Analytical Discrimination of Poisonous and Nonpoisonous Chemotypes of Giant Fennel (<i>Ferula communis</i> L.) through Their Biologically Active and Volatile Fractions

Rubiolo, Patrizia; Matteodo, Maura; Riccio, Giovanna; Ballero, Mauro; Christen, Philippe; Fleury-Souverain, Sandrine; Veuthey, Jean‐Luc; Bicchi, Carlo

doi:10.1021/jf061592t

Cited by 45 publications

(30 citation statements)

References 25 publications

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“…Several species such as Thymus spp. (Figueiredo et al 2008b), Lavandula pedunculata (Zuzarte et al 2009), Ferula communis (Rubiolo et al 2006), and Foeniculum vulgare (Krüger and Hammer 1999) ISO 19332:2007). Analytical standards and monographs like those of the ISO and Pharmacopoeias have been published and should be considered in order to produce and commercialize consistent and safe products.…”

Section: Important Trade Essential Oilsmentioning

confidence: 99%

Essential Oils Chemistry

Zuzarte

Salgueiro

2015

Bioactive Essential Oils and Cancer

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Section: Important Trade Essential Oilsmentioning

confidence: 99%

Essential Oils Chemistry

Zuzarte

Salgueiro

2015

Bioactive Essential Oils and Cancer

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“…[26] Also, giant fennel (Ferula communis L.) is characterized by two chemotypes; one is poisonous, due to the presence of prenylcoumarins, and the other is non-poisonous and contains daucane esters. [27] …”

Section: Genetic Factorsmentioning

confidence: 99%

Raw materials: the importance of quality and safety. A review.

Salgueiro

Martins

Correia

2010

Flavour & Fragrance J

111

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Aromatic plants and spices are used throughout the world for fl avouring food and beverages, as well as for food supplements, novel foods and as a source of essential oils and aromatic extracts. The non-availability or inadequacy of standards for checking and assuring the quality of aromatic plants and spices is one of the main problems that arise for industry when using such raw materials. As many aromatic plants are harvested from the wild, standardization to assure their quality is important for their safe and eff ective utilization in food and beverage industries. On the other hand, there are numerous parameters that infl uence the chemical composition of plants, which play an important role in the fi nal quality of the product and possibly in any risk arising to the consumer. Also, from a safety point of view, aromatic plants and spices should be free of undeclared contaminants and adulterants, such as toxic botanicals, pathogenic microorganisms and excessive levels of microbial toxins, pesticides or fumigation agents. We focus on these aspects and examine ways to assure their appropriate utilization from the quality and safety standpoint. The regulatory situation of medicinal and aromatic plants (MAPs) is very complicated; several diff erences in standards and regulations between countries can be found, a situation that can result in more health risks arising for consumers. To clarify some of the existing problems, the major regulations of the USA and the European Union (EU) and the borderlines between food supplements and medicines and other international standards, are briefl y described and discussed.

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“…-T he specieso ft he genus Ferula L. represent ar ich source of biologically active secondary metabolites and have been widely investigated duringthe last two decades.Plants of this genus have been used in the traditional medicine since ancient times,most frequently as antispasmodic, anthelmintic,antiflatulence,antidiarrheal, wound-healing, aphrodisiac,a nd antidiabeticr emedies [1][2][3][4].A dditionally, asafoetida, an oleo-gum resin obtained mainly from the underground parts of F. assafoetida L. (but also from F. aliacea Boiss., F. foetida Regel, F. narthex Boiss., F. rigidula Fisch.exDC.,and F. rubricaulis Boiss.) is commonly used in human diet, especially in India and Nepal [1].Onthe other hand, atoxic variety of F. communis L. is responsible for the lethal hemorrhagic syndromek nown as ferulosis,w hich mainly affects cattle and horses [5]. It was recently shown that isolates of F. assa-foetida, F. szowitsiana D. C., F.…”

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confidence: 99%

Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffeliiGriseb. ex Heuff. and Its Metabolites

Pavlović

Petrović

Milenković

et al. 2015

Chemistry & Biodiversity

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The antimicrobial and cytotoxic activities of isolates (CHCl3 and MeOH extracts and selected metabolites) obtained from the underground parts of the Balkan endemic plant Ferula heuffelii Griseb. ex Heuff. were assessed. The CHCl3 and MeOH extracts exhibited moderate antimicrobial activity, being more pronounced against Gram-positive than Gram-negative bacteria, especially against Staphylococcus aureus (MIC=12.5 μg/ml for both extracts) and Micrococcus luteus (MIC=50 and 12.5 μg/ml, resp.). Among the tested metabolites, (6E)-1-(2,4-dihydroxyphenyl)-3,7,11-trimethyl-3-vinyldodeca-6,10-dien-1-one (2) and (2S*,3R*)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2,3-dihydro-7-hydroxy-2,3-dimethylfuro[3,2-c]coumarin (4) demonstrated the best antimicrobial activity. Compounds 2 and 4 both strongly inhibited the growth of M. luteus (MIC=11.2 and 5.2 μM, resp.) and Staphylococcus epidermidis (MIC=22.5 and 10.5 μM, resp.) and compound 2 additionally also the growth of Bacillus subtilis (MIC=11.2 μM). The cytotoxic activity of the isolates was tested against three human cancer cell lines, viz., cervical adenocarcinoma (HeLa), chronic myelogenous leukemia (K562), and breast cancer (MCF-7) cells. The CHCl3 extract exhibited strong cytotoxic activity against all cell lines (IC50 <11.0 μg/ml). All compounds strongly inhibited the growth of the K562 and HeLa cell lines. Compound 4 exhibited also a strong activity against the MCF-7 cell line, comparable to that of cisplatin (IC50 =22.32±1.32 vs. 18.67±0.75μM).

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Analytical Discrimination of Poisonous and Nonpoisonous Chemotypes of Giant Fennel (Ferula communis L.) through Their Biologically Active and Volatile Fractions

Cited by 45 publications

References 25 publications

Essential Oils Chemistry

Essential Oils Chemistry

Raw materials: the importance of quality and safety. A review.

Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffeliiGriseb. ex Heuff. and Its Metabolites

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