Analysis on DNA sequence of TSHB gene and its association with reproductive seasonality in goats

Huang, Dali; Wang, J.; Liu, Q. Y.; Chu, Mingxing; Di, Ran; He, Jianning; Cao, G. L.; Li, Fang; Feng, Tao; Li, N.

doi:10.1007/s11033-012-2245-0

Cited by 17 publications

(12 citation statements)

References 60 publications

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“…In fact, high levels of TSH are commonly found in obese human children and adolescents [ 54 ]. In goat, this gene has been characterized in relation with reproductive seasonality [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

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Signatures of selection and environmental adaptation across the goat genome post-domestication

Bertolini¹,

Servin²,

Talenti³

et al. 2018

Genet Sel Evol

140

109

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BackgroundSince goat was domesticated 10,000 years ago, many factors have contributed to the differentiation of goat breeds and these are classified mainly into two types: (i) adaptation to different breeding systems and/or purposes and (ii) adaptation to different environments. As a result, approximately 600 goat breeds have developed worldwide; they differ considerably from one another in terms of phenotypic characteristics and are adapted to a wide range of climatic conditions. In this work, we analyzed the AdaptMap goat dataset, which is composed of data from more than 3000 animals collected worldwide and genotyped with the CaprineSNP50 BeadChip. These animals were partitioned into groups based on geographical area, production uses, available records on solid coat color and environmental variables including the sampling geographical coordinates, to investigate the role of natural and/or artificial selection in shaping the genome of goat breeds.ResultsSeveral signatures of selection on different chromosomal regions were detected across the different breeds, sub-geographical clusters, phenotypic and climatic groups. These regions contain genes that are involved in important biological processes, such as milk-, meat- or fiber-related production, coat color, glucose pathway, oxidative stress response, size, and circadian clock differences. Our results confirm previous findings in other species on adaptation to extreme environments and human purposes and provide new genes that could explain some of the differences between goat breeds according to their geographical distribution and adaptation to different environments.ConclusionsThese analyses of signatures of selection provide a comprehensive first picture of the global domestication process and adaptation of goat breeds and highlight possible genes that may have contributed to the differentiation of this species worldwide.Electronic supplementary materialThe online version of this article (10.1186/s12711-018-0421-y) contains supplementary material, which is available to authorized users.

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“…In fact, high levels of TSH are commonly found in obese human children and adolescents [ 54 ]. In goat, this gene has been characterized in relation with reproductive seasonality [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

“…Another gene that could be linked to the reproductive seasonality is TSHB , which has been reported to be associated with meat production and reproductive seasonality in goats [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Signatures of selection and environmental adaptation across the goat genome post-domestication

Bertolini¹,

Servin²,

Talenti³

et al. 2018

Genet Sel Evol

140

109

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“…Amplification conditions were as follows: initial denaturation at 95°C for 5 min; followed by 32 cycles of denaturation at 95°C for 30 s, annealing for 30 s at appropriate temperatures (Table 1), extension at 72°C for 30 s; with a final extension at 72°C for 5 min on Mastercycler 5333 (Eppendorf AG, Hamburg, Germany). The PCR products were cloned and sequenced as described previously (Huang et al 2013).…”

Section: Methodsmentioning

confidence: 99%

Tissue-specific mRNA expression profiles of GDF9, BMP15, and BMPR1B genes in prolific and non-prolific goat breeds

Pan¹,

Di²,

Tang³

et al. 2015

Czech J. Anim. Sci.

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ABSTRACT:The tissue-specific mRNA expression profiles of GDF9, BMP15, and BMPR1B genes in goats were investigated. The mRNA expression of the genes was detected in prolific Jining Grey goats and non-prolific Liaoning Cashmere goats by reverse transcription polymerase chain reaction (RT-PCR) and quantitative real-time PCR. The results showed that GDF9 and BMPR1B were widely expressed in 20 tissues, while BMP15 gene was expressed exclusively in ovary and pituitary. The expression levels of GDF9 and BMPR1B genes were the highest in ovary. The expression level of BMP15 gene in the ovary of Jining Grey goat was 4.96-fold higher than that in Liaoning Cashmere goat (P < 0.05), but there were no differences (P > 0.05) in the expression level of GDF9 and BMPR1B genes. This is the first study to analyze the tissue expression pattern of GDF9, BMP15, and BMPR1B genes in goat, and the BMP15 might be a major gene for the prolificacy of Jining Grey goat.

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“…In Chinese goat breeds, the association between litter size and a wide array of polymorphisms mapping to the BMP4 [71], CART [72], GDF9 [73,74], GNRH1 [74], INHA and INHBA [75], KISS1 [76][77][78], KITLG [79], POUF1 [80], and TSHB [81] genes, amongst others, has been screened. However, the most significant finding in the field of caprine reproduction genetics has been the elucidation of the molecular basis of the goat polled intersex syndrome (PIS).…”

Section: Candidate Genes For Reproduction Traitsmentioning

confidence: 99%

The Application of Genomic Technologies to Investigate the Inheritance of Economically Important Traits in Goats

Amills

2014

Advances in Biology

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Goat genomics has evolved at a low pace because of a lack of molecular tools and sufficient investment. Whilst thousands and hundreds of quantitative trait loci (QTL) have been identified in cattle and sheep, respectively, about nine genome scans have been performed in goats dealing with traits as conformation, growth, fiber quality, resistance to nematodes, and milk yield and composition. In contrast, a great effort has been devoted to the characterization of candidate genes and their association with milk, meat, and reproduction phenotypes. In this regard, causal mutations have been identified in the S1 -casein gene that has a strong effect on milk composition and the PIS locus that is linked to intersexuality and polledness. In recent times, the development of massive parallel sequencing technologies has allowed to build a reference genome for goats as well as to monitor the expression of mRNAs and microRNAs in a broad array of tissues and experimental conditions. Besides, the recent design of a 52K SNP chip is expected to have a broad impact in the analysis of the genetic architecture of traits of economic interest as well as in the study of the population structure of goats at a worldwide scale.

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Analysis on DNA sequence of TSHB gene and its association with reproductive seasonality in goats

Cited by 17 publications

References 60 publications

Signatures of selection and environmental adaptation across the goat genome post-domestication

Signatures of selection and environmental adaptation across the goat genome post-domestication

Tissue-specific mRNA expression profiles of GDF9, BMP15, and BMPR1B genes in prolific and non-prolific goat breeds

The Application of Genomic Technologies to Investigate the Inheritance of Economically Important Traits in Goats

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