Analysis of skin testing and serum‐specific immunoglobulin E to predict airway reactivity to cat allergens

Fernández, Carmen Jiménez; Cárdenas, Remedios; Martín, David Rentero; Garcimartin, Maria Isabel; Romero, Sherezade Moñino; Cámara, Agustı́n Gómez de la; Vives, R.

doi:10.1111/j.1365-2222.2007.02659.x

Cited by 26 publications

(27 citation statements)

References 26 publications

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“…In children, a wheal size of ≥4.5 mm showed a sensitivity of 75% and a specificity of 86% to predict an EAR (AUC 0.85) . In adults, a positive SPT (wheal size 3 mm) failed to discriminate between challenge‐positive and challenge‐negative patients . In HDM allergies, the skin sensitivity did not significantly contribute to the prediction of an EAR .…”

Section: Discussionmentioning

confidence: 93%

“…Even in patients who are allergic to cats, the predictive value of the clinical history to detect cat allergy was low . Possible reasons for the modest degree of accuracy might include multiple sensitizations and the occurrence of several different allergens together . Allergen challenges allow for the demonstration of both the presence of allergen‐specific IgE and the causal role of the allergen .…”

mentioning

confidence: 99%

“…In bronchial allergen challenges, attempts have been made to predict the early or late asthmatic response (EAR, LAR). Bronchial hyperresponsiveness (BHR) to metchacholine, the wheal size in SPT, the allergen‐specific IgE, the baseline PFT and sputum eosinophils have been shown to correlate with and predict asthmatic reactions in adults . In children, the wheal size in the SPT, allergen‐specific and total IgE, as well as clinical signs of atopic diseases, were the strongest predictors of response to allergen challenge .…”

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confidence: 99%

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Bronchial allergen challenges in children – safety and predictors

Schulze

Reinmüller

Herrmann

et al. 2013

Pediatric Allergy Immunology

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Section: Discussionmentioning

confidence: 93%

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confidence: 99%

mentioning

confidence: 99%

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Bronchial allergen challenges in children – safety and predictors

Schulze

Reinmüller

Herrmann

et al. 2013

Pediatric Allergy Immunology

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“…The IDT results of 62 allergen extracts on 3,335 patients in a three-year period (2001–2003) are shown in Figure 1 (children less than three years old were excluded). In our department, IDT has always been exhibited to be effective and safe and was reported to be diagnostically better than the skin prick test [8]. Nevertheless, informed consent for testing was obtained from all patients or their guardians, and the current study was approved by the Ethics Committee of the Second Affiliated Hospital of Guangzhou Medical University.…”

Section: Methodsmentioning

confidence: 99%

Reduction of the Number of Major Representative Allergens: From Clinical Testing to 3-Dimensional Structures

Liu

Huang

et al. 2014

Mediators of Inflammation

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Vast amounts of allergen sequence data have been accumulated, thus complicating the identification of specific allergenic proteins when performing diagnostic allergy tests and immunotherapy. This study aims to rank the importance/potency of the allergens so as to logically reduce the number of allergens and/or allergenic sources. Meta-analysis of 62 allergenic sources used for intradermal testing on 3,335 allergic patients demonstrated that in southern China, mite, sesame, spiny amaranth, Pseudomonas aeruginosa, and house dust account for 88.0% to 100% of the observed positive reactions to the 62 types of allergenic sources tested. The Kolmogorov-Smironov Test results of the website-obtained allergen data and allergen family featured peptides suggested that allergen research in laboratories worldwide has been conducted in parallel on many of the same species. The major allergens were reduced to 21 representative allergens, which were further divided into seven structural classes, each of which contains similar structural components. This study therefore has condensed numerous allergenic sources and major allergens into fewer major representative ones, thus allowing for the use of a smaller number of allergens when conducting comprehensive allergen testing and immunotherapy treatments.

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“…We hypothesized that perennial allergic conjunctivitis might be mediated by specific IgG antibodies associated with indoor allergens. Although allergens derived from cats are a major cause of indoor allergen-induced allergic disease [10], the relation between cat allergens and allergic conjunctivitis has not been described previously. Accordingly, the aims of the present study were (1) to compare sensitization to cat allergens among healthy subjects and patients with seasonal or perennial allergic conjunctivitis, (2) to compare the levels of specific IgG and IgE antibodies for cat allergens with cutaneous reactivity to cat allergens in patients who had perennial allergic conjunctivitis, and (3) to evaluate the relation between serum levels of specific IgG for cat allergens and the features of perennial allergic conjunctivitis.…”

Section: Introductionmentioning

confidence: 99%

Specific IgG for cat allergens in patients with allergic conjunctivitis

et al. 2014

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Immunoglobulin G (IgG) antibodies are involved in type II and type III hypersensitivity. We evaluated the relation between perennial allergic conjunctivitis and serum levels of specific IgG for cat allergens. A prospective study was conducted in patients with seasonal allergic conjunctivitis (seasonal group, n = 10), patients with perennial allergic conjunctivitis (perennial group, n = 10), and healthy control subjects (control group, n = 10). Serum levels of specific IgE and IgG for cat allergens and total tear IgE were measured, and a skin prick test was also performed. In addition, a severity score associated with allergic conjunctivitis was calculated (0-30). The positive rates and scores of for total tear IgE, serum cat-specific IgE, and serum cat-specific IgG were all higher in the seasonal and perennial groups than in the control group (all p < 0.05). Serum cat-specific IgG levels were higher in the perennial group than in the seasonal group (p = 0.0156), but there was no significant difference in the grade of cat-specific IgE between the two groups (p = 0.3008). On multivariate analysis, the mean wheal diameter for cat allergen was associated with the serum level of cat-specific IgG (not IgE) in all patients [odds ratio (OR) = 31.979, p < 0.0001]. Multivariate analysis revealed that the total objective score was strongly associated with serum cat-specific IgG (OR = 23.015, p < 0.0001). These findings suggest that specific IgG antibodies may be involved in perennial allergic symptoms caused by indoor allergens such as cat allergens.

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Analysis of skin testing and serum‐specific immunoglobulin E to predict airway reactivity to cat allergens

Abstract: Levels of serum-specific IgE to cat allergens and intradermal ST can be used to diagnose and treat more accurately asthmatic patients sensitized to cat epithelium when there is uncertainty about cat epithelium causality.

Cited by 26 publications

References 26 publications

Bronchial allergen challenges in children – safety and predictors

Bronchial allergen challenges in children – safety and predictors

Reduction of the Number of Major Representative Allergens: From Clinical Testing to 3-Dimensional Structures

Specific IgG for cat allergens in patients with allergic conjunctivitis

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