Analysis of volatile organic compounds from patients and cell lines for the validation of lung cancer biomarkers by proton-transfer-reaction mass spectrometry

Sun, Yun; Chen, Yibing; Sun, Changku; Liu, Hai-Pei; Wang, Yan; Jiang, Xuehui

doi:10.1039/c9ay00759h

Cited by 20 publications

(20 citation statements)

References 46 publications

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“…A total of 139 studies were included in the present review. From the total of 60 cross-sectional clinical studies selected [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 ], 33 ...…”

Section: Statistics Of Included Studiesmentioning

confidence: 99%

“…From the total number of participants, 421 were children with 229 children having asthma and 192 children acting as the controls. Of the selected clinical studies, thirty-two of them reported that they used mixed expired breath [ 13 , 17 , 19 , 21 , 33 , 34 , 36 , 38 , 41 , 42 , 43 , 45 , 46 , 54 , 59 , 60 , 61 , 62 , 64 , 66 , 67 , 68 , 69 , 71 , 72 , 73 , 75 , 76 , 78 , 80 , 83 , 85 ] (consisting normally in a mixture of gaseous breath, that also includes the volatile components) collected by simple expiration in bags, tubes with absorbent materials or directly into the used instrumentation (as in the case of E-noses, for example). A total of twenty-two of them reported the use of alveolar breath [ 14 , 15 , 16 , 18 , 22 , 32 , 35 , 37 , 44 , 48 , 56 , 57 , 58 , 65 , 70 , 74 , 77 , 79 , 81 , 82 , 84 , …”

Section: Statistics Of Included Studiesmentioning

confidence: 99%

“…Although the cost of a SESI-MS is lower than that of a GC-MS, it has only been rarely used. PTR-MS was used in two studies of lung cancer [ 33 , 34 ], and one study for discriminating COPD and emphysema [ 32 ]. SESI-MS was involved in a single study for COPD diagnosis [ 20 ].…”

Section: Analytical Platforms Used For Investigating Breath Volatimentioning

confidence: 99%

“…Adenocarcinoma and squamous cell carcinoma subtypes were discriminated in a PTR-MS study. The authors claim that breath volatiles from adenocarcinoma and squamous cell carcinoma patients can help in identification of cancer subtypes [ 34 ].…”

Section: Diagnosis Of Investigated Respiratory Diseasesmentioning

confidence: 99%

“…This review will cover studies of lung diseases that have used various analytical platforms for breath analyses [ 31 ], including proton-transfer reaction mass spectrometry (PTR-MS) [ 32 , 33 , 34 ], secondary electrospray ionization—mass spectrometry (SESI-MS) [ 20 ], ion mobility spectrometry (IMS) [ 18 , 35 , 36 , 37 ], various sensors and E-noses [ 15 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ] and gas chromatography–mass spectrometry (GC–MS) [ 43 , 44 , 45 , 46 , 47 , 48 ].…”

Section: Introductionmentioning

confidence: 99%

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Volatile Organic Compounds in Exhaled Breath as Fingerprints of Lung Cancer, Asthma and COPD

