Analysis of skin patch test results and metalloproteinase-2 levels in a patient with contact dermatitis

Wojciechowska, Milena; Czajkowski, Rafał; Kowaliszyn, Bogna; Żbikowska-Gotz, Magdalena; Bartuzi, Zbigniew

doi:10.5114/pdia.2014.40979

Cited by 10 publications

(8 citation statements)

References 21 publications

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“…Dermatitis due to contact with nickel was initially described among workers in the nickel-plating industry and was documented as an allergic response in 1925 ( 12 ). Frequency on nickel allergy is reported to be continuously increasing in several countries, and represents a major health and socioeconomic problem ( 13 ). In our study, 99 (27.8%) patients showed an allergic response to nickel, making it the most prevalent of the allergens identified in this study.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Epicutaneous Patch Test Results in Patients with Contact Dermatitis

Kasumagić-Halilovic

Ovčina-Kurtović

2018

Med Arch

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Background:Allergic contact dermatitis (ACD) is a delayed type of hypersensitivity from contact with a specific allergen to which the patients has developed a specific sensitivity. The aim of the study was to evaluate the results of epicutaneous patch testing with standard series of contact allergen in patients suspected to have ACD.Methods:355 cases of ACD were included in the study. Test substances were applied on the upper part of the patient’s back, on clinically uninvolved and untreated skin. All patients were free from therapy with oral antihistamines, steroids and immunosuppressants. The patch test was removed and reaction were evaluated after 48 h and 72 h. Grading of negative (-) to positive (+ to ++++) patch test was done according to the International Contact Dermatitis Research Group. Statistical data analysis was performed by using χ2–test.Results:Of the 355 cases, 146 patients were male (41.1%) and 209 were female (58.9%). The youngest patients in the study was 16 years of age and the oldest was 67 years of age. The commonest age group affected was 41-50 years. Hands were the most common site of involvement. The occupational character of skin lesions was find in 75 (21.1%). The most common positive reactions were recorded to nickel sulphate 99 (27.8%), cobalt chloride 46 (12.9%), thimerosal 31 (8.7%), colophony 23 (6.5%), carba mix 21 (5.9%), potassium dichromate 20 (5.6%), acid chromici 19 (5.3%), fragrance mix 18 (5%), balsam of Peru 13 (3.7%), formaldehyde 9 (2.5%), and other allergens 26 (7.3%). Females were significantly more likely to show a positive response to two or more allergens (p<0.05). There was no statistically significant impact of age, occupation and duration of disease on results of patch testing (p>0.05).Conclusions:Our results indicate that nickel sulphate, cobalt chloride and thimerosal are the most common allergens responsible for induction of ACD. These findings are crucial in the treatment, long term management, an education of patients with ACD.

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Section: Discussionmentioning

confidence: 99%

Analysis of Epicutaneous Patch Test Results in Patients with Contact Dermatitis

Kasumagić-Halilovic

Ovčina-Kurtović

2018

Med Arch

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“…The result on skin usually occurs by the effect of acids, bases, detergents, soaps, and topical medicinal products. 5 …”

Section: Introductionmentioning

confidence: 99%

Contact dermatitis: Clinical practice findings from a single tertiary referral hospital, a 4-Year retrospective study

Mejía

Soto-Rodríguez

Pino-García

et al. 2020

World Allergy Organization Journal

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Background It is estimated that 20% of the general population is sensitized to some kind of contact allergen. Contact dermatitis is one of the major occupational diseases worldwide. This disease has a higher prevalence in the female gender and is more frequently observed in the third or fourth decade of life. The main objective of this study was to describe the main sociodemographic and clinical characteristics of patients with contact dermatitis treated in the Allergy Unit of the San Juan De Dios Hospital – Caja Costarricense de Seguro Social. Methods Clinical records of contact dermatitis outpatients from a single hospital were analyzed, in a 4-year retrospective observational study. Results At the time of the patch testing, patients showed a mean age of 42.2 years. Disease frequency was higher in the female population (female/male ratio of 4.2:1) and in patients mostly dedicated to household workchores. Most patients presented several years of disease history, and the hands were the highest affected body part. Patch testing revealed that nickel sulfate, Cl+Me-Isothiazolinone (Kathon CG), and thimerosal were allergens regularly associated with contact dermatitis in the analyzed population. Conclusions To a great extent, sociodemographic and clinical characteristics identified in these patients resemble what is reported in other regions, including the Americas and worldwide. It is worth highlighting a high female proportion rate probably related to cultural aspects, a smaller percentage of irritant contact dermatitis that may be associated to institutional patient management, and a slight difference in the most common allergens when compared to other published studies.

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“…Nickel is the most common identified allergen worldwide, and is extensively used in everyday life. Frequency of nickel allergy is reported to be continuously increasing in several countries, and represents a major health and socioeconomic problem [ 5 ]. Hypersensitivity to nickel is found in 13% of adults and 8% of children [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Allergic contact dermatitis pattern in Kuwait: nickel leads the pack. In-depth analysis of nickel allergy based on the results from a large prospective patch test series report

Al-Mutairi

Almutawa

2017

pdia

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A b s t r a c tIntroduction: Contact dermatitis is a relatively common dermatosis reported among several population groups from all around the globe. However, the data from Kuwait is unavailable. Patch tests are essential for the diagnosis of contact sensitization. Aim: To determine a relative frequency and pattern of sensitizers to different allergens in patients of suspected contact dermatitis in Kuwait and, also to study the role of the commonest sensitizer in detail. Material and methods: Patch tests were performed in 2461 consecutive patients with a clinical diagnosis of contact dermatitis seen at our hospital between September 1, 2014 and August 31, 2015. Out of the total of 1381 (56.1%) patients with positive patch test results to at least one allergen, 546 (22.2%) patients with a single positive reaction to nickel only (single largest sensitizer) were selected as the study population for further detailed analysis. Results: At least one positive patch test reaction was found in 1381 (56.12%) patients. Nickel was found to be the most common sensitizer seen in 546 (40%) patients. The mean age was 37.3 ±13.8 years and the mean duration of disease was 27.3 ±13.8 months. Most (387/546) patients sensitized were females. The forearms/hands and wrists were the most prevalent sites (52.56% of the participants). In 58.91% of women, dermatitis was more often confined to other sites, mostly ears and the neck due to earrings and necklaces. Just more than half of the number (51.09%) of nickel allergic patients were found in the age group of 15-25 years. Hairdressers/beauticians were the most affected group followed by house workers (housewives, cleaners, housekeepers). Conclusions: Nickel is the single most common sensitizer found in our patients, and female sex, young age, occupation with long hours of contact to nickel are high risk factors. We recommend that a directive, which limits the release of nickel from products with extended skin contact, be approved in Kuwait.

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Analysis of skin patch test results and metalloproteinase-2 levels in a patient with contact dermatitis

Cited by 10 publications

References 21 publications

Analysis of Epicutaneous Patch Test Results in Patients with Contact Dermatitis

Analysis of Epicutaneous Patch Test Results in Patients with Contact Dermatitis

Contact dermatitis: Clinical practice findings from a single tertiary referral hospital, a 4-Year retrospective study

Allergic contact dermatitis pattern in Kuwait: nickel leads the pack. In-depth analysis of nickel allergy based on the results from a large prospective patch test series report

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