Analytical technologies for lipid oxidation products analysis

Kinter, Michael

doi:10.1016/0378-4347(95)00189-p

Cited by 67 publications

(49 citation statements)

References 73 publications

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“…Alveolar air is a part of exhaled air, which has been in contact with blood inside alveoli. Dead space air does not enter the gas exchange region of the lung, and includes: mouth, nose, pharynx, trachea and bronchi (Teshima et al, (Kinter, 1995 Miekisch and Schubert, 2006). During sample collection dead space air is pulled into the sampling system diluting the alveolar matrix thus affecting quantitation.…”

Section: Samplingmentioning

confidence: 99%

Human exhaled air analytics: biomarkers of diseases

Buszewski

Kęsy

Ligor

et al. 2007

Biomedical Chromatography

691

531

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Over the last few years, breath analysis for the routine monitoring of metabolic disorders has attracted a considerable amount of scientific interest, especially since breath sampling is a non-invasive technique, totally painless and agreeable to patients. The investigation of human breath samples with various analytical methods has shown a correlation between the concentration patterns of volatile organic compounds (VOCs) and the occurrence of certain diseases. It has been demonstrated that modern analytical instruments allow the determination of many compounds found in human breath both in normal and anomalous concentrations. The composition of exhaled breath in patients with, for example, lung cancer, inflammatory lung disease, hepatic or renal dysfunction and diabetes contains valuable information. Furthermore, the detection and quantification of oxidative stress, and its monitoring during surgery based on composition of exhaled breath, have made considerable progress. This paper gives an overview of the analytical techniques used for sample collection, preconcentration and analysis of human breath composition. The diagnostic potential of different disease-marking substances in human breath for a selection of diseases and the clinical applications of breath analysis are discussed.

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Section: Samplingmentioning

confidence: 99%

Human exhaled air analytics: biomarkers of diseases

Buszewski

Kęsy

Ligor

et al. 2007

Biomedical Chromatography

691

531

View full text Add to dashboard Cite

show abstract

“…scribed synthetic procedures were followed to prepare Structures shown represent one of several isotopomers formed. The [2, H]HNE and HNE (16,20). Purification of HNE composition and distribution of the various isotopomers obtained are and deuterated HNE was achieved using silica gel coldescribed under Materials and Methods.…”

Section: Figmentioning

confidence: 99%

“…Chemical purities of the synthesized HNE and [2, H]HNE determined using GC/MS were flask were added sequentially 23 mg Pt(IV) oxide (Ald-greater than 97%. Proton NMR spectra of [2, H]HNE rich), 35 ml of pentane as solvent, and 1 g of the appro-showed no signal corresponding to vinylic hydrogen as priate 3-alkyn-1-ol. The flask was fitted with a ''T-joint'' was observed for HNE, indicating isotopic purity of the to allow evacuation and subsequent addition of 2 H 2 deuterated aldehyde.…”

Section: Figmentioning

confidence: 99%

“…The flask was fitted with a ''T-joint'' was observed for HNE, indicating isotopic purity of the to allow evacuation and subsequent addition of 2 H 2 deuterated aldehyde. Aqueous stock solutions of HNE (Cambridge Isotope Labs, Woburn, MA) from a lecture and [2, H]HNE were prepared and their concentrabottle. A balloon was fitted in-line to allow visual con-tions standardized by measuring the absorbance at 223 firmation of positive 2 H 2 pressure and assessment of nm and using an extinction coefficient of 13,750 the rate of Synthesis of cyclohexanone oxime.…”

Section: Figmentioning

confidence: 99%

“…Although isotopically labeled analogs are generally Recoveries of aldehydes were determined from buffer, plasma, and liver samples. For each aldehyde, considered ideal internal standards, the use of [2, H]HNE for this purpose has been subject to debate cyclohexanone oxime served as a recovery standard. Recovery samples were prepared by addition of 50 ng (15).…”

mentioning

confidence: 99%

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