Analytical tools for greenness assessment of chromatographic approaches: Application to pharmaceutical combinations of Indapamide, Perindopril and Amlodipine

Saleh, Sarah S.; Lotfy, Hayam M.; Tırıs, Gizem; Erk, Nevin; Rostom, Yasmin

doi:10.1016/j.microc.2020.105557

Cited by 34 publications

(9 citation statements)

References 29 publications

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“…The approach has a good green profile the higher the eco-scale value (greater than 85) that is obtained. Scores greater than 50 indicate competent green analysis, while scores less than 50 indicate insufficient green analysis 39,43,[45][46][47] The result of eco-scale values for the proposed technique and literature HPLC method 15 are shown in Table . 7.…”

Section: Greenness Assessmentmentioning

confidence: 99%

Simultaneous Determination of Binary Mixture of Estradiol and Progesterone Using Different Spectrophotometric Methods

2023

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Four rapid, accurate and very simple derivative spectrophotometric techniques were developed for the quantitative determination of binary mixtures of estradiol (E2) and progesterone (PRG) formulated as a capsule. Method I is the first derivative zero-crossing technique, derivative amplitudes were detected at the zero-crossing wavelength of 239.27 and 292.51 nm for the quantification of estradiol and 249.19 nm for Progesterone. Method II is ratio subtraction, progesterone was determined at λmax 240 nm after subtraction of interference exerted by estradiol. Method III is modified amplitude subtraction, which was established using derivative spectroscopy and mathematical manipulations. Method IIII is the absorbance ratio technique, absorbance of both medicines was measured at two wavelengths λ1= 260, -absorptive point and λ2=240max of progesterone. The Q equations were used to calculate the final concentrations. The calibration curve is linear from 5.0–140 and 2.0–32.0 µg/ml for estradiol and progesterone respectively. The proposed techniques' selectivity was tested using synthetic combinations created in the lab and assessed using the standard addition method. Using one-way ANOVA, the outputs of the proposed ways were compared, and the result showed no significant differences between the proposed techniques.

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Section: Greenness Assessmentmentioning

confidence: 99%

Simultaneous Determination of Binary Mixture of Estradiol and Progesterone Using Different Spectrophotometric Methods

2023

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“…1-a). Various analytical techniques have been reported for determination of AML, either alone or in combination with other drugs, including, spectrophotometric techniques (Attimarad et al 2019;Erden et al 2016;Hegazy et al 2015;Karadurmuş et al 2018;Khachornsakkul and Dungchai 2020;Mahant et al 2016;Saad et al 2016;Siridevi et al 2019), spectrofluorimetric techniques (Attala et al 2020;Dinç et al 2017;El-Kosasy et al 2015;Ibrahim et al 2015;Mabrouk et al 2018;Mohamed et al 2016;Mohammed 2015;Nasr and Shalan 2020;Sh Shalan et al 2015;Shereen Shalan and Nasr 2019), electrochemical techniques (Erden et al 2016;Wei et al 2016) and chromatographic techniques such as TLC-densitometry (Patel et al 2020a, b), LC-MS/ MS (Rezk and Badr 2020) and HPLC (Alaama et al 2015;Attimarad et al 2020;Desai et al 2019;Duraisamy and Jaganathan 2017;Ebeid et al 2015;Karadurmuş et al 2018;Mahant et al 2016;Nagamani et al 2020;Naik et al 2020;Patel et al Patel et al 2020a, b;Saleh et al 2020;Saputri et al 2018). Perindopril (PER), is an antihypertensive nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor used to treat hypertension and stable coronary artery disease with nomenclature of (2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid (Fig.…”

