Analytical quality by design for liquid chromatographic method development

Beg, Sarwar; Rahman, Mahfoozur

doi:10.1016/b978-0-12-820332-3.00010-8

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…Green analytical method energizes diminishing the utilization of harmful synthetics/reagents, utilizing energy-proficient equipment, and creating negligible waste. The new patterns in analytical strategy advancement center around the scaling down of the example readiness gadgets, the improvement of solventless or dissolvable limited extraction methods, and the use of less harmful solvents [75,76]. In the analytical method development of CBZ, the research published by Alam et al [66] is the only direct attempt.…”

Section: Green Analytical Methodsmentioning

confidence: 99%

Mechanism of Action, Synthesis, Properties and Analytical Methods of Cabozantinib

DWIVEDI¹,

KHABIYA²,

Shrivastava³

et al. 2023

Int J App Pharm

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Globally, the burden of cancer is substantial and growing. The impact of the burden of such diseases over society is unpredictable in terms of health lost and cost. Unfortunately, the estimates shown the burden may be increasing in the upcoming decades. Cabozantinib (CBZ) is a newly developed tyrosin kinase inhibitor (TKI) for Differentiated thyroid cancer (DTC), Hepatic Cellular Carcinoma (HCC), Medullary thyroid cancer (MTC) and Renal Cell Carcinoma (RCC). The objective of the presented review is to provide updated knowledge of drugs especially covering analytical methodologies. The review covered the introduction, mechanism of action, pharmacokinetics, synthesis and developed analytical methods by various researchers. The review covered one spectrophotometry and about twenty chromatography methods. The review will be helpful for the scientist working in this area and especially helpful for analytical scientists exploring new analytical methodologies for CBZ.

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Section: Green Analytical Methodsmentioning

confidence: 99%

Mechanism of Action, Synthesis, Properties and Analytical Methods of Cabozantinib

DWIVEDI¹,

KHABIYA²,

Shrivastava³

et al. 2023

Int J App Pharm

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“…0 5,9 . 0 13,18 ] icos-18-en-8-one. Cevadine is taken as internal standard support for the chromatographic elution of Gitingensine.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10][11][12] When compared to HPLC, the UPLC is faster, accurate, sensitive, and robust and the consumption of solvent is low and hence economical. 13 Therefore, the UPLC method has been considered due to its speed, selectivity, and sensitivity. 14 The main Principle of UPLC depends upon the Van-Deemter Expression that states the relation amid in flow rate and column efficiency.…”

Section: Introductionmentioning

confidence: 99%

Stability indicating novel analytical method development by RP-UPLC for the estimation of Gitingensine in bulk

Panduri¹,

Indireddy

Banoth³

2022

J Pharm Chem

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A new method was proposed using RP-UPLC for the determination of Gitingensine in bulk, which exhibits its power of stability output. Gitingensine is a natural product found in Kibatalia laurifolia belonging to Apocynaceae which is a steroid having the activities such as anti-inflammatory, anti-spasmodic and anti-cancer activity. Cevadine is used as an internal standard for chromatographic analysis. The elution was performed on BEH C18 (2.1 × 50 mm, 1.7 µm) column at 30 °C with a mobile phase distribution Acetonitrile: 0.1% orthophosphoric acid (60: 40) respectively. The flow rate was well- kept at 0.3 mL min-1. Retention times for Gitingensine and Cevadine were found to be 2.005 and 1. 395 min, respectively. The regression equation was found to be linear in the range of 12.5 – 75 µg/mL with a high correlation coefficient (0.999). Recovery of Gitingensine was obtained as 100.04%. Validation was done as claimed by ICH guidelines with respect to accuracy, sensitivity, robustness, and precision studies. From the insignificant variations in the analysis by changing the mobile phase, temperature, and flow rate, the robustness was studied. All the validation parameters were found to be within the specifications. Forced degradation studies revealed that when the influence of acid, alkali, peroxide, thermal, photolytic, and hydrolytic conditions were applied on the drug, it was stable. Hence, it can be concluded that the developed RP-UPLC method is economical, precise, and robust and can be adopted in regular Quality control analysis.

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A concise review of Dahlia spp., modern and powerful techniques for anthocyanins detection

Granados-Balbuena,

Gómez-Montaño,

Pacheco

et al. 2024

Chemistry Africa

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Analytical quality by design for liquid chromatographic method development

Cited by 3 publications

References 22 publications

Mechanism of Action, Synthesis, Properties and Analytical Methods of Cabozantinib

Mechanism of Action, Synthesis, Properties and Analytical Methods of Cabozantinib

Stability indicating novel analytical method development by RP-UPLC for the estimation of Gitingensine in bulk

A concise review of Dahlia spp., modern and powerful techniques for anthocyanins detection

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