Analysis of trajectories of eye, head, and hand movements for early diagnosis of Parkinson’s disease

Baziyan, B. Kh.; Чигалейчик, Л.А.; Тесленко, Е.Л.; Lachinova, D. R.

doi:10.1007/s10517-007-0177-9

Cited by 7 publications

(7 citation statements)

References 2 publications

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“…Parkinsonian syndrome is an example of how dysfunction of inhibition, which occurs on the level of subcortical structures, can induce saccadic disorders. 1 In a number of studies of patients with Parkinson disease saccadic disorders similar to those described in the present study were observed [16][17][18][19] It should be emphasized that in some cases HIE induced disorders of saccadic electrophysiological parameters were even more pronounced than in Parkinson's patients (in particular three HIE subjects with clearly expressed hypokinetic syndrome). In comparison with Parkinson's patients HIE subjects with hypokinetic syndrome were characterized by increased instability of the latent period of saccades in the coordinated test and a pronounced disturbance of gaze stabilization after termination of saccades that was manifested by tremor eye movement of different amplitudes.…”

Section: Discussionsupporting

confidence: 82%

“…The fourth level consists of different zones of hemispheric brain cortex: frontal, rear parietal and occipital lobes, prestriar cortex, additional eye movement fields, dorsolateral frontal eye field (Brodmann's area 8) and the posterior cingulate. Disorders in the oculomotor system have been investigated in patients with different syndromes: schizophrenia [10][11][12], attention-deficit/hyperactivity disorder [13][14][15], Parkinson's disease [16][17][18][19], and Alzheimer's disease [20]. However, data on HIE influence of saccadic eye movements are rather scarce.…”

Section: Introductionmentioning

confidence: 99%

“…This suggests that due to superimposition of these pathological changes the likelihood of detecting motor disorders at the earliest stages of a disease is significantly increased during implementation of coordinated movement. In a former study performed on patients in the early stages of Parkinson's disease, saccade impairment not detected by Test 1 were significantly expressed during the coordinated test [18,19].…”

Section: Introductionmentioning

confidence: 99%

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Saccadic dysfunction in patients with hypoxic-ischemic encephalopathy

2018

J. Integr. Neurosci.

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Electrophysiological monitoring of saccadic eye movements in patients with hypoxic-ischemic encephalopathy was carried out. Externally guided saccades (prosaccades) were recorded using a patented hardware-software complex for studying a subject's physical activity. Recordings were performed in two independent experimental procedures -for saccades separately and when they were coordinated with movement of the head and hand. In both cases statistically significant differences of latent period and duration of saccadic eye movement were detected for hypoxic-ischemic encephalopathy subjects in comparison with healthy controls of the same age (p < 0.05). Jerking and deviation of eyes after gaze fixation on a target were often present in hypoxicischemic encephalopathy subjects. In some cases saccades of these subjects were asymmetrical among themselves. Hypoxicischemic encephalopathy induced changes in the parameters of autosaccades were also found They were expressed through instability of gaze fixation periods, sometimes asymmetric eye movements, slow gaze shift from one target to another, and disturbance of gaze stabilization (jerking of eyeballs during the saccadic period).

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Saccadic dysfunction in patients with hypoxic-ischemic encephalopathy

2018

J. Integr. Neurosci.

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“…It is assumed that, in PD patients, reaching movement is limited by decreased movement of the upper limbs due to akinesia or bradykinesia, decreased flexibility due to rigidity of the four limbs and trunk, and the impairment of postural reflexes associated with these decreases. Moreover, it has been reported that PD patients experience disorders in eye movement [16–18] and coordination between the eyes and head with reaching movements [19–21]. Presumably, decreased motility of the eyes, head, and neck due to PD may affect the ability to detect the accurate position of a target object in space.…”

Section: Introductionmentioning

confidence: 99%

The Cognition of Maximal Reach Distance in Parkinson’s Disease

Otsuki

Nagaoka

2016

Parkinson's Disease

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This study aimed to investigate whether the cognition of spatial distance in reaching movements was decreased in patients with Parkinson's disease (PD) and whether this cognition was associated with various symptoms of PD. Estimated and actual maximal reaching distances were measured in three directions in PD patients and healthy elderly volunteers. Differences between estimated and actual measurements were compared within each group. In the PD patients, the associations between “error in cognition” of reaching distance and “clinical findings” were also examined. The results showed that no differences were observed in any values regardless of dominance of hand and severity of symptoms. The differences between the estimated and actual measurements were negatively deviated in the PD patients, indicating that they tended to underestimate reaching distance. “Error in cognition” of reaching distance correlated with the items of posture in the motor section of the Unified Parkinson's Disease Rating Scale. This suggests that, in PD patients, postural deviation and postural instability might affect the cognition of the distance from a target object.

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“…However, most systems based on technology eye-tracking, for the successful operation require new methods of mathematical description of human eye-motor system (EMS) and special equipment for experimental research [5][6][7].…”

mentioning

confidence: 99%

Identification of human eye-motor system base on Volterra model

Pavlenko

Fomin

Федорова

et al. 2016

Bulletin of the National Technical University "KhPI". A Series of "Information and Modeling"

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A new method of constructing nonparametric dynamic model of the human oculomotor system on the basis of experimental data "input-output". This takes into account nonlinear and inertial properties of the eye of the rectus muscles. A technology for tracking eye movement based on the videos. It is possible to determine the dynamic characteristics of the oculomotor system functions as a transition of the first and second order-integral transforms Volterra kernels. Refs: 14 titles.

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Analysis of trajectories of eye, head, and hand movements for early diagnosis of Parkinson’s disease

Cited by 7 publications

References 2 publications

Saccadic dysfunction in patients with hypoxic-ischemic encephalopathy

Saccadic dysfunction in patients with hypoxic-ischemic encephalopathy

The Cognition of Maximal Reach Distance in Parkinson’s Disease

Identification of human eye-motor system base on Volterra model

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