Analysis of the long noncoding RNA profiles of RD and SH-SY5Y cells infected with coxsackievirus B5, using RNA sequencing

Teng, Peiying; Yang, Heng; Li, Jing; Yang, Fan; Chen, Wei

doi:10.1007/s00705-021-05313-6

Cited by 4 publications

(4 citation statements)

References 44 publications

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“…However, the involvement of lncRNAs in the innate immune response to CVB5 infection remains largely unknown, and the mechanisms are poorly understood. In the previous study, we identified the lncRNA expression profiles in RD cells infected with CVB5 and found a novel upregulated lncRNA, LINC1392 ( Teng et al., 2022 ). In this study, we further elucidated the role of LINC1392 during CVB5 infection.…”

Section: Discussionmentioning

confidence: 99%

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Long noncoding RNA 1392 regulates MDA5 by interaction with ELAVL1 to inhibit coxsackievirus B5 infection

Teng

et al. 2023

Virologica Sinica

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Section: Discussionmentioning

confidence: 99%

“…The previous study analyzed the lncRNAs expression profiles of Rhabdomyosarcoma (RD) cells infected with CVB5 ( Teng et al., 2022 ). The current study focused on a novel cytoplasmic lncRNA, LINC1392, which was a highly inducible in RD cells during CVB5 infection.…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA 1392 regulates MDA5 by interaction with ELAVL1 to inhibit coxsackievirus B5 infection

Teng

et al. 2023

Virologica Sinica

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“…Coxsackievirus B5 (CVB5) is a major pathogen of HFMD, which has an increasing incidence in recent years. Teng et al analyzed the lncRNA profile of CVB5 infected RD and SH−SY5Y cells through RNA sequencing, and revealed the potential of lncRNA-IL12A as a biomarker ( Teng et al., 2022 ). These studies indicate that ncRNAs have significant potential for application in clinical diagnosis of HFMD.…”

Section: Potential Clinical Application Of Ncrnas In Hfmdmentioning

confidence: 99%

Role of Non-Coding RNA in Neurological Complications Associated With Enterovirus 71

Yang

Zhang

Chen

et al. 2022

Front. Cell. Infect. Microbiol.

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Enterovirus 71 (EV71) is the main pathogenic virus that causes hand, foot, and mouth disease (HFMD). Studies have reported that EV71-induced infections including aseptic meningitis, acute flaccid paralysis, and even neurogenic pulmonary edema, can progress to severe neurological complications in infants, young children, and the immunosuppressed population. However, the mechanisms through which EV71 causes neurological diseases have not been fully explored. Non-coding RNAs (ncRNAs), are RNAs that do not code for proteins, play a key role in biological processes and disease development associated with EV71. In this review, we summarized recent advances concerning the impacts of ncRNAs on neurological diseases caused by interaction between EV71 and host, revealing the potential role of ncRNAs in pathogenesis, diagnosis and treatment of EV71-induced neurological complications.

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“…In a previous study, our group revealed the expression profile of lncRNAs after CVB5 infection of RD and SHSY5Y cells, however, the function of lncRNAs in coxsackievirus infection is still under study. [ 72 ].…”

Section: Cellular Lncrna Profile In Hfmd Virus Infectionmentioning

confidence: 99%

Roles of Non-Coding RNAs in Virus-Host Interaction About Pathogenesis of Hand-Foot-Mouth Disease

Chen

et al. 2022

Curr Microbiol

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Noncoding RNAs (ncRNAs) represent the largest and main transcriptome products and play various roles in the biological activity of cells and pathological processes. Accumulating evidence shows that microRNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA) are important ncRNAs that play vital regulatory roles during viral infection. Hand-foot-mouth disease (HFMD) virus causes hand-foot-mouth disease, and is also associated with various serious complications and high mortality. However, there is currently no effective treatment. In this review, we focus on advances in the understanding of the modulatory role of ncRNAs during HFMD virus infection. Specifically, we discuss the generation, classification, and regulatory mechanisms of miRNA, lncRNA, and circRNA in the interaction between virus and host, with a particular focus on their influence with viral replication and infection. Analysis of these underlying mechanisms can help provide a foundation for the development of ncRNA-based antiviral therapies.

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Analysis of the long noncoding RNA profiles of RD and SH-SY5Y cells infected with coxsackievirus B5, using RNA sequencing

Cited by 4 publications

References 44 publications

Long noncoding RNA 1392 regulates MDA5 by interaction with ELAVL1 to inhibit coxsackievirus B5 infection

Long noncoding RNA 1392 regulates MDA5 by interaction with ELAVL1 to inhibit coxsackievirus B5 infection

Role of Non-Coding RNA in Neurological Complications Associated With Enterovirus 71

Roles of Non-Coding RNAs in Virus-Host Interaction About Pathogenesis of Hand-Foot-Mouth Disease

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