Analyzing Ethnopharmacological Data Matrices on Traditional Uses of Medicinal Plants with the Contribution of Partial Order Techniques

Pirintsos, Stergios; Bariotakis, Michael; Laina, Danae; Lionis, Christos; Castanas, Elias; Brüggemann, Rainer

doi:10.1007/978-3-319-45421-4_18

Cited by 3 publications

(5 citation statements)

References 63 publications

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“…Ethnobotany is the study of complex relationships between cultures and their use of plants, focusing primarily on how plants are managed, used, and perceived across human societies. Ethnopharmacology, on the other hand, is defined as the interdisciplinary scientific exploration of traditionally employed indigenous drugs and biologically active agents [18,[27][28][29]. Therefore, ethnopharmacology has a broader focus on exploring biologically active agents from plants, minerals, animals, fungi, and microbes.…”

Section: Evolution Of Natural-product-derived Drug Development 21 Tra...mentioning

confidence: 99%

“…Moreover, taking into consideration that several data matrices have been published in many world areas, ranging from regional to continental scale, we attempted to demonstrate, for the first time, the implementation of partial-order techniques, processing ethnopharmacological information, with the purpose to reveal hidden inner structures and characteristics of reported raw data [41]. This methodology could potentially contribute to the conceptualization and management of ethnopharmacological knowledge [18].…”

Section: Evolution Of Natural-product-derived Drug Development 21 Tra...mentioning

confidence: 99%

“…Plants synthesize an immensely rich diversity of specialized secondary metabolites comprising an enormous number of active or complementary compounds [18,19]. This is due to several reasons, including (1) the high plant biodiversity in many areas of the world;…”

Section: Introductionmentioning

confidence: 99%

“…(2) their significant ecological role in plant physiology, which is related to the high variability of problems that the plants have to face (protection from herbivores, pathogens, stress (including UV protection), other plant-plant and plant-animal interactions, etc); (3) the fact that, for the same problem, different evolutionary solutions have appeared in divergent plant lineages, with identical or similar pharmacological action [18,20]; and (4) the fact that different parts of the plant and different extraction methods of the same plant may result in a different collection of active compounds, with sometimes opposing biological effects [21]. Therefore, the validating process of ethnopharmacological knowledge is a laborious, and usually partially successful, enterprise [11], taking into account that only 1/10,000 tested compounds may lead to a successful drug in a time frame of almost ten years [22].…”

Section: Introductionmentioning

confidence: 99%

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From Traditional Ethnopharmacology to Modern Natural Drug Discovery: A Methodology Discussion and Specific Examples

et al. 2022

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Ethnopharmacology, through the description of the beneficial effects of plants, has provided an early framework for the therapeutic use of natural compounds. Natural products, either in their native form or after crude extraction of their active ingredients, have long been used by different populations and explored as invaluable sources for drug design. The transition from traditional ethnopharmacology to drug discovery has followed a straightforward path, assisted by the evolution of isolation and characterization methods, the increase in computational power, and the development of specific chemoinformatic methods. The deriving extensive exploitation of the natural product chemical space has led to the discovery of novel compounds with pharmaceutical properties, although this was not followed by an analogous increase in novel drugs. In this work, we discuss the evolution of ideas and methods, from traditional ethnopharmacology to in silico drug discovery, applied to natural products. We point out that, in the past, the starting point was the plant itself, identified by sustained ethnopharmacological research, with the active compound deriving after extensive analysis and testing. In contrast, in recent years, the active substance has been pinpointed by computational methods (in silico docking and molecular dynamics, network pharmacology), followed by the identification of the plant(s) containing the active ingredient, identified by existing or putative ethnopharmacological information. We further stress the potential pitfalls of recent in silico methods and discuss the absolute need for in vitro and in vivo validation as an absolute requirement. Finally, we present our contribution to natural products’ drug discovery by discussing specific examples, applying the whole continuum of this rapidly evolving field. In detail, we report the isolation of novel antiviral compounds, based on natural products active against influenza and SARS-CoV-2 and novel substances active on a specific GPCR, OXER1.

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Section: Evolution Of Natural-product-derived Drug Development 21 Tra...mentioning

confidence: 99%

Section: Evolution Of Natural-product-derived Drug Development 21 Tra...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

From Traditional Ethnopharmacology to Modern Natural Drug Discovery: A Methodology Discussion and Specific Examples

et al. 2022

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“…Plants contain active or complementary compounds referred to as secondary metabolites which are useful for treatments (Pirintsos et al, 2017;Hartmann, 2007). Natural products offer immense contribution in the control of malaria acting as substantial components in antimalarial drug production.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antiplasmodial effects of black seeds, fenugreek and coriander seeds in albino mice infected with <i>Plasmodium berghei.</i>

Francis,

Eze,

Imafidor

2024

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Malaria remains a disease of public concern according to reports by the World Health Organization which recommends diverse therapeutic approach including the use of plant derived products to combat drug resistance in malaria treated individuals. This study therefore, evaluates the antiplasmodial effects of black seeds (Nigella sativa), fenugreek (Trigonella foenum-graecum) and coriander seeds (Coriandrum sativum) and their effects on packed cell volume and weight of experimental mice. Phytochemical analysis of the extract was conducted using Gas Chromatography-Mass Spectrometry analysis to establish the presence of antimalarial constituents. The plant extracts were screened for curative activities at dosages of 50mg/kg, 100mg/kg and 200mg/kg, in mice inoculated with Plasmodium berghei from donor mice. Chloroquine (6mg/kg body weight) was used as standard control drug. A 4-day curative assay was used to evaluate the antimalarial potentials of the plant extracts. Comparison between treated samples were analyzed using single factor analysis of variance at 95% confidence interval and 5% significance level (P<0.05). The results obtained from this study revealed significant suppression rate at 50mg/kg for Nigella sativa (67.0%), 200mg/kg for Trigonella foenum-graecum (68.3%), and 200mg/kg for Coriandrum sativum (66.7%). Chloroquine (6mg/kg) showed a higher inhibitory performance at 86.6% on day 7 post treatment compared to the plant extracts. The packed cell volume increased in groups treated with chloroquine compared to the extract treated group while the weight of mice increased in all extract groups significantly compared to the chloroquine treated group. The results of the study were statistically significant at P<0.05.

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The Process of Drug Development from Natural Sources

Kumar,

Krishnan,

Sabu

2024

Drugs From Nature: Targets, Assay Systems and Leads

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Analyzing Ethnopharmacological Data Matrices on Traditional Uses of Medicinal Plants with the Contribution of Partial Order Techniques

Cited by 3 publications

References 63 publications

From Traditional Ethnopharmacology to Modern Natural Drug Discovery: A Methodology Discussion and Specific Examples

From Traditional Ethnopharmacology to Modern Natural Drug Discovery: A Methodology Discussion and Specific Examples

Evaluation of antiplasmodial effects of black seeds, fenugreek and coriander seeds in albino mice infected with <i>Plasmodium berghei.</i>

The Process of Drug Development from Natural Sources

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