Analysis of the expression levels of chemerin, ox‐LDL, MMP‐9, and PAPP‐A in ICVD patients and their relationship with the severity of neurological impairment

Abstract

Objective The study aimed to analyze the relationship between expression levels of chemerin, oxidized low density lipoprotein (ox‐LDL), matrix metalloproteinase 9 (MMP‐9) and pregnancy associated plasma protein A (PAPP‐A) in ischemic cerebrovascular disease (ICVD) patients and the relationship between the mentioned indicators and the degree of neurological impairment. Methods From January 2020 to February 2021, a total of 328 cases of ICVD patients were admitted to our hospital, and 240 cases of healthy people (control group) were prospectively recruited into this study. The 328 patients were divided into 2 ischemic subtypes, with 233 cases as acute cerebral infarction (ACI) and 95 cases as transient ischemic attack (TIA). Laboratory tests were compared among the groups. Spearman rank correlation was used to analyze the correlation between chemerin, ox‐LDL, MMP‐9, PAPP‐A levels and neurological deficit. Unconditional logisitic regression was used to analyze the risk factors for neurological deficits. Results The high density lipoprotein cholesterol (HDL‐C), fasting plasma glucose (FPG), chemerin, ox‐LDL, MMP‐9, and PPAP‐A levels in the ACI group were significantly higher than those in the TIA group and control group ( p < 0.05, respectively), while the levels of the mentioned indicators in the TIA group were significantly higher than those in control group ( p < 0.05, respectively). The levels of the given indicators decreased successively in the severe, moderate, and mild neurological deficits population and control group, with statistical difference. Spearman rank correlation analysis showed that chemerin, ox‐LDL, MMP‐9, and PPAP‐A levels were positively correlated with the degree of neurological deficit in ICVD patients. Unconditional logistic regression analysis showed that chemerin, ox‐LDL, MMP‐9, and PPAP‐A were the independent risk factors for neurological deficit in patients with ICVD. Conclusion LDL‐C, FPG, chemerin, ox‐LDL, MMP‐9, and PPAP‐A were highly expressed in ACI and neurological deficit patients. Chemerin, ox‐LDL, MMP‐9, and PPAP‐A may be the independent risk factors for neurological deficit in patients with ICVD.

Role of Chemerin in Cardiovascular Diseases

“…Interestingly, some authors state that chemerin participates in pre-eclampsia development by CMKLR1/Akt/enhancer-binding protein-alpha (CEBPα) axis activation and angiogenesis suppression and induces M1 macrophage polarization [ 152 ]. Expression levels of chemerin, pregnancy-associated plasma protein A (PAPP-A), ox-LDL, and matrix metalloproteinase 9 were found to be independent risk factors for neurological impairment in ischemic cerebrovascular disease patients [ 153 ]. The chemerin/CMKLR1 axis promotes vascular smooth muscle cell migration and proliferation through Akt/ERK phosphorylation, causing vascular remodelling and hypertension [ 131 ] ( Table 1 ).…”