Rațiu

Ligor

Bocoş-Binţinţan

et al. 2020

JCM

116

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Lung cancer, chronic obstructive pulmonary disease (COPD) and asthma are inflammatory diseases that have risen worldwide, posing a major public health issue, encompassing not only physical and psychological morbidity and mortality, but also incurring significant societal costs. The leading cause of death worldwide by cancer is that of the lung, which, in large part, is a result of the disease often not being detected until a late stage. Although COPD and asthma are conditions with considerably lower mortality, they are extremely distressful to people and involve high healthcare overheads. Moreover, for these diseases, diagnostic methods are not only costly but are also invasive, thereby adding to people’s stress. It has been appreciated for many decades that the analysis of trace volatile organic compounds (VOCs) in exhaled breath could potentially provide cheaper, rapid, and non-invasive screening procedures to diagnose and monitor the above diseases of the lung. However, after decades of research associated with breath biomarker discovery, no breath VOC tests are clinically available. Reasons for this include the little consensus as to which breath volatiles (or pattern of volatiles) can be used to discriminate people with lung diseases, and our limited understanding of the biological origin of the identified VOCs. Lung disease diagnosis using breath VOCs is challenging. Nevertheless, the numerous studies of breath volatiles and lung disease provide guidance as to what volatiles need further investigation for use in differential diagnosis, highlight the urgent need for non-invasive clinical breath tests, illustrate the way forward for future studies, and provide significant guidance to achieve the goal of developing non-invasive diagnostic tests for lung disease. This review provides an overview of these issues from evaluating key studies that have been undertaken in the years 2010–2019, in order to present objective and comprehensive updated information that presents the progress that has been made in this field. The potential of this approach is highlighted, while strengths, weaknesses, opportunities, and threats are discussed. This review will be of interest to chemists, biologists, medical doctors and researchers involved in the development of analytical instruments for breath diagnosis.

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Section: Statistics Of Included Studiesmentioning

confidence: 99%

Section: Statistics Of Included Studiesmentioning

confidence: 99%

Section: Analytical Platforms Used For Investigating Breath Volatimentioning

confidence: 99%

Section: Diagnosis Of Investigated Respiratory Diseasesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Volatile Organic Compounds in Exhaled Breath as Fingerprints of Lung Cancer, Asthma and COPD

Rațiu

Ligor

Bocoş-Binţinţan

et al. 2020

JCM

116

View full text Add to dashboard Cite

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Covalent Organic Framework as Selective Fluorescence Sensors for Cancer Inducing Volatile Organic Compounds

Mekkeparambath,

Sreejaya,

et al. 2024

ChemBioChem

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Certain volatile organic compounds (VOCs), such as formaldehyde, acetone, and ethanol, are overexpressed in some terminal diseases like cancer, diabetes, Alzheimer’s, etc. Therefore, high‐precision detection and quantification of VOCs is imperative for early diagnosis of such detrimental diseases. Non‐invasive and accurate fluorescence‐based detection of such analytes has garnered widespread attention. The inherent luminescent properties of covalent organic frameworks (COFs), resulting from their extensive π‐conjugation, have made them suitable for sensing applications. Structural tunability and strong covalent linkers facilitate sensing by COFs. Appropriate choices of linker and skeletal units of the COF can help detect various biologically important analytes selectively. The most common linkers used in this regard is the imine linker, which can undergo excellent hydrogen bonding with different protic VOCs e.g., ethanol, methanol, etc. Besides imine detection, hydrogen bonding also proved useful for detection of aldehydes. Suitable combinations of donors and acceptors enable the COFs to have specific charge transfer interactions with many electron‐rich and electron‐poor VOCs. In this review, we have highlighted the syntheses of selective COFs incorporating linkers designed for sensing cancer‐inducing VOCs. A detailed discussion of the interaction mechanisms between COFs and these VOCs is provided, along with examples from recent literature in this field.

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Volatile organic compounds in cancer and exhaled breath detection technology

Zhou,

Qi,

Tang

et al. 2024

Advances in Clinical Chemistry

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Analysis of volatile organic compounds from patients and cell lines for the validation of lung cancer biomarkers by proton-transfer-reaction mass spectrometry

Abstract: Exhaled breath samples from 60 volunteers (30 lung cancer patients, 30 healthy people), and headspace VOCs from lung cancer cells (A549 and H1703) were analyzed using proton-transfer-reaction mass spectrometry (PTR-MS).

Cited by 20 publications

References 46 publications

Volatile Organic Compounds in Exhaled Breath as Fingerprints of Lung Cancer, Asthma and COPD

Volatile Organic Compounds in Exhaled Breath as Fingerprints of Lung Cancer, Asthma and COPD

Covalent Organic Framework as Selective Fluorescence Sensors for Cancer Inducing Volatile Organic Compounds

Volatile organic compounds in cancer and exhaled breath detection technology

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