Analytical method for the biomonitoring of bisphenols and parabens by liquid chromatography coupled to tandem mass spectrometry in human hair

Robin, Julien; Binson, Guillaume; Albouy, Marion; Sauvaget, Alexis; Pierre-Eugène, Pascale; Migeot, Virginie; Dupuis, Antoine; Venisse, Nicolas

doi:10.1016/j.ecoenv.2022.113986

Cited by 15 publications

(7 citation statements)

References 39 publications

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“…In the urine or serum levels of these substances are subject to frequent fluctuation with the increase in the concentration levels after exposure and their decrease after a relatively short period of time [ 48 ]. Previous studies have shown that even after a single exposure, the levels of parabens may increase in the serum and urine, and after some hours or days, due to the fact that parabens are substances with short elimination half-lives, these levels may decrease significantly [ 34 ]. Such pronounced fluctuations make long-term exposure to parabens much more difficult to establish and require repeated sampling over time [ 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies on parabens and other endocrine disruptors polluting the environment have found that results obtained during hair analysis are similar in terms of sensitivity and repeatability to results obtained in studies on blood serum and/or urine samples [ 33 , 35 , 36 ] Simultaneously hair samples are very easy to collect, long term storage and transport even over long distances. The particular advantage of hair samples analysis is the fact that parabens and other pollutants accumulate in the hair for long time, and therefore such analysis is better to study on long-term environmental exposure than analysis of blood or urine, in which levels of pollutants are often subject to large short-term fluctuations [ 34 ]. Moreover substances levels in the hair do not change dramatically after the death of the organism, and therefore samples may also be collected from dead animals.…”

Section: Introductionmentioning

confidence: 99%

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Biomonitoring of parabens in wild boars through hair samples analysis

Gonkowski,

Tzatzarakis,

Vakonaki

et al. 2024

PLoS ONE

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Parabens are compounds widely utilized in the industry as preservative additives to personal care products, cosmetics and food. They pollute the environment and penetrate to the living organisms through the digestive tract, respiratory system and skin. Till now the knowledge about exposure of terrestrial wild mammals to parabens is extremely scarce. Therefore, this study for the first time assessed the concentration levels of five parabens commonly used in industry (methylparaben—MeP, ethylparaben—EtP propylparaben–PrP, benzylparaben -BeP and butylparaben–BuP). Substances have been analyzed in hair samples collected from wild boars using liquid chromatography-mass spectrometry (LC-MS) method. The hair is a matrix, which allows to study long-term exposure of organisms to parabens. During this study MeP was noted in 96.3% of samples with mean 88.3±72.9 pg/mg, PrP in 87.0% of samples with mean 8.5±3.3 pg/mg, BeP in 44.4% of samples with mean 17.2±12.3 pg/mg and EtP in 11.1% of samples with mean 17.2±4.8 pg/mg. In turn BuP was noted only in 3.7% of samples with concentration levels below limit of quantification (2.6 pg/mg). Statistically significant intragender differences in parabens levels have not been noted. Only BeP concentration levels depended on industrialization and density of human population of area, where the animals lived. This study indicates that wild boars are exposed to parabens, especially to MeP and PrP, and analysis of the hair seems to be a useful tool of biomonitoring of parabens in wild mammals.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biomonitoring of parabens in wild boars through hair samples analysis

Gonkowski,

Tzatzarakis,

Vakonaki

et al. 2024

PLoS ONE

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“…These chemicals are used as broad-spectrum antimicrobial preservatives in lotions/creams, skin foundation, eye makeup products, deodorants/perfumes, hair care products, shaving products, toothpastes, shampoos/conditioners, pharmaceuticals, textiles, clothes, and processed foods [ 173 , 174 ]. Parabens are absorbed by the dermal route or ingested and are systematically distributed and metabolized, being detected in human normal and tumoral tissues [ 175 ], hair [ 176 ], blood [ 171 ], saliva [ 177 ], breast milk [ 178 , 179 ], placenta [ 180 ], and urine [ 181 ]. Parabens can be found intact in the human breast [ 175 ] and preferentially accumulate in metastatic breast tumors compared to benign breast tumors [ 174 ].…”

