Analysis of thyroid hormones in raw and treated waste water

Svanfelt, Jesper; Eriksson, Johan; Krönberg, Leif

doi:10.1016/j.chroma.2010.08.032

Cited by 37 publications

(28 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, important uncertainties are present in arriving at the net environmental load for this PhAC (see Appendix F). In addition, the treatment plant removal rate used for this PhAC results from the analysis of a single sample (76). Therefore, these uncertainties with respect to the environmental fate and loading of thyroxine indicate that further study of this PhAC is warranted.…”

Section: Prioritized Phacsmentioning

confidence: 96%

“…Upon its release to the environment, triiodothyronine is expected to be mobile and persistent (see Table IV) but it has yet to be monitored in drinking waters from Canada or elsewhere. In fact, to date, there is only the report of a single influent and a single (76). In both samples analyzed, triiodothyronine was found to be below the detection limit of 2-4 ng/L (76).…”

Section: Prioritized Phacsmentioning

confidence: 97%

“…To date, environmental monitoring of thyroxine within the Canadian environment has not been conducted. In fact, the measurement of thyroxine has only been reported in a single influent and a single effluent sample from a Finnish sewage treatment plant (76). Thyroxine was detected in both the influent and the effluent at levels of 64 and 22 ng/L, respectively.…”

Section: Prioritized Phacsmentioning

confidence: 98%

See 2 more Smart Citations

Human Health Relevance of Pharmaceutically Active Compounds in Drinking Water

Khan

Nicell

2015

AAPS J

View full text Add to dashboard Cite

In Canada, as many as 20 pharmaceutically active compounds (PhACs) have been detected in samples of treated drinking water. The presence of these PhACs in drinking water raises important questions as to the human health risk posed by their potential appearance in drinking water supplies and the extent to which they indicate that other PhACs are present but have not been detected using current analytical methods. Therefore, the goal of the current investigation was to conduct a screening-level assessment of the human health risks posed by the aquatic release of an evaluation set of 335 selected PhACs. Predicted and measured concentrations were used to estimate the exposure of Canadians to each PhAC in the evaluation set. Risk evaluations based on measurements could only be performed for 17 PhACs and, of these, all were found to pose a negligible risk to human health when considered individually. The same approach to risk evaluation, but based on predicted rather than measured environmental concentrations, suggested that 322 PhACs of the evaluation set, when considered individually, are expected to pose a negligible risk to human health due to their potential presence in drinking waters. However, the following 14 PhACs should be prioritized for further study: triiodothyronine, thyroxine, ramipril and its metabolite ramiprilat, candesartan, lisinopril, atorvastatin, lorazepam, fentanyl, atenolol, metformin, enalaprilat, morphine, and irbesartan. Finally, the currently available monitoring data for PhACs in Canadian surface and drinking waters was found to be lacking, irrespective of whether their suitability was assessed based on risk posed, predicted exposure concentrations, or potency.

show abstract

Section: Prioritized Phacsmentioning

confidence: 96%

Section: Prioritized Phacsmentioning

confidence: 97%

Section: Prioritized Phacsmentioning

confidence: 98%

See 1 more Smart Citation

Human Health Relevance of Pharmaceutically Active Compounds in Drinking Water

Khan

Nicell

2015

AAPS J

View full text Add to dashboard Cite

show abstract

“…It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate [84]. HPLC measurements of T-3 and T-4 enantiomers were performed on T and TAG aglycone CSPs, using H 2 O/MeOH mobile phase systems [85] (Table 2).…”

Section: Application Of Macrocyclic Glycopeptides-based Cspsmentioning

confidence: 99%

Recent advances in the direct and indirect liquid chromatographic enantioseparation of amino acids and related compounds: A review

Ilisz

Aranyi

Pataj

et al. 2012

Journal of Pharmaceutical and Biomedical Analysis

102

View full text Add to dashboard Cite

“…The thyroid hormones, which have important roles in many physiological 33 processes such as carbohydrate metabolism, oxygen consumption, protein synthesis 34 and foetal neuro development, are important tyrosine-based hormones produced by 35 the thyroid gland [1]. Among them, thyroxine (3,5,3,5-tetraiodolthyronine, T 4 ) is the 36 major thyroid hormone secreted from the thyroid gland.…”

mentioning

confidence: 99%

Ion pair hollow fiber liquid–liquid–liquid microextraction combined with capillary electrophoresis-ultraviolet detection for the determination of thyroid hormones in human serum

et al. 2014

Journal of Chromatography A

View full text Add to dashboard Cite

Analysis of thyroid hormones in raw and treated waste water

Cited by 37 publications

References 23 publications

Human Health Relevance of Pharmaceutically Active Compounds in Drinking Water

Human Health Relevance of Pharmaceutically Active Compounds in Drinking Water

Recent advances in the direct and indirect liquid chromatographic enantioseparation of amino acids and related compounds: A review

Ion pair hollow fiber liquid–liquid–liquid microextraction combined with capillary electrophoresis-ultraviolet detection for the determination of thyroid hormones in human serum

Contact Info

Product

Resources

About