Analytical Methods for Determination of Certain Antihypertensive Drugs

Abstract

Hypertension is a key risk factor for cardiovascular diseases. Currently, around a third of people with hypertension are undiagnosed, and of those diagnosed, around half are not taking antihypertensive medications. The World Health Organization (WHO) estimates that high blood pressure directly or indirectly causes deaths of at least nine million people globally every year. In this literature review, we will introduce all reported methods that have been developed for determination of certain antihypertensive drugs such as irbesartan, losartan, candesartan, atenolol, bisoprolol and hydrochlorothiazide in their pure form, combined form with other drugs, combined form with degradation products, and in biological samples. We also will shed the light on the most important combination of drugs that are used for treatment of hypertension.