Analysis of the mortality probability of preoperative MRI features in malignant astrocytomas

Abstract

AIm:The aim of the present study is to analyze the effects of the MRI features on the recurrence time and prognosis, and to emphasize the analyses of mortality risks in malignant astrocytomas. mAterIAl and methOds:The effects of preoperative MRI features on prognosis were studied for follow-up period of 45 months, from November 1999 to August 2003, on a total of 79 patients' 41 cases of total resection and 38 cases of subtotal resection diagnosed to have malignant astrocytoma subsequent to craniotomy. results:The cases of gross total resection had 2.2 times as high survival rate as those in the subtotal resection group (p<0.01). The comparison of the cases in the groups in relation to their ages revealed that mortality rate rose 4.35 times (p<0.01) in the age group of 60 years and above, and 2.1 times in the age group of 45-59 years. When cases without necrosis were compared with the group containing necrosis of grade 1, 2, 3, it was observed that the probability of mortality increased 3.84 (p<0.01), 4.15 times (p<0.01) in the case of necrosis of grade 2 and 3, respectively by means of Cox regression model. BulGulAr: Cox regresyon analizinde; gross total rezeksiyon yapılan olguların subtotal rezeksiyon grubuna göre 2,2 kat hayatta kalma olasılığına sahip olduğu görüldü (p<0,01). Yaş gruplarında ise, 60 ve üzeri yaş grubundaki olguların ölüm olasılığının 4.4 kat arttığı (P<0.01), ölüm olasılığındaki bu artışın 45-59 yaş grubunda 2,1 kat olduğu tespit edildi. Nekroz içermeyen olgular 1, 2 ve 3. derece nekroz içeren grupla karşılaştırıldığında; 2. derece nekroz içeren grupta ölüm olasılığının 3,84 kat arttığı (P<0,01), 3. derece nekroz içeren grupta ise ölüm olasılığının 4,15 kat (p<0,01) arttığı görüldü. sOnuÇ: Malign astrositomalarda Preoperatif MRI'daki nekroz hastalığın prognozu açısından önemli bir klinik belirleyici olarak görünmektedir.

Multicenter imaging outcomes study of The Cancer Genome Atlas glioblastoma patient cohort: imaging predictors of overall and progression-free survival

“…Regarding the prognostic role of tumor necrosis, there are various results among the limited numbers of survival studies in GBM. 10,19,21,24 Hammoud et al 19 found that the amount of tumor necrosis on preoperative scans was the strongest prognostic variable. This is similar to other retrospective studies 10,24 ; however, our study showed no significant association between degree of tumor necrosis and survival.…”

“…10,19,21,24 Hammoud et al 19 found that the amount of tumor necrosis on preoperative scans was the strongest prognostic variable. This is similar to other retrospective studies 10,24 ; however, our study showed no significant association between degree of tumor necrosis and survival. This can be attributed to differences in measurement and grading system, that is, Table 3.…”

Assessing the Effects of Software Platforms on Volumetric Segmentation of Glioblastoma

“…While necrosis has also typically been implicated in survival [ 50 , 51 ], other studies have not found significant associations. For example, in a study, based in part on the patients used in the present analysis, necrosis was not found to be associated with survival.…”

Gliosarcomas: Analysis of Braga Hospital Cases and Review of the Literature

“…Gliosarcomas are rare neoplasms of the central nervous system, constituting 0.48% of intracranial tumors and 1.8-10% of glioblastomas [1][2][3][4][5][6][7][8][9]. They were first described in 1895 as brain neoplasms formed by glial and mesenchymal components and in 2000 the World Health Organization (WHO) classified them as a variant of glioblastomas.…”