Analysis of the Effectiveness for Death Prevention of Patients Included in a Sepsis Protocol

Abstract

Sepsis is a systemic proinflammatory response caused by bacterial, fungal, viral, autoimmune diseases causing dysfunction of one or more organs or systems. In this context, the aim of this study was to compile the literature on the impact of implementing the sepsis protocol on lower mortality and morbidity, to elucidate risk factors and possible interventions. A total of 55 studies were identified according to our search strategy. After applying the adopted inclusion and exclusion criteria, a total of 31 studies in Medline/Pubmed and Medline/BVS were excluded. Then the titles, abstracts and the full text were read, 20 of the 24 references were excluded based on the eligibility criteria. Thus, 4 references were selected for full text evaluation. Finally, four articles were eligible for qualitative evaluation. Despite the early institution of therapeutic measures advocated in the international literature, mortality from sepsis in the institution in question is still high. All references demonstrate the association of better prognosis for early diagnosis of sepsis with respect to protocol adoption, with P-value lower than the significance level = 0.05. This review corroborates that there are still gaps in the treatment of sepsis. However, the implementation of this protocol allows for a better diagnosis of sepsis, reduces possible early sepsis diagnoses, and promotes the effective use of antimicrobial agents in this population. Therefore, we need to investigate more closely the associated risk factors and the implementation of sepsis protocols to obtain a possible effective intervention.