний (ECDC), введение инактивированной вакцины против гриппа беременным не вызвало увеличения неблагоприятных реакций среди матерей и новорожденных [20]. Исследования безопасности использования современных вакцин против гриппа при иммунизации беременных, проведенные в России, показали, что частота и выраженность проявлений поствакцинальных реакций после иммунизации у беременных несущественны и достоверно менее значимы, чем у женщин, находящихся в обычном физиологическом состоянии [15, [21][22][23][24][25][26][27].…”

Section: иммунизация против гриппа в период беременностиunclassified

Approach to immunoprophylaxis of infectious diseases in women during pregnancy and breastfeeding

Kostinov,

Cherdantsev,

Ozeretskovsky

et al. 2023

Infectious diseases: News, Opinions, Training

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АНАЛИТИЧЕСКИЕ ОБЗОРЫВ статье приведены фактические данные о значимости иммунопрофилактики инфекционных болезней у женщин в период беременности и грудного вскармливания. Показано положительное влияние вакцинации данного контингента женщин на показатели заболеваемости, тяжесть течения, летальных исходов от инфекционной патологии. На основании проведенного обзора литературы отечественных и зарубежных исследователей рекомендованы мероприятия по осуществлению иммунизации против наиболее актуальных инфекций, обозначены подходы к иммунопрофилактике женщин в период беременности и грудного вскармливания.Приведенные данные подтверждают, что женщины в период беременности и грудного вскармливания являются группой риска и крайне уязвимы к заражению инфекционными заболеваниями, в первую очередь возбудителями инфекций, имеющих широкое распространение на территории РФ. Авторами показано, что иммунопрофилактика инфекционных болезней является основным мероприятием по специфической защите женщин в период беременности и грудного вскармливания.Финансирование. Авторы указывают на отсутствие финансовой поддержки. Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов. Вклад авторов. Концепция -Костинов М.П.; сбор и обработка материала -Черданцев А.П.; написание текста -Озерецковский Н.А.; редактирование и оформление статьи -Никитюк Н.Ф.

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Analysis of Safety for Fetus of Immunoadjuvant Influenza Vaccines in Pregnant Women

Cited by 5 publications

References 0 publications

Expression of Toll-like Receptors on the Immune Cells in Patients with Common Variable Immune Deficiency after Different Schemes of Influenza Vaccination

Expression of Toll-like Receptors on the Immune Cells in Patients with Common Variable Immune Deficiency after Different Schemes of Influenza Vaccination

Prospective randomized open-label comparative study of immunogenicity after subunit and polymeric subunit influenza vaccines administration among mothers and infants

Approach to immunoprophylaxis of infectious diseases in women during pregnancy and breastfeeding

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