Section: Exposure To Endocrine-disrupting Chemicals (Edcs)mentioning

confidence: 99%

Breast Cancer Exposomics

Neagu,

Jayaweera,

Corrice

et al. 2024

Life

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We are exposed to a mixture of environmental man-made and natural xenobiotics. We experience a wide spectrum of environmental exposure in our lifetime, including the effects of xenobiotics on gametogenesis and gametes that undergo fertilization as the starting point of individual development and, moreover, in utero exposure, which can itself cause the first somatic or germline mutation necessary for breast cancer (BC) initiation. Most xenobiotics are metabolized or/and bioaccumulate and biomagnify in our tissues and cells, including breast tissues, so the xenobiotic metabolism plays an important role in BC initiation and progression. Many considerations necessitate a more valuable explanation regarding the molecular mechanisms of action of xenobiotics which act as genotoxic and epigenetic carcinogens. Thus, exposomics and the exposome concept are based on the diversity and range of exposures to physical factors, synthetic chemicals, dietary components, and psychosocial stressors, as well as their associated biologic processes and molecular pathways. Existing evidence for BC risk (BCR) suggests that food-borne chemical carcinogens, air pollution, ionizing radiation, and socioeconomic status are closely related to breast carcinogenesis. The aim of this review was to depict the dynamics and kinetics of several xenobiotics involved in BC development, emphasizing the role of new omics fields related to BC exposomics, such as environmental toxicogenomics, epigenomics and interactomics, metagenomics, nutrigenomics, nutriproteomics, and nutrimiRomics. We are mainly focused on food and nutrition, as well as endocrine-disrupting chemicals (EDCs), involved in BC development. Overall, cell and tissue accumulation and xenobiotic metabolism or biotransformation can lead to modifications in breast tissue composition and breast cell morphology, DNA damage and genomic instability, epimutations, RNA-mediated and extracellular vesicle effects, aberrant blood methylation, stimulation of epithelial–mesenchymal transition (EMT), disruption of cell–cell junctions, reorganization of the actin cytoskeleton, metabolic reprogramming, and overexpression of mesenchymal genes. Moreover, the metabolism of xenobiotics into BC cells impacts almost all known carcinogenic pathways. Conversely, in our food, there are many bioactive compounds with anti-cancer potential, exerting pro-apoptotic roles, inhibiting cell cycle progression and proliferation, migration, invasion, DNA damage, and cell stress conditions. We can conclude that exposomics has a high potential to demonstrate how environmental exposure to xenobiotics acts as a double-edged sword, promoting or suppressing tumorigenesis in BC.

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“…Bisphenols, ClxBPA, and parabens were quantified using a fully validated method based on high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). 18 LOQs were set at 0.25, 0.05, and 0.00625 ng/g for BPA and parabens, bisphenol F (BPF) and bisphenol S (BPS), and ClxBPA, respectively. In both cases (urine and hair samples), LOQ was defined as the lowest level of calibration standard with acceptable accuracy and precision.…”

Section: Sample Collection and Analysismentioning

confidence: 99%

Assessment of Endocrine Disruptor Exposure in Hospital Professionals Using Hair and Urine Analyses: An Awareness Campaign

Robin,

Albouy,

Jourdain

et al. 2023

Therapeutic Drug Monitoring

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Background: In 2021, French public authorities initiated the fourth National Environmental Health Plan to prevent environment-related health risks. This plan primarily focuses on the sensitization of health professionals and health care institutions. Endocrine disruptors (EDs) are environmental factors associated with several adverse health effects, such as reproductive disorders, obesity, and cancer. This study aimed to conduct an awareness campaign among professionals at a general hospital center on the risks related to EDs. Methods: Hospital professionals were directly involved in this study, and urine and hair samples were collected to determine bisphenol and paraben exposure levels. Analyses were performed using validated liquid chromatography-tandem mass spectrometry methods, enabling the simultaneous determination of bisphenols and parabens. A questionnaire on lifestyle habits was distributed to assess its relationship with the exposure profiles. Nineteen professionals were recruited for the study. Results: Bisphenol A was detected in 95% of the urine samples, and the chlorinated derivatives of bisphenol A were between 16% and 63%. parabens showed detection frequencies between 37% and 100%, and methylparaben was quantified at an average concentration of 0.45 ± 0.46 ng/mL. In hair samples, bisphenols A, F, and S were detected at 95%–100%, chlorinated derivatives of bisphenol A were detected at 37%–68%, and parabens were detected at 100%. Conclusions: This awareness campaign may encourage health care institutions to adopt a policy of reducing endocrine disruptor exposure among their patients and professionals, who could be educated regarding the risks associated with EDs. Conducting a multicenter study to refine the results herein and establish a dynamic to prevent endocrine disruptor and environmental risks in health care systems would be valuable.

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Analytical method for the biomonitoring of bisphenols and parabens by liquid chromatography coupled to tandem mass spectrometry in human hair

Cited by 15 publications

References 39 publications

Biomonitoring of parabens in wild boars through hair samples analysis

Biomonitoring of parabens in wild boars through hair samples analysis

Breast Cancer Exposomics

Assessment of Endocrine Disruptor Exposure in Hospital Professionals Using Hair and Urine Analyses: An Awareness Campaign

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