Analysis of the clinical value of 18F-FDG PET/CT in hepatic alveolar echinococcosis before and after autologous liver transplantation

Qin, Yongde; Li, Xiaohong; Zhang, Qizhou; Xie, Bingteng; Ji, Xuewu; Li, Yubin; Yiblayan, Amina; Wen, Hao

doi:10.3892/etm.2015.2857

Cited by 15 publications

(8 citation statements)

References 16 publications

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“…The treatment of the advanced HAE, especially the necessity of aggressive operations, is disputed. [15][16][17] In the retrospective study, we analyzed 42 patients with advanced HAE treated with palliative resection, palliative nonresective procedures, OLT, or albendazole therapy alone. These patients were not randomized and that treatments were based on disease presentations, individual wishes, and physician choices as well.…”

Section: Discussionmentioning

confidence: 99%

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Management of Advanced Hepatic Alveolar Echinococcosis: Report of 42 Cases

Qu¹,

Guo²,

Sheng³

et al. 2017

The American Society of Tropical Medicine and Hygiene

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Abstract. Radical resection is the first choice for hepatic alveolar echinococcosis (HAE). However, many patients with advanced HAE have no chance to be treated with curative resection owing to the long clinical latency. This study aimed to evaluate the necessity of aggressive operations, like palliative resection and orthotopic liver transplantation (OLT), in the management of advanced HAE. A retrospective study analyzed 42 patients with advanced HAE treated with palliative resection (N = 15), palliative nonresective procedures (N = 13), OLT (N = 3), or albendazole therapy alone (N = 11). The patients' condition before treatments was comparable among all the four groups. The overall 1-year, 3-year, and 5-year survival rates of the 42 cases were 81.0%, 45.2%, and 23.8%, respectively. No event occurred to end the follow-up during the 5-year observation period except death. The survival time (median ± standard error) of the palliative resection group (3.6 ± 1.4 years) was longer than that of the palliative nonresective procedures group (1.5 ± 0.2) and the albendazole therapy-alone group (1.0 ± 0.4). The 5-year survival rates after palliative resection and liver transplantation were 40.0% and 66.7%, compared with only 7.7% and 9.1% after palliative nonresective procedures or albendazole therapy alone. Therefore, we concluded that aggressive treatment with a multimodality strategy could contribute to prolonged survival in patients with advanced HAE. Moreover, the prognosis of the patients who received albendazole therapy alone or palliative nonresective procedures is poor.

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Section: Discussionmentioning

confidence: 99%

“…The management of advanced HAE, especially the necessity of aggressive operations, like palliative resection and orthotopic liver transplantation (OLT), remains controversial. [15][16][17] …”

Section: Introductionmentioning

confidence: 99%

Management of Advanced Hepatic Alveolar Echinococcosis: Report of 42 Cases

Qu¹,

Guo²,

Sheng³

et al. 2017

The American Society of Tropical Medicine and Hygiene

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“…18 F-FDG PET/CT demonstrates metabolic activity and so can effectively determine the biological boundary of liver AE along with the metabolic activity of surviving liver following autologous liver transplantation [77] and is, therefore, recommended for the initial assessment and follow-up of human AE [78]. In a recent study, CEUS and 18 F-FDG PET showed good inter-rater reliability in determining the activity of hepatic AE [60].…”

Section: Positron Emission Tomography (Pet)mentioning

confidence: 99%

Cystic and alveolar echinococcosis of the hepatobiliary tract – the role of new imaging techniques for improved diagnosis

Dietrich

Douira-Khomsi²,

Gharbi³

et al. 2020

Med Ultrason

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Cystic echinococcosis (CE) or hydatidosis (hydatid cysts) is an infection with a wide spectrum of manifestations, from symptomatic infection to fatal disease. Ultrasound (US) allows screening, diagnosis, differential diagnosis, treatment guidance and follow-up of CE under many circumstances. Hydatid cysts are predominantly observed in the liver. Herewith we present a review to demonstrate established and innovative imaging features of CE of the hepatobiliary tract.

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“…Then, the CT data were applied to perform attenuation corrections for the PET images. The ordered subset expectation maximization iterative method was used to reconstruct the images of the cross-sectional, coronal and sagittal planes, as well as the PET/CT fusion images [10].…”

Section: F-fdg-pet/ct and Tbrsmentioning

confidence: 99%

Quantitative evaluation of range and metabolic activity of hepatic alveolar echinococcosis lesion microenvironment using PET/CT and multi-site sampling method

Aini

Yimingjiang

Yasen

et al. 2020

Preprint

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Background: Alveolar echinococcosis (AE) lesion microenvironment (LME) is crucial site where parasite-host interactions happen and of great significance during surgery and obtaining liver samples for basic research targeting immunology. However, little is known about quantification of LME range and its’ metabolic activity regarding different lesion types.Methods: A prospective analysis of LME from consecutive surgical AE cases with relevant imaging results was performed. Patients (n=39) received abdominal computed tomography (CT) and position emission tomography/computed tomography using 18F-fluodeoxyglucose (18F-FDG-PET/CT) within one week prior to surgery. Tumor to background ratios (TBRs) of standard uptake value (SUV) in PET/CT was calculated for corresponding LME regions. Multi-site sampling method (MSS, n=26) was introduced to obtain histological slides from LME at different levels off the lesion to evaluate immune cell infiltrative ranges quantitatively. At last, data was statistically analyzed from the perspective of different lesion types.Results: Altogether six major lesion categories have been identified based on different morphology and calcification pattern (A: non-calcified uniform density lesion; B: diffuse calcified solid lesion; C: half necrotic and half solid lesion with minor calcification; D: half necrotic and half solid lesion with obvious calcification; E: subtotal necrotic lesion with minor calcification; F: total necrotic lesion with obvious calcification). Statistical significances were resulted from TBRs calculation (A>B, A>D, A>F, B<C, B<E, A+C+E>B+D+F, etc.). Less calcified lesions were evidenced with higher TBRs, however, not much was valuable for necrosis. The 95% CI of LME ranges were (10.0, 12.1) mm and (9.9, 14.0) mm by PET/CT and MSS. And, weak regressions between TBRs and LME ranges indicated by PET/CT or MSS (r2 respectively were 0.2436 and 0.3171) were observed.Conclusions: PET/CT showed distinct TBRs for different lesion types with heterogenic calcification. PET/CT and MSS had similar discoverability for LME ranges, which also varied among different lesion types. Higher activity meant wider LME range within certain limit. This pioneering study would be able to provide references for both surgical removal of lesions and sample acquisitions more accurately for basic research targeted to immunology.

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Analysis of the clinical value of 18F-FDG PET/CT in hepatic alveolar echinococcosis before and after autologous liver transplantation

Cited by 15 publications

References 16 publications

Management of Advanced Hepatic Alveolar Echinococcosis: Report of 42 Cases

Management of Advanced Hepatic Alveolar Echinococcosis: Report of 42 Cases

Cystic and alveolar echinococcosis of the hepatobiliary tract – the role of new imaging techniques for improved diagnosis

Quantitative evaluation of range and metabolic activity of hepatic alveolar echinococcosis lesion microenvironment using PET/CT and multi-site sampling method

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