Assessment of the occupational risk of oil industry workers is an important aspect of compliance with safety requirements at oil industry enterprises in the extraction of energy resources. Solving the engineering problems facing the extraction of energy resources, including the tasks of assessing occupational risk, it is necessary to take into account as many factors as possible that affect the safe performance of work on the extraction of energy resources. The article deals with the impact of workers’ fatigue on their safety, and also a methodology for assessing the occupational risk of oil industry workers taking into account their fatigue is developed.