Analysis of the Relationship between Helicobacter pylori Infection and Diabetic Gastroparesis

Abstract

Background:Whether Helicobacter pylori infection is associated with diabetic gastroparesis (DGP) is unclear. This study aimed to investigate the potential correlation between H. pylori infection and DGP.Methods:In this study, 163 patients with type 2 diabetes mellitus and 175 nondiabetic patients who were treated in our department were divided into DGP, simple diabetes, non-DGP (NDG), and normal groups based on their conditions. The H. pylori infection rate in each group was calculated. H. pylori eradication therapy was performed for patients with H. pylori infection in each group. The eradication rates were compared between the groups, and the improvements in gastroparesis-associated symptoms were compared before and after treatment in patients with DGP.Results:The H. pylori infection rate was 74.6% in the DGP group, which was significantly higher than that in the simple diabetes (51.1%, P < 0.01), NDG (57.7%, P < 0.05), and normal groups (48.0%, P < 0.01). With increased disease course, the incidence of DGP and the H. pylori infection rate gradually increased (P < 0.05). In the DGP group, the incidences of upper abdominal pain and distention, early satiety, and anorexia were 75.5%, 66.0%, and 67.9%, respectively, before eradication treatment; and 43.4%, 35.8%, and 39.6%, respectively, after eradication treatment, and the difference was statistically significant (P < 0.01). In patients with DGP with successful H. pylori eradication, the number of barium strips discharged after eradication was 5.9 ± 1.0, which was significantly larger than that before treatment (4.1 ± 0.7, P < 0.01). In addition, the number of barium strips discharged was significantly larger in patients with DGP with successful H. pylori eradication than those with failed H. pylori eradication (P < 0.01).Conclusions:DGP development might be associated with H. pylori infection. H. pylori eradication can effectively improve dyspepsia-associated symptoms and delayed gastric emptying in patients with DGP.

Helicobacter pylori causes delayed gastric emptying by decreasing interstitial cells of Cajal

“…The results of the present study showed that the gastric emptying rate of the mice infected with HP was significantly lower than that of noninfected mice, which is consistent with the results of previous studies ( 5 , 6 ).…”

“…Patients with DGE suffer from nutritional deficiencies and metabolic consequences as well as impairment of social activities and quality of life ( 18 , 35 ). There have been a number of studies on the relationship between HP infection and DGE, and it has been reported that HP infection can retard the gastric emptying function and induce DGE, but the specific mechanism has rarely been studied ( 5 , 6 ).…”

Management of Dyspepsia and Gastroparesis in Patients with Diabetes. A Clinical Point of View in the Year 2021

“…Many studies have analyzed the prevalence of H. pylori infection in symptomatic and asymptomatic patients with DM [ 32 , 33 , 34 ]. Hyperglycemia has been suggested as a predisposing factor for H. pylori colonization [ 32 ].…”

“…Among patients with DM, H. pylori infection has been shown to be higher in patients with gastroparesis, and bacterial eradication reduced symptoms such as upper abdominal pain and distention, early satiety and anorexia [ 34 ], thus suggesting a pathogenetic role of H. pylori in DG and reaffirming the therapeutic role of its eradication.…”

Helicobacter pylori Infection is Associated with Occurrence of Proteinuria in Type 2 Diabetes Patients

“…Within a large diabetic population, the prognosis of patients with proteinuria is serious, and there is a certain coping strategy for HP infection. [ 20 21 ] An increasing amount of research focuses on the interaction between HP infection and renal function. However, controversy still exists about the association between HP infection and the occurrence of proteinuria in T2DM patients.…”