Analysis of the central zone of the retina in patients with diabetic macular edema

Бикбов, М.М.; Мухтарамович, Бикбов Мухаррам; Fayzrakhmanov, R. R.; Рустамович, Файзрахманов Ринат; Yarmuhametova, Alia Linarovna; Линаровна, Ярмухаметова Алия; Зайнуллин, Р.М.; Мухаметович, Зайнуллин Ринат

doi:10.14341/dm7126

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…Вместе с тем за последние десять лет отмечается экспоненциальный рост общего объема операций, проводимых на макулярной зоне [1]. Очевидно, что добиться высоких функциональных результатов, даже при успешном проведении операции, удается далеко не во всех случаях, что требует поиска новых методик и оптимизации хирургического лечения [2]. Высокоточное диагностическое оборудование позволяет сделать выбор в пользу той или иной техники операции.…”

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“…Высокоточное диагностическое оборудование позволяет сделать выбор в пользу той или иной техники операции. В последние годы появились оптические когерентные томографы (ОКТ) широкого разрешения, позволяющие визуализировать структуры сетчатки до 2-3 мкм [2][3][4]. Достоверно оценить работоспособность фоторецепторов позволяет метод микропериметрии -определение световой чувствительности сетчатки в заданной зоне исследования [3,5].…”

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“…Достоверно оценить работоспособность фоторецепторов позволяет метод микропериметрии -определение световой чувствительности сетчатки в заданной зоне исследования [3,5]. В структуре мембраны были выделены различные клеточные элементы: миофибробласты, глиальные клетки и клетки пигментного эпителия [2,4]. Их появление характеризуется реакцией на различные нарушения в архитектонике сетчатки.…”

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Сomparative Analysis of the Long-Term Results of Diabetic Macular Edema and Epiretinal Membrane Surgical Treatment

et al. 2019

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The purpose of the study — to conduct a comparative analysis of structural and functional indicators of the central zone of the retina in patients with diabetic macular edema and epiretinal membrane in the remote period after surgical treatment. Patients and Methods. We examined 97 patients with diabetic macular edema in combination with the epiretinal membrane aged 53 to 68 years (mean age 61 ± 5.4 years). All patients underwent vitrectomy with an internal limiting membrane peeling (ILM). Patients were divided into 3 groups depending on the intravitreal use of an angiogenesis inhibitor. The analysis of the remote anatomical and functional results of patients of different groups during 1 year of observation was carried out. Results. In patients after treatment using the proposed technique, the central retinal thickness was reduced by 16.19 % (p = 0.031) compared with monotherapy and by 11.51 % (p = 0.039) compared with a phased treatment method. Visual acuity significantly increased in the treatment group by the single-step method by 1.53 times (p = 0.024) compared with the group where only vitrectomy was performed, and also 1.44 times (p = 0.029) compared with the delayed administration of angiogenesis inhibitor in avital eye. Patients in all groups have showed an improvement in central photosensitivity 1 month after surgery, followed by a slight decrease in performance. However, by 12 months, the level of central photosensitivity in group 2 was significantly higher than in other groups (p < 0.05). A comparative analysis of the spatial distribution of macular pigment has showed that, along with the development of the pathological process, macular pigments were dispersed in the retinal tissue. On the background of treatment, their concentration was normalized in the central zone of the retina, without increasing the quantitative composition. Conclusion Analysis of the morphofunctional parameters of the retina central section in patients with diabetic macular edema and epiretinal membrane in the dynamics of treatment with various techniques led to the creation of an algorithm for managing patients. It allows to achieve high clinical and functional results in an overwhelming percentage of cases and, thereby, significantly improve medical and social rehabilitation, and also the quality of life of this contingent.

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Сomparative Analysis of the Long-Term Results of Diabetic Macular Edema and Epiretinal Membrane Surgical Treatment

et al. 2019

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Determination of the optical density of macular pigment: clinical value

Бикбов

Usubov

Zaynullina

et al. 2022

Rossijskij oftalʹmologičeskij žurnal

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The density of macular pigment in the central retina is the total concentration of lutein, zeaxanthin and meso-zeaxanthin. Normally, the average value of the optical density of macular pigment can vary significantly as it depends on the person's lifestyle, the total amount of pigment in the body, nutrition, gender, age, as well as concomitant diseases such as diabetes, obesity, arterial hypertension. Differences in the level of optical density of macular pigment between different countries were revealed and it was showed that this parameter drops in cases of retinal pathology, cataract, glaucoma, myopia, macular degeneration, or diabetic macular edema. The level of macular pigment may be considered as a significant diagnostic criterion in many ophthalmic pathologies, so any changes of this parameter require attentive consideration.

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Macular Pigment Optical Density as a Measurable Modifiable Clinical Biomarker

Masri,

Armanazi,

Inouye

et al. 2024

Nutrients

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Background: Carotenoids are present throughout retina and body its dense deposition leads to an identifiable yellow spot in the macula. Macular pigment optical density (MPOD) measured in the macula is vital to macular well-being and high-resolution visual acuity. MPOD has also been associated with various health and disease states. We sought to review the literature on this topic and summarize MPODs role as a measurable modifiable clinical biomarker, particularly as a measure of the eye’s antioxidant capacity in the context of oxidative damage and retinal ischemia. Methods: A literature review collated the articles relevant to MPOD, carotenoid intake or supplementation, and their influence on various health and disease states. Results: Literature reveals that MPOD can serve as a reliable biomarker for assessing the retinal defense mechanisms against oxidative stress and the deleterious effects of excessive light exposure. Elevated MPOD levels offer robust protection against the onset and progression of age-related macular degeneration (AMD), a prevalent cause of vision impairment among the elderly population. MPOD’s implications in diverse ocular conditions, including diabetic retinopathy and glaucoma, have been explored, underscoring the real need for clinical measurement of MPOD. The integration of MPOD measurement into routine eye examinations presents an unparalleled opportunity for early disease detection, precise treatment planning, and longitudinal disease monitoring. Conclusions: Longitudinal investigations underscore the significance of MPOD in the context of age-related ocular diseases. These studies show promise and elucidate the dynamic nuances of MPOD’s status and importance as a measurable, modifiable clinical biomarker.

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Analysis of the central zone of the retina in patients with diabetic macular edema

Cited by 3 publications

References 8 publications

Сomparative Analysis of the Long-Term Results of Diabetic Macular Edema and Epiretinal Membrane Surgical Treatment

Сomparative Analysis of the Long-Term Results of Diabetic Macular Edema and Epiretinal Membrane Surgical Treatment

Determination of the optical density of macular pigment: clinical value

Macular Pigment Optical Density as a Measurable Modifiable Clinical Biomarker

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