Analytical performance, agreement and user-friendliness of five C-reactive protein point-of-care tests

Minnaard, Margaretha C.; Pol, Alma C van de; Broekhuizen, Berna D L; Verheij, Theo; Hopstaken, Rogier; Delft, Sanne van; Kooijman-Buiting, Antoinette M J; Groot, Joris A H de; Wit, Niek J. de

doi:10.3109/00365513.2013.841985

Cited by 43 publications

(30 citation statements)

References 23 publications

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“…However, we did not manually correct for Ht, as this is in general not possible in POC situations. Several POC CRP analyzers have already been evaluated by others [4][5][6][7][8][9][10] but all except one [10] in a one to one comparison with a central laboratory method. The correlation coefficients are in general N0.95 comparable with our findings.…”

Section: Evaluation Of the Quantitative Crp Analyzersmentioning

confidence: 99%

“…In one method the measurement of the white blood cell count is combined with that of CRP [9]. In all those studies except one [10] just one method or apparatus has been evaluated and compared with an automated routine method. In this study we investigated the various commercially available methods on their applicability for general practice.…”

Section: Introductionmentioning

confidence: 99%

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Validation and evaluation of eight commercially available point of care CRP methods

Brouwer

Pelt

2015

Clinica Chimica Acta

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Section: Evaluation Of the Quantitative Crp Analyzersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Validation and evaluation of eight commercially available point of care CRP methods

Brouwer

Pelt

2015

Clinica Chimica Acta

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“…For example, when compared to the Beckman Coulter analyser, the i-CHROMA™ CRP method showed a good correlation (r 2 =0.84) and as a result was recommended as an attractive instrument for medical centers [12]. Minnard et al also showed in two comparative studies comparing the i-CHROMA™ method with some common CRP POCTs that the i-CHROMA™ CRP method is a good method for measuring CRP values [13,14]. One study by Brouwer et al also confirmed the i-CHROMA™ CRP method a good CRP POC test [15].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Point of Care Test (POCT), i-CHROMA™ Serum C-Reactive Protein (CRP) Assay and Microalbumin Urine (MAU) Methods

Bains¹,

Anyaeche²,

Wyatt³

et al. 2017

Ann Clin Lab Res

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Objectives: The objective of this study was to evaluate the performance of the Boditech i-CHROMA™ point-of-care testing (POCT) method for the quantification of serum CReactive Protein (CRP) and Urine Microalbumin (MAU) compared well with the traditional Abbott Architect Ci8200 laboratory method. Design and Methods:Serum samples of CRP (n=44) and urine samples for MAU estimation (n=25) were analysed at the Homerton University Hospital using the routine laboratory method (Abbott Architect Ci8200) and the Boditech i-CHROMA™ POCT method. Results:The i-CHROMA™ CRP and MAU method showed good correlation with that of the Abbott Architect Ci8200: r 2 =0.905 and r 2 =0.987 respectively. Overall, there was a slight negative bias seen with the i-CHROMA™ CRP method (bias=-8.15, bias difference=-9.05%) and a negative bias seen with the i-CHROMA™ MAU method (bias=35.84, bias difference=-27.88%). Conclusion:The Boditech i-CHROMA™ POCT method provide a reliable measurement of CRP and MAU and compared well with the traditional Abbott Architect Ci8200 laboratory method.

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“…The CRP POCT instrument that is used in this study (QuikRead go®, Orion Diagnostica Oy) has been shown to have adequate analytical accuracy and agreement with laboratory measurements [43,44]. The analyzer has a built-in self-check procedure that secures its correct use and correct results.…”

Section: Technical Features Of Crp Poctmentioning

confidence: 99%

Using point-of-care C-reactive protein to guide antibiotic prescribing for lower respiratory tract infections in elderly nursing home residents (UPCARE): study design of a cluster randomized controlled trial

Boere¹,

Buul²,

Hopstaken

et al. 2020

BMC Health Serv Res

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Background: Antibiotics are over-prescribed for lower respiratory tract infections (LRTI) in nursing home residents due to diagnostic uncertainty. Inappropriate antibiotic use is undesirable both on patient level, considering their exposure to side effects and drug interactions, and on societal level, given the development of antibiotic resistance. C-reactive protein (CRP) point-of-care testing (POCT) may be a promising diagnostic tool to reduce antibiotic prescribing for LRTI in nursing homes. The UPCARE study will evaluate whether the use of CRP POCT for suspected LRTI is (cost-) effective in reducing antibiotic prescribing in the nursing home setting. Methods/design: A cluster randomized controlled trial will be conducted in eleven nursing homes in the Netherlands, with the nursing home as the unit of randomization. Residents with suspected LRTI who reside at a psychogeriatric, somatic, or geriatric rehabilitation ward are eligible for study participation. Nursing homes in the intervention group will provide care as usual with the possibility to use CRP POCT, and the control group will provide care as usual without CRP POCT for residents with (suspected) LRTI. Data will be collected from September 2018 for approximately 1.5 year, using case report forms that are integrated in the electronic patient record system. The primary study outcome is antibiotic prescribing for suspected LRTI at index consultation (yes/no). Discussion: This is the first randomised trial to evaluate the effect of nursing home access to and training in the use of CRP POCT on antibiotic prescribing for LRTI, yielding high-level evidence and contributing to antibiotic stewardship in the nursing home setting. The relatively broad inclusion criteria and the pragmatic study design add to the applicability and generalizability of the study results.

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Analytical performance, agreement and user-friendliness of five C-reactive protein point-of-care tests

Abstract: Analytical performance, agreement, and user-friendliness of the POC CRP tests varied considerably, yet overall four devices showed adequate analytical performance and agreement.

Cited by 43 publications

References 23 publications

Validation and evaluation of eight commercially available point of care CRP methods

Validation and evaluation of eight commercially available point of care CRP methods

Evaluation of Point of Care Test (POCT), i-CHROMA™ Serum C-Reactive Protein (CRP) Assay and Microalbumin Urine (MAU) Methods

Using point-of-care C-reactive protein to guide antibiotic prescribing for lower respiratory tract infections in elderly nursing home residents (UPCARE): study design of a cluster randomized controlled trial

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