Section: Introductionmentioning

confidence: 99%

“…1-b). For determination of PER alone or in combination, a variety of analytical techniques have been reported including spectrophotometric techniques (El-Bagary et al 2016;Hegazy et al 2015;Karadurmuş et al 2018;Magdy et al 2018;Rahman et al 2017;Saad et al 2016;Siridevi et al 2019), spectrofluorimetric techniques (Al-Haj Sakur et al 2015Fael and Sakur 2015a, b;Sakur et al 2015) and chromatographic techniques including TLC-densitometry (Patel et al 2020a, b), LC-MS/MS (Rezk and Badr 2020) and HPLC (Duraisamy and Jaganathan 2017;Hassan et al 2020;Hemdan et al 2018;Karadurmuş et al 2018;Naik et al 2020;Patel et al 2020a, b;Saleh et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Spectrofluorimetric assay of amlodipine and perindopril in their raw materials, pharmaceutical formulations and spiked human plasma through the formation of complexes with Eosin Y

et al. 2023

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For quantitation of amlodipine (AML) and perindopril (PER) in their authentic, pharmaceutical formulations and spiked human plasma, a simple, sensitive, validated and inexpensive spectrofluorimetric method has been developed. The proposed method is developed to be based on quantitative quenching effect of two antihypertensive drugs on Eosin Y's native fluorescence which was achieved by developing binary complexes between each of the cited drugs in an acidic environment using acetate buffer (pH 4.4) with Eosin Y. Fluorescence quenching was recorded at 544 nm after excitation at 425 nm. For AML and PER, calibration curves were obtained over the range of 0.3–3.0 µg/mL and 0.2–2.0 µg/mL, respectively, with correlation coefficients of 0.9993 and 0.9995, respectively. The developed method was validated according to ICH guidelines. The proposed spectrofluorimetric method is regarded new and sensitive. As a result, the proposed method might be used to estimate the quality of the cited drugs in their pharmaceutical formulations and biological fluid.

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“…Green analytical methods are always the first choice for analysts worldwide for routine determination of drugs and drug products [1–6]. Such approaches ensure the least harm to the analysts and do not affect the environment adversely.…”

Section: Introductionmentioning

confidence: 99%

Development of a validated liquid chromatography–diode array detection method for simultaneous determination of olanzapine and fluoxetine in their combined formulation: Application to greenness assessment

Panda

Behera

Bera

et al. 2022

Separation Science Plus

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Olanzapine and fluoxetine hydrochloride are two promising drugs recommended for use in combination to treat bipolar psychotic disorders. In the present study, a green liquid chromatographic method is reported for simultaneous quantification of the said combination by employing analytical eco‐scale principles. The penalty point scoring process revealed an excellent greener nature of the current method than the reported methods. Chromatographic separation was achieved on a C‐18 column employing methanol and phosphate buffer of pH 3.5 as the mobile phase at a flow rate of 1.0 mL/min and detected at 227 nm. Both the analytes were separated with resolution > 2.0. Method validation revealed apt linearity (r2 = 0.999), accuracy (> 99%), and precision (overall % relative standard deviation < 1%) for quantification of the analytes. The limits of detection and quantitation were compliant as per study intent. Further, a systematized chemometrics approach using risk assessment and design of experiments revealed the influence of critical method variables on the method's robustness. Optimum system suitability and assay results confirmed selectivity and revealed the specific nature of the method. Overall, a robust and greener analytical method is established for the routine simultaneous quantification of the two antipsychotics in their combined tablet dosage form.

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Analytical tools for greenness assessment of chromatographic approaches: Application to pharmaceutical combinations of Indapamide, Perindopril and Amlodipine

Cited by 34 publications

References 29 publications

Simultaneous Determination of Binary Mixture of Estradiol and Progesterone Using Different Spectrophotometric Methods

Simultaneous Determination of Binary Mixture of Estradiol and Progesterone Using Different Spectrophotometric Methods

Spectrofluorimetric assay of amlodipine and perindopril in their raw materials, pharmaceutical formulations and spiked human plasma through the formation of complexes with Eosin Y

Development of a validated liquid chromatography–diode array detection method for simultaneous determination of olanzapine and fluoxetine in their combined formulation: Application to greenness assessment

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