Analytical plasma source mass spectrometry in biomedical research

Abstract

The features of inductively coupled plasma - mass spectrometry (ICP-MS) that make it unique also make possible applications in biological chemistry and biomedical research that would be otherwise difficult or impossible. High sensitivity, characterized spectral interferences, rapid mass scanning, and individual isotope measurements are now combined with sophisticated sample preparation, separations, or stable isotope additions to achieve rapid semi-quantitative analysis, element speciation, and high accuracy. The semi-quantitative analysis of various materials, the separation and detection of macromolecules in blood and other tissues, and tracking of stable isotopes added either purposely or inadvertently to children are important applications of ICP-MS. Current functional limitations and obstacles and potential development areas also are examined.

Comparison of Serum Zinc Levels Measured by Inductively Coupled Plasma Mass Spectrometry in Preschool Children with Febrile and Afebrile Seizures

“…Unlike inductively coupled plasma atomic emission spectrometry, ICP-MS can be used for direct analysis of solution samples, can be used to measure most elements, and provides much lower detection limits and reliable isotopic analysis [32]. …”