Analysis of serum electrolyte and lipid profile in young Bangladeshi female with Type II Diabetes

Billah, Md. Mustahsan; Rana, S. M. Masud; Akter, N; Hossain, Mohammad Salim

doi:10.1080/23312025.2018.1431474

Cited by 3 publications

(4 citation statements)

References 44 publications

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“…Among serum electrolytes assessed, hyponatremia or low serum sodium concentration was the most prevalent abnormality in diabetic patients. 2,13,16,21,24,[26][27][28][29][30][31] The low serum concentration of sodium ion in diabetic patients may be due to osmotic diuresis induced hypovolemia. This means glucose is a substance with high osmotic activity, so its high concentration or hyperglycemia leads to increased serum osmolality that causes movement of water out of the cells and causes hypo-natremia by dilution.…”

Section: Discussionmentioning

confidence: 99%

“…20,21 Hyperglycemic hyperosmolar state is one of the acute complications of diabetes caused by inadequate fluid intake and absolute deficiency of insulin and it is characterized by hypotension, hyperosmolarity, and dehydration, and, with several weeks of polyuria, it may lead to electrolyte disorders in diabetic patients with different durations of hyperglycemia. 2,9,13,16,[22][23][24][25] Hence, this study was aimed to assess selected serum electrolyte abnormalities and factors associated with the abnormality in diabetic patients.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Selected Serum Electrolyte and Associated Risk Factors in Diabetic Patients

Woyesa¹,

Gebisa²,

Anshebo³

2020

DMSO

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The objective of this study was to assess selected serum electrolytes imbalance and associated factors in diabetic patients attending their follow up appointments in Jimma University Medical Center (JUMC) from February 1 to April 1, 2019. Patients and methods: A cross sectional study design was used to assess the selected serum electrolytes in diabetic patients attending their follow up appointments at Jimma University Medical Center (JUMC) chronic illness clinic. A convenience sampling technique was used to include 279 diabetic patients in the study and an interviewer based questionnaire was used to include all necessary data from each diabetic patient. Five milliliters of blood were collected from each subject and processed and analyzed for blood glucose and serum electrolyte determination by ABX Pentra400 and Humalyte plus 5 ion-selective electrode (ISE) system clinical chemistry analyzers. Pearson's correlation coefficient model and multivariate logistic regression were used respectively to assess the correlation and significant association between abnormal serum electrolytes and independent variables. Results: A high prevalence of one or more serum electrolyte abnormalities was determined in diabetic patients. The overall prevalence was 42.0% (n=116/276) in which hyponatremia was the highest followed by hypochloremia and hypercalcemia, 40.6%, 14.9% and 10.9% respectively. Age, type of medication, and high body mass index (BMI) had strong positive correlations with abnormal serum concentration levels of sodium (r=0.611, P=0.731), potassium (r=0.752, P=0.812) and chloride (r=0.645, P=0.459). Being employed (AOR: 3.933, 95% C.I: 1.057-14.637, P value: 0.041), treated with mixed medications (AOR: 2.9, 95% C.I: 1.292-6.441, P value: 0.010) and being unable to control blood glucose level or being hyperglycemic (AOR: 3.2, 95% C.I: 2.179-5.721, P value: 0.000) were statistically identified as risk factors for serum electrolyte abnormalities in diabetic patients. Conclusion:The serum electrolyte concentration level was highly abnormal in diabetic patients. The prevalence of abnormal concentration was more common in diabetic patients with advanced age, and some variables had strong positive correlation with abnormal serum electrolyte level in diabetic patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of Selected Serum Electrolyte and Associated Risk Factors in Diabetic Patients

Woyesa¹,

Gebisa²,

Anshebo³

2020

DMSO

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“…In diabetic conditions, increased urine output (polyuria) can occur, leading to fluid loss and subsequent disruptions in electrolyte balance. Chloride's involvement in maintaining fluid balance becomes crucial in counteracting these disruptions, as alterations in chloride levels can affect overall electrolyte equilibrium, influencing conditions related to dehydration or electrolyte imbalances often seen in diabetes (Billah et al, 2018.). The observed lack of significant alteration in chloride ion concentrations following treatment with varying doses of the A. Repens extract presents intriguing implications.…”

