Analyzing noncovalent interactions between notoginseng saponins and lysozyme by deposition scanning intensity fading MALDI‐TOF mass spectrometry
Xintong Zhao,
Juan Ren,
Ze Wang
et al.
Abstract:Analysis of noncovalent interactions between natural products and proteins is important for rapid screening of active ingredients and understanding their pharmacological activities. In this work, the intensity fading MALDI‐TOF mass spectrometry (IF‐MALDI‐MS) method with improved reproducibility was implemented to investigate the binding interactions between saponins from Panax notoginseng and lysozyme. The benchmark IF‐MALDI‐MS experiment was established using N,N′,N″‐triacetylchitotriose‐lysozyme as a model s… Show more
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