Analytical techniques for vancomycin—A review

Electroanalytical Determination of Vancomycin at a Graphene‐modified Electrode: Comparison of Electrochemical Property between Graphene, Carbon Nanotube, and Carbon Black

“…The monitoring of serum vancomycin concentrations in patients is really necessary and is recommended to reduce the risk of toxicity (nephrotoxicity and ototoxicity) and improve the efficacy of vancomycin therapy . So, several methods have been described so far for vancomycin determination in body fluids and some reviews have been reported . These methods are mainly either based on immunoassay or based on high‐performance liquid chromatography (HPLC) .…”

Modern methods for vancomycin determination in biological fluids by methods based on high‐performance liquid chromatography – A review

“…) is a tricyclic glycopeptide antibiotic introduced in 1956 . This antibiotic is effective against many gram‐positive bacteria, including methicillin‐resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis , and Clostridium difficile . The antimicrobial effect of vancomycin is based on the inhibition of bacterial cell wall biosynthesis upon binding to d ‐alanyl‐ d ‐alanine precursors .…”

“…Approximately 10% of vancomycin is bound to proteins , and 80–90% of vancomycin is excreted by glomerular filtration in an unchanged form. Approximately 75% of the administered dose of vancomycin is excreted in urine within 24 h .…”

“…To the best of our knowledge, two reviews focused on vancomycin determination have been published in 2000 and 2007 . But in comparison with this work, the overviews and discussions of the LC and sample preparation methods for vancomycin measurement in biological samples were not so detailed and covered only the methods published until 2005.…”

The Effects of Different Mixing Speeds on the Elution and Strength of High-Dose Antibiotic-Loaded Bone Cement Created With the Hand-Mixed Technique

“…The collected samples were analyzed for vancomycin concentrations via high-performance liquid chromatography (HPLC) on a Waters module (Milford, MA, USA) with the Atlantis dC18 column, ultraviolet detection at 210 nm, and a mobile phase consisting of 0.05 M phosphate buffer solution: acetonitrile (91:9) at a flow rate of 1 ml/min. The concentration of vancomycin in each PBS sample was determined from a calibration curve [20].…”