Section: Discussionmentioning

confidence: 99%

Effects of ethanolic extract of Aristolochia repens on biochemical and histological changes in high-fat diet and streptozotocin-induced rats

Omar,

Abubakar,

Onemola

2024

SWJ

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The study evaluated the lipid profile, electrolytes and histological changes in diabetic Wistar rats treated with stem bark extract of Aristolochia repens. Type 2 diabetes was induced in rats with high-fat diet and low dose of streptozotocin (35 mg/kg body weight). A total of thirty-five Wistar rats were fed with high-fat diet for eight (8) weeks, while five (5) Wistar rats (Sham control) were fed with low-fat diet. Non-induced male Wistar rats were treated with distilled water (Sham control); while the induced male Wistar rats were treated with distilled water, metformin (100 mg/kg), 50, 100 and 200 mg/kg ethanolic extract of Aristolonchia repens stem bark for 28 days. The rats were sacrificed; liver, kidney and serum were collected and analyzed for serum glucose, lipid profile, electrolytes and histological changes. Treatment with ethanolic extract of Aristolonchia repens stem bark significantly reduced the body weight, glucose level, total cholesterol concentration, triglycerides, low-density lipoprotein concentration and atherogenic indices. Mild pathological alterations were observed in the liver and kidney of diabetic rats at dosage above 50 mg/kg. However, the extract reduced the blood glucose, lipids and improve the selected electrolyte balance. This study suggests that ethanolic extract of stem bark of A. repens possesses antihyperglycaemia and antilipidaemic potential and might not be safe at dosage above 50 mg/kg.

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“…Although differing levels of insulin resistance in individuals of various ages and genders, as well as the direct impact of the status of hormones on the enzymes that are involved in acid-base regulation and the metabolism of lipoprotein. 18,19 Due to the occurrence of dyslipidemia among diabetic individuals, the cardiovascular risk and other morbidities substantially increased. Therefore, by effectively managing and controlling both hyperglycemia and dyslipidemia, such hazards could be decreased.…”

Section: Discussionmentioning

confidence: 99%

Lipid Profile Abnormalities among Patients with Diabetes Mellitus Type II, Presented at Tertiary Care Hospital

Memon¹,

Rani²,

Rajkumar³

et al. 2022

PJMHS

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Objective: To determine the lipid profile abnormalities among diabetes patients presented at tertiary care Hospital. Methods: This cross-sectionals study was done at medicine out patient’s department (OPD) at Muhammad Medical College Mirpur-Khas, from September 2020 to September 2021. Patients of type II diabetes mellitus, presented at medicine OPD, aged more than 40 years, diabetes duration more than three years and both genders were included. A five ml blood sample was obtained in fasting from each case and sent to the Hospital laboratory to assess the HbA1c and lipid profile. All the data was collected via a structured study proforma, and the analysis was done using SPSS version 20. RESULTS: In this study, 67 known diabetic patients were studied to observe the frequency of lipid profile abnormalities. Patient’s mean age was 51.64+10.32 years, mean BMI was 25.20+3.23 kg/m2 and mean Hba1c was 7.84+2.94%. Males were in majority 61.2% and females were 38.8%. Out of all 56.7% patients had lipid profile abnormalities. There was a positive correlation between hba1c and triglyceride level and a significant positive correlation between hba1c and total cholesterol level (r = 0.431, p = 0.001). Frequency of lipid profile abnormalities was statistically insignificant according to gender and duration of disease (p=>0.05). Conclusion: Lipid profile abnormalities were observed to be highly frequent among patients with type II diabetes mellitus. The early identification and treatment of dyslipidemia in individuals with DM seems to be a significant aspect of lowering the risk of DM-related morbidity and mortality. Keywords: Diabetes type II, lipid profile, Hba1c

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Analysis of serum electrolyte and lipid profile in young Bangladeshi female with Type II Diabetes

Cited by 3 publications

References 44 publications

<p>Assessment of Selected Serum Electrolyte and Associated Risk Factors in Diabetic Patients</p>

<p>Assessment of Selected Serum Electrolyte and Associated Risk Factors in Diabetic Patients</p>

Effects of ethanolic extract of <i>Aristolochia repens</i> on biochemical and histological changes in high-fat diet and streptozotocin-induced rats

Lipid Profile Abnormalities among Patients with Diabetes Mellitus Type II, Presented at Tertiary Care Hospital

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