Analysis of volatile compounds by open-air ionization mass spectrometry

Meher, Anil Kumar; Chen, Yu-Chie

doi:10.1016/j.aca.2017.03.005

Cited by 7 publications

(10 citation statements)

References 37 publications

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“…The exchange of hydrogen/ deuterium has provided very valuable mechanistic insights since the initial developments of chemical ionization/massspectrometry. [29][30][31][32] We hypothesized that, if the neutral vapors interact with the electrospray charged droplets to be re-emitted as gas-phase ions, they should be detected as [M + D] + ions.…”

Section: Resultsmentioning

confidence: 99%

Secondary electrospray ionization proceeds via gas-phase chemical ionization

2017

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Section: Resultsmentioning

confidence: 99%

Secondary electrospray ionization proceeds via gas-phase chemical ionization

2017

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“…In addition to spray-based ionization techniques [ 203 – 206 ], mass spectrometry imaging (MSI) is another useful technique for food safety and quality control through monitoring the spatial distribution of bioactive components and contaminants in food samples. Until recently, MSI was largely performed with MALDI.…”

Section: Ms-based Approaches For Food Analysismentioning

confidence: 99%

MS-Based Analytical Techniques: Advances in Spray-Based Methods and EI-LC-MS Applications

Bianchi

Riboni

Termopoli³

et al. 2018

Journal of Analytical Methods in Chemistry

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Mass spectrometry is the most powerful technique for the detection and identification of organic compounds. It can provide molecular weight information and a wealth of structural details that give a unique fingerprint for each analyte. Due to these characteristics, mass spectrometry-based analytical methods are showing an increasing interest in the scientific community, especially in food safety, environmental, and forensic investigation areas where the simultaneous detection of targeted and nontargeted compounds represents a key factor. In addition, safety risks can be identified at the early stage through online and real-time analytical methodologies. In this context, several efforts have been made to achieve analytical instrumentation able to perform real-time analysis in the native environment of samples and to generate highly informative spectra. This review article provides a survey of some instrumental innovations and their applications with particular attention to spray-based MS methods and food analysis issues. The survey will attempt to cover the state of the art from 2012 up to 2017.

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“…23−27,29−31,35−42 It has been demonstrated that AIMS can be simplified without the need to make any direct electric contact to the ionization emitter when a high voltage is applied to the orifice of the mass spectrometer. [23][24][25][26][27][29][30][31][35][36][37][38][39][40]42 This is because the high electric field provided in the mass spectrometer system is capable of inducing ionization through either electrospray 21,23,25−27,29−31,36−40 or corona discharge. [23][24][25][26]35,42 These approaches are called as field-induced 21 or contactless ionization methods.…”

Section: ■ Introductionmentioning

confidence: 99%

“…[23][24][25][26][27][29][30][31][35][36][37][38][39][40]42 This is because the high electric field provided in the mass spectrometer system is capable of inducing ionization through either electrospray 21,23,25−27,29−31,36−40 or corona discharge. [23][24][25][26]35,42 These approaches are called as field-induced 21 or contactless ionization methods. [23][24][25][26][27][29][30][31][35][36][37][38][39][40]42 For example, when a small piece of insulating fiber 23 or one piece of electric conductive material 25,26,39 was placed close to the metal inlet of the mass spectrometer, which was applied with a high voltage, volatiles or semivolatiles derived from the solid sample deposit on the fiber could be readily ionized and detected by the mass spectrometer.…”

Section: ■ Introductionmentioning

confidence: 99%

Utilizing a Metal Inlet Coiled with Copper Wire as the Ion Source for Ambient Ionization Mass Spectrometry

Tu,

Chen

2024

Anal. Chem.

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In ambient ionization mass spectrometry (MS), a customized metal inlet is typically adapted to the orifice of the mass spectrometer for ease of introduction of the sample. We herein explore that the metal inlet coiled with a copper wire (∼50 μm) can be directly used as an ion source to induce corona discharge-like processes for ionization of analytes in the gas phase. When the metal inlet is subjected to a high voltage in the mass spectrometer, the electric field provided by the mass spectrometer enables the generation of corona discharge to ionize volatile/semivolatile analytes derived from the sample in the condensed phase. The limit of detection for azulene derived from the aqueous sample was as low as ∼1 pM. Moreover, we also demonstrated the feasibility of coupling ultraviolet−visible absorption spectroscopy with MS by using the metal inlet coiled with a thin copper wire as the interface. Integration of these two techniques enables the simultaneous acquisition of spectra from both instruments for quantitative and qualitative analysis of the sample. Furthermore, we showed that polar and nonpolar analytes in a mixture can be acquired in the same mass spectrum by simply depositing a sample droplet (∼20 μL) on a dielectric substrate near the copper wire-coiled metal inlet of the mass spectrometer. The ionization processes involved both electrospray ionization and corona discharge. To demonstrate the applicability of our method for detecting nonpolar and polar analytes in complex samples, we spiked a nonpolar analyte, benzo[a]pyrene, to a spice sample and successfully detected analytes with different polarities using our approach.

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Analysis of volatile compounds by open-air ionization mass spectrometry

Cited by 7 publications

References 37 publications

Secondary electrospray ionization proceeds via gas-phase chemical ionization

Secondary electrospray ionization proceeds via gas-phase chemical ionization

MS-Based Analytical Techniques: Advances in Spray-Based Methods and EI-LC-MS Applications

Utilizing a Metal Inlet Coiled with Copper Wire as the Ion Source for Ambient Ionization Mass Spectrometry

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