Analysis on the Clinical Characteristics of 36 Cases of Novel Coronavirus Pneumonia in Kunming

Abstract

Objective: To analyze the clinical characteristics of patients with novel coronavirus pneumonia in Kunming City, and to study the correlation between nutritional status and immune function. Methods: Clinical data of 36 patients with novel coronavirus pneumonia in isolation area of Kunming Third People's Hospital from January 31 to February 15, 2020 were collected, and the basic situation, clinical characteristics, laboratory examination and CT imaging characteristics were analyzed. Serum albumin (ALB), prealbumin (PAB), hypersensitive c-reactive protein (hs-crp), CD3T cells, CD4T cells, CD8T cells and normal control group were analyzed. A simple linear regression analysis of the relationship between proalbumin and T cell subpopulation counts in the blood of patients. Results:(1) The patients with new coronavirus pneumonia in Kunming were mainly of common type. (2) 50% of the patients' first symptoms were fever and cough; (3) The total number of white blood cells in peripheral blood was normal or decreased in 23 cases (79%), and the lymphocyte count decreased in 5 cases (13.89%), without anemia. Hypersensitive c-reactive protein increased in 19 (52.78%) cases, and procalcitonin increased in 1 case. Albumin decreased in 5 cases (13.89%), proalbumin decreased in 15 cases (41.67%), alanine transaminase increased slightly in 4 cases (11.11%), alanine transaminase increased slightly in 4 cases (11.11%), total bilirubin increased slightly in 11 cases (30.56%), and renal function and blood coagulation were normal. Absolute value of CD3 + T cells is with a decrease in 21 cases (58.3%), CD4 + T in 28 cases (77.8%), CD8 + T in 17 cases (47.2%), and CD4 + / CD8 + inverse in 6 cases (16.7%). (4) The prealbumin, CD3 T cells, CD4 T cells and CD8 T cells in the new coronavirus pneumoniagroup were significantly lower than those in the normal control group, and the hypersensitive c-reactive protein was higher than that in the normal control group. (5) The levels of PAB in the serum of the patients were linearly correlated with hs-crp, CD3 T cells, CD4 T cells and CD8 T cells, and the correlation coefficients were -0.474, 0.558, 0.467 and 0.613, respectively, showing statistical differences. Conclusion: The clinical characteristics of the novel coronavirus pneumonia in Kunming are different from those in Wuhan. The changes of serum proalbumin and T cell subsets are relatively obvious. Changes in serum proalbumin may contribute to the early warning of novel coronavirus pneumonia. The nutritional status of patients with common and mild pneumonia should be considered.

Diabetes mellitus increases the risk of hospital mortality in patients with Covid-19

“…Among the 16 observational studies,[ 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 ] 12 were performed at a single center and 4 were multicenter studies. The sample sizes ranged widely across studies (median 90 patients; range 24 to 416 patients).…”

AGA Institute Rapid Review of the Gastrointestinal and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for the Consultative Management of Patients with COVID-19

“…A total of 43 studies including 10,676 COVID-19 patients (confirmed by laboratory real-time reverse transcription polymerase chain reaction [RT-PCR] testing) were included in the overall analysis. [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]37,38,41,42,45,47,[49][50][51][52][53][54][55]58,59,[62][63][64][65][66][67][68][69][70][71]73,76 The pooled prevalence of diarrhea symptoms across these studies was 7.7% (95% CI, 7.2%-8.2%). When analyzing by country (studies from China vs studies from other countries), the pooled prevalence of diarrhea in studies from countries other than China was much higher at 18.3% (95% CI, 16.6%-20.1%).…”

“…In hospitalized patients, across 39 studies including 8,521 patients, the pooled prevalence was slightly higher at 10.4% (95% CI, 9.4%-10.7%) compared with outpatients. [20][21][22][23][25][26][27][28]30,[33][34][35]38,41,42,[44][45][46][49][50][51][52][53][54][55]60,[62][63][64][65][66][67][68][70][71][72][73][74]76 In 3 studies including 1701 outpatients, the pooled prevalence was 4.0% (95% CI, 3.1%-5.1%). 31,59,63 As part of the sensitivity analysis, we identified 35 studies including 9717 patients that described diarrhea, and explicitly reported that it was one of the initial presenting sympto ms. [20][21][22][23][26][...…”

“…A total of 33 studies including 8070 patients reported on hospitalized COVID-19 patients presenting with diarrhea as one of the initial symptoms of COVID-19. [20][21][22][23][26][27][28][33][34][35]38,41,42,44,45,48,[50][51][52][53][54][55]60,[63][64][65][66]68,[70][71][72][73]76 The pooled prevalence was 9.3% (95% CI, 8.6%-9.9%) ( Supplementary Figures 3-6).…”

A Review of the Importance of Atypical Otorhinolaryngological Symptoms in the Screening of COVID-19 Patients

“…Among the 20 research articles included in the analysis, fever was found to be a dominant symptom in most of the articles [9,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] (Fig. 1) as main stress was given on flulike symptoms except for one study in which fever onset was absent and gastrointestinal symptoms were the initial presentation in coronavirus infected pneumonia patients [26].…”