Analysis of selected recurrence risk factors after treatment of head and neck basal cell carcinoma

Szewczyk, Mateusz; Pazdrowski, Jakub; Dańczak‐Pazdrowska, Aleksandra; Golusiński, Paweł; Majchrzak, Ewa; Łuczewski, Łukasz; Marszałek, Sławomir; Silny, Wojciech; Golusiński, Wojciech

doi:10.5114/pdia.2014.40959

Cited by 24 publications

(30 citation statements)

References 28 publications

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“…The risk of recurrence of BCC after surgery is estimated at 5%–15% 11,47. In a Spanish study, the recurrence rate after surgery with histologically clear resection margins was 5% 5.…”

Section: Factors Affecting Recurrencementioning

confidence: 99%

Ocular basal cell carcinoma: a brief literature review of clinical diagnosis and treatment

Shi

Jia

2017

OTT

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Basal cell carcinoma (BCC) is a common malignant tumor throughout the world. One of the known risk factors of BCC is intense exposure to ultraviolet radiation. More than 50% of BCCs of the eyelid initially occur on the lower lid. The gold standard of diagnosis of BCC is histopathology. Treatment options for BCC consist of surgery, vismodegib, radiotherapy and imiquimod. Surgical excision using Mohs micrographic surgery or wide surgical excision with frozen section margin control is the first consideration for treatment of periocular BCC. Eyelid reconstruction should be carefully considered as both function and esthetic outcome in patients are important after clear excision of tumors. Exenteration is considered in the case of extensive orbital invasion or high-risk aggressive tumors in order to reduce the rate of recurrence.

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“…The risk of recurrence of BCC after surgery is estimated at 5%–15% 11,47. In a Spanish study, the recurrence rate after surgery with histologically clear resection margins was 5% 5.…”

Section: Factors Affecting Recurrencementioning

confidence: 99%

Ocular basal cell carcinoma: a brief literature review of clinical diagnosis and treatment

Shi

Jia

2017

OTT

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“…On average, 1 in every 10 BCCs relapses [10]. The main reason for relapse is incomplete surgical excision.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological analysis of recurrent basal cell carcinoma of the eyelid

Iljin

Zieliński

Antoszewski

et al. 2016

pdia

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Introduction Basal cell carcinoma (BCC) is the most common malignant neoplasm of the eyelids and surrounding structures, usually developing in the area of the lower lid and medial canthus. Invasive forms of BCC are connected with a high risk of recurrence, often due to incomplete excision of these lesions. Aim Clinical and pathological analysis of recurrent BCCs of the eyelids and surrounding structures. Material and methods We present clinical and pathological analysis including immunohistochemical reaction to Ki-67 antigen of 19 patients (11 women, 8 men) operated for recurrent BCCs of the eyelids in 2000–2012. Results In most cases, recurrences were present on the lower lid and in the medial canthus. In 15 patients the histopathological type did not change and in 4 cases it transformed into more invasive forms. The values of Ki-67 index for primary BCCs ranged between 1% and 20%, and for relapsing lesions between 11% and 48%. Conclusions Proper clinical and pathological evaluation to determine the risk of relapse in BCCs of the eyelids and surrounding structures should include the analysis of prognostic factors, in particular location and size, histopathological type and radicalness of surgical treatment of primary BCCs. Clinical and pathological analysis of patients with recurrent BCC of the eyelids and surrounding structures should be combined with the evaluation of proliferation index Ki-67, which is essential for prognosis and choice of the appropriate therapeutic method.

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“…It was demonstrated that chemokines have a fundamental role not only in inflammation and immune surveillance but also in cancer progression. Several malignant solid tumours have been found to be associated with marked alterations in chemokine patterns, reflecting the tumours’ biological aggressiveness, clinical progression and prognosis [1–4]. …”

Section: Introductionmentioning

confidence: 99%

“…MCP-1 and RANTES can act as growth factors, facilitate angiogenesis and promote metastasis formation. However, their functions in in-vivo cancer biology remain unclear, as available data suggest that they present with both pro- and anti-tumour properties [4, 8–11]. …”

Section: Introductionmentioning

confidence: 99%

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–2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk of basal cell carcinoma

Sobjanek¹,

Zabłotna²,

Szczerkowska-Dobosz³

et al. 2016

pdia

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IntroductionPolymorphic variants of MCP-1 and RANTES genes and their protein serum levels have been implicated in the increased risk and severity of several malignancies. However, the subject has not been explored in basal cell carcinoma (BCC) patients so far.AimTo investigate the association between monocyte chemoattractant protein 1 (MCP-1) (–2518 A/G) and RANTES (–403 G/A) polymorphism and risk and clinical course of BCC.Material and methodsThe study group consisted of 150 unrelated patients with BCC and 140 healthy, unrelated, age- and sex-matched volunteers. The polymorphisms were analysed using the amplification refractory mutation system polymerase chain reaction method (ARMS-PCR) and single specific primer-polymerase chain reaction (SSP-PCR). Serum cytokine levels were measured with ELISA.ResultsThe presence of the MCP-1 –2518 GG genotype was statistically more frequent in BCC patients and it increased the risk of BCC (OR = 2.63, p = 0.003). Genotype –330 GG was statistically more common in patients with less advanced tumours (OR = 2.8, p = 0.017). Monocyte chemoattractant protein 1 serum level was statistically higher with GG genotype. In the BCC group MCP-1 serum levels were decreased. Neither polymorphic variants of RANTES nor the chemokine serum concentration differed significantly between the study groups.ConclusionsThese findings suggest that –2518 A/G MCP-1 polymorphism may be involved in BCC pathogenesis.

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Analysis of selected recurrence risk factors after treatment of head and neck basal cell carcinoma

Cited by 24 publications

References 28 publications

Ocular basal cell carcinoma: a brief literature review of clinical diagnosis and treatment

Ocular basal cell carcinoma: a brief literature review of clinical diagnosis and treatment

Clinicopathological analysis of recurrent basal cell carcinoma of the eyelid

–2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk of basal cell carcinoma

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