Analytical methods for human biomonitoring of pesticides. A review

Yusà, Vicent; Millet, Maurice; Coscollà, Clara; Roca, Marta

doi:10.1016/j.aca.2015.05.032

Cited by 98 publications

(33 citation statements)

References 80 publications

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“…Biomonitoring is a way to observe the level of pesticide exposure in human populations and is an important part of evaluating existing pesticide regulations and restrictions [13][14][15]. Currently used pesticides generally have short biological half-lives and are rapidly excreted in urine.…”

Section: Introductionmentioning

confidence: 99%

Concentrations and temporal trends in pesticide biomarkers in urine of Swedish adolescents, 2000–2017

Norén

Lindh

Rylander

et al. 2020

J Expo Sci Environ Epidemiol

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Agricultural pesticides are extensively used for weed-and pest control, resulting in residues of these compounds in food. The general population is mainly exposed through dietary intake. Exposure to certain pesticides has been associated with adverse human health outcomes. Our aim was to assess urinary concentrations and temporal trends in the biomarkers of commonly used pesticides. Samples were collected from adolescents (n = 1060) in Scania, Sweden, from 2000 to 2017. Concentrations of 14 pesticide biomarkers were analyzed in urine using LC-MS/MS. Temporal trends in biomarker concentrations (ln-transformed) were evaluated using linear regression. Biomarkers of pyrethroids (3-PBA and DCCA), chlorpyrifos (TCPy), chlormequat (CCC), thiabendazole (OH-TBZ), and mancozeb (ETU) were detected in >90% of the population all sampling years. The biomarkers CCC and TCPy had the highest median concentrations (>0.8 µg/L), whereas the biomarkers of cyfluthrin (4F-3-PBA) and two pyrethroids (CFCA) had the lowest median concentrations (<0.02 µg/L). Increasing temporal trends were found for the biomarkers 3-PBA (3.7%/year), TCPy (1.7%/year) and biomarkers of pyrimethanil (11.9%/year) and tebuconazole (12.2%/year). Decreasing trends were found for CCC (-5.5%/year), OH-TBZ (−5.5%/year), and ETU (−3.9%/year). Our results suggest that Swedish adolescents are commonly exposed to pesticides in low concentrations (median concentrations <3.88 µg/L).

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Section: Introductionmentioning

confidence: 99%

Concentrations and temporal trends in pesticide biomarkers in urine of Swedish adolescents, 2000–2017

Norén

Lindh

Rylander

et al. 2020

J Expo Sci Environ Epidemiol

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“…In general, legislation considers levels above 0.5 μg L − 1 in water intended to human consumption to be unsafe [1]. Even though the use of pesticides has many decades, the development of analytical methods for their determination still remains a hot topic in analytical chemistry [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of magnetic-molecularly imprinted polymers for the HPLC-UV analysis of ametryn

Khan

Hussain

Wong

et al. 2018

Reactive and Functional Polymers

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“…The improvements of existing techniques are aimed at miniaturization, automation, simplification and the use of solventfree techniques at the sample preparation stage, in order to make them consistent with 'Green Chemistry' principles [16].…”

Section: Introductionmentioning

confidence: 99%

Fast, sensitive and reliable multi-residue method for routine determination of 34 pesticides from various chemical groups in water samples by using dispersive liquid–liquid microextraction coupled with gas chromatography–mass spectrometry

Tankiewicz

Biziuk

2017

Anal Bioanal Chem

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A simple and efficient dispersive liquid-liquid microextraction technique (DLLME) was developed by using a mixture of two solvents: 40 μL of tetrachlorethylene (extraction solvent) and 1.0 mL of methanol (disperser solvent), which was rapidly injected with a syringe into 10 mL of water sample. Some important parameters affecting the extraction efficiency, such as type and volume of solvents, water sample volume, extraction time, temperature, pH adjustment and salt addition effect were investigated. Simultaneous determination of 34 commonly used pesticides was performed by using gas chromatography coupled with mass spectrometry (GC-MS). The procedure has been validated in order to obtain the highest efficiency at the lowest concentration levels of analytes to fulfill the requirements of regulations on maximum residue limits. Under the optimum conditions, the linearity range was within 0.0096-100 μg L −1 . The limits of detection (LODs) of the developed DLLME-GC-MS methodology for all investigated pesticides were in the range of 0.0032 (endrin)-0.0174 (diazinon) μg L −1 and limits of quantification (LOQs) from 0.0096 to 0.052 μg L −1 . At lower concentration of 1 μg L −1 for each pesticide, recoveries ranged between 84% (tebufenpyrad) and 108% (deltamethrin) with relative standard deviations (RSDs) (n = 7) from 1.1% (metconazole) to 11% (parathion-mehtyl). This methodology was successfully applied to check contamination of environmental samples. The procedure has proved to be selective, sensitive and precise for the simultaneous determination of various pesticides. The optimized analytical method is very simple and rapid (less than 5 min).

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Analytical methods for human biomonitoring of pesticides. A review

Cited by 98 publications

References 80 publications

Concentrations and temporal trends in pesticide biomarkers in urine of Swedish adolescents, 2000–2017

Concentrations and temporal trends in pesticide biomarkers in urine of Swedish adolescents, 2000–2017

Synthesis and characterization of magnetic-molecularly imprinted polymers for the HPLC-UV analysis of ametryn

Fast, sensitive and reliable multi-residue method for routine determination of 34 pesticides from various chemical groups in water samples by using dispersive liquid–liquid microextraction coupled with gas chromatography–mass spectrometry

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