We investigated reaction cross section and inelastic collisions of the wide number of projectile and target nuclei using the Coulomb Modified Glauber Model (CMGM). The total reaction cross sections were calculated with and without accounting for in-medium effect for various heavy projectiles such as 56Fe26, 84Kr36, 132Xe54, 197Au79 and 238U92 that interact with Nuclear Emulsion Detector’s (NED) nuclei at incident energies at around 1 GeV/n. The calculated average values of reaction cross section are compared with the corresponding experimental data.