The digital transformation of manufacturing firms, in addition to making operations more efficient, offers important opportunities both to promote the transition to a circular economy and to experiment with new techniques for designing smarter and greener products. This study integrates Industry 4.0 technologies, smart data, Life Cycle Assessment methodology, and material microstructural analysis techniques to develop and apply a circular eco-design model that has been implemented in the Italian ceramic tile manufacturing industry. The model has been initially adopted in a simulation environment to define five different scenarios of raw material supply, alternative to the current production one. The scenarios were then validated operationally at laboratory scale and in a pilot environment, demonstrating that a proper selection of raw material transport systems significantly improves the environmental performance of the ceramic product. Both the results of the laboratory tests and of the pre-industrial experiments have demonstrated the technological feasibility of the solutions identified with circular eco-design, enabling the re-engineering of the ceramic product as the fifth of the 6Rs of the circular economy.