Analyzing the Association between Hyperuricemia and Periodontitis: A Cross-Sectional Study Using KoGES HEXA Data

Abstract

<jats:p>Hyperuricemia arises from the buildup of excessive uric acid in the blood, and it is implicated in the development of periodontitis. The objective of this study was to investigate the association between hyperuricemia and periodontitis using a cross-sectional study design and Korean Genome and Epidemiology Study Health Examinee (KoGES HEXA) data. This prospective cohort study used epidemiological data from the KoGES from 2004 to 2016. Among 173,209 participants, 8809 with hyperuricemia and 126,465 controls (non-hyperuricemia) were selected. This study defined hyperuricemia as &gt;7.0 mg/dL of uric acid in men and &gt;6.0 mg/dL in women. This study analyzed the history of periodontitis among hyperuricemia and control participants. Participants’ age, gender, income, obesity, smoking, alcohol consumption, and nutritional intake were all examined. Chi-square tests, independent t-tests, and two-tailed analyses were used for statistical analysis. The adjusted OR (aOR) of hyperuricemia for periodontitis was 0.89 (95% confidence interval (CI) = 0.81–0.96, p = 0.005). This study demonstrated that hyperuricemia was associated with periodontitis. This finding meant that elevated uric acid levels could have a positive effect on periodontitis. However, further studies should be performed to determine the range of uric acid levels beneficial to periodontal health.</jats:p>

Dietary Acid Load Is Positively Associated with the Incidence of Hyperuricemia in Middle-Aged and Older Korean Adults: Findings from the Korean Genome and Epidemiology Study

“…Hyperuricemia was defined as a serum uric acid level of >7.0 mg/dL in men and >6.0 mg/dL in women, according to previous studies [ 30 , 31 , 32 , 33 ]. The endpoint for this analysis was the date of follow-up examination.…”

Evaluation of the Relationship between Drink Intake and Periodontitis Using KoGES Data

“…For the subgroup analyses, the effects of age and sex groups were examined and stratified based on the overall median age (≤52 years old and >52 years old). Two-tailed analyses were conducted, and P values < 0.05 were considered to indicate statistical significance [27][28][29]. The results were statistically analyzed using SPSS v. 24.0 (IBM, Armonk, NY, USA).…”

Cross-Sectional Analysis of the Association between Periodontitis and Cardiovascular Disease Using the Korean Genome and Epidemiology Study Data

“…The participants were questioned about the history of hypertension, diabetes mellitus, hyperlipidemia, cerebral stroke (hemorrhagic or ischemic), ischemic heart disease (angina or myocardial infarction), and periodontitis by trained interviewers [33]. Body mass index (BMI) was calculated as kg/m 2 using the health examination